ChemicalBook > CAS DataBase List > MG-132

MG-132

Product Name
MG-132
CAS No.
133407-82-6
Chemical Name
MG-132
Synonyms
MG-132;CS-216;Z-LL-CHO;Z-LLL-al;Z-LLL-CHO;(S)-MG132;MG-132(SSS);MG132/MG-132;MG-132, >=98%;Z-LEU-LEU-LEU-H
CBNumber
CB3298042
Molecular Formula
C26H41N3O5
Formula Weight
475.62
MOL File
133407-82-6.mol
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MG-132 Property

Melting point:
80-84℃ (DEC.)
alpha 
-61～-67°
Boiling point:
682.0±55.0 °C(Predicted)
Density 
1.073
Flash point:
366℃
storage temp. 
-20°C
solubility 
methanol: 1 mg/mL
form 
solid film
pka
11.14±0.46(Predicted)
color 
White
Water Solubility 
Soluble in ethanol, chloroform, methanol, water.
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
InChIKey
TZYWCYJVHRLUCT-VABKMULXSA-N
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25
WGK Germany 
3
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
474790
Product name
MG-132
Purity
A cell-permeable, potent, reversible proteasome inhibitor (K
Packaging
1mg
Price
$56.2
Updated
2024/03/01
Sigma-Aldrich
Product number
474787
Product name
MG-132, ≥95% by HPLC
Packaging
10mg
Price
$85.2
Updated
2024/03/01
Alfa Aesar
Product number
J63250
Product name
MG 132
Packaging
1mg
Price
$35.4
Updated
2023/06/20
Alfa Aesar
Product number
J63250
Product name
MG 132
Packaging
5mg
Price
$134
Updated
2023/06/20
Cayman Chemical
Product number
10012628
Product name
(S)-MG132
Purity
≥98%
Packaging
1mg
Price
$20
Updated
2024/03/01
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MG-132 Chemical Properties,Usage,Production

Description

MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell proliferation and induces macro-autophagy.2 Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.

Uses

A proteasome and NF-κB inhibitor.

Uses

MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.

Definition

ChEBI: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.

General Description

Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) and inhibits NF-κB activation (IC50 = 3 μM).

Biological Activity

Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

References

1) Tsubuki et al. (1996), Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine; J. Biochem.,? 119 572 2) Wu? et al. (2010), Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells; Autophagy, 6 228 3) Meriin? et al. (1998), Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis; J. Biol. Chem., 273 6373 4) Fiedler et al. (1998), Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132; Am. J. Respir. Cell Mol. Biol., 19 259

MG-132 Preparation Products And Raw materials

Raw materials

Preparation Products

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MG-132 Suppliers

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View Lastest Price from MG-132 manufacturers

Career Henan Chemical Co
Product
MG-132 133407-82-6
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
2tons
Release date
2019-12-19

133407-82-6, MG-132Related Search:

MG-115 Z-Leu-Leu-Beta-Hotyr-al ACHROMOPEPTIDASE Trypsin trysin-chymotrypsin Basic protease CALPAIN INHIBITOR I MG-132 Calpain Inhibitor I LACTACYSTIN L-Leu-Leu-Leu Z-LLL-AMC Z-LEU-LEU-LEU-FMK MG-262 CALPAIN INHIBITOR IV MG-132 in Solution 1 MG PROTEASOME INHIBITOR MG-132Z-LEU-LEU-LEU-H (ALDEHYDE) 5 MG PROTEASOME INHIBITOR MG-132Z-LEU-LEU-LEU-H (ALDEHYDE)

  • PROTEASOME INHIBITOR MG-132
  • N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-N-[(1S)-1-FORMYL-3-METHYLBUTYL]-L-LEUCINAMIDE
  • N-CBZ-LEU-LEU-LEUCINAL
  • MG-132
  • Z-LLL-CHO
  • Z-LL-CHO
  • Z-LEU-LEU-LEU-CHO
  • Z-LEU-LEU-LEU-H
  • Z-LEU-LEU-LEU-H (ALDEHYDE)
  • Z-LEU-LEU-LEU-ALDEHYDE
  • Z-LEU-LEU-ALDEHYDE
  • N-cbz-leu-leu-leu-al
  • z-leu-leu-leu-al
  • CALPAIN INHIBITOR IV
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-LEUCINAL
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL
  • BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-LEUCINAL
  • benzyloxycarbonylleucyl-leucyl-leucinealdehyde
  • (S)-MG132
  • N-carbobenzyloxy-Leu-Leu-Leu-al
  • MG-132;Z-LEU-LEU-LEU-AL
  • Z-Leu-Leu-Leu-al,MG132
  • Calpain inhibitor IV-2
  • MG 132;MG132;Z-LEU-LEU-LEU-CHO;CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL
  • L-LeucinaMide, N-[(phenylMethoxy)carbonyl]-L-leucyl-N-[(1S)-1-forMyl-3-Methylbutyl]-
  • MG132/MG-132
  • MG-132 [Z-Leu-Leu-Leu-CHO]
  • Z-LEU-LEU-LEU-AL, >=90% (HPLC)
  • Benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylami
  • InSolution? MG-132
  • MG-132, ≥95% by HPLC
  • N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
  • MG132, 98%, proteasome inhibitor
  • benzyl ((S)-4-Methyl-1-(((S)-4-Methyl-1-(((S)-4-Methyl-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)carbaMate
  • MG 132 Calpain inhibitor IV-2
  • N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide Calpain inhibitor IV-2 MG 132
  • MG-132, >=98%
  • CS-216
  • MG-132 - CAS 133407-82-6 - Calbiochem
  • MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem
  • InSolution MG-132 - CAS 133407-82-6 - Calbiochem
  • benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
  • Z-LLL-al
  • 133407-82-6 MG-132 C26H41N3O5
  • MG-132,Inhibitor,MG132,MG 132,complex,peptide,calpain,Autophagy,proteolytic,Proteasome,aldehyde,inhibit,Apoptosis,26S
  • MG-132 solution (10mM/L)
  • MG-132(SSS)
  • MG-132 (Ethanol Solution)
  • (S)-2-(Cbz-amino)-4-methyl-N-[(S)-4-methyl-1-[[(S)-4-methyl-1-oxo-2-pentyl]amino]-1-oxo-2-pentyl]pentanamide
  • MG-132 (Ethanol Solution), proteasome inhibitor
  • MG-132, proteasome inhibitor
  • MG-132, 10 mM in DMSO
  • 133407-82-6
  • C26H41N3O5
  • Cell Signaling Enzymes
  • BioChemical
  • Biochemicals and Reagents
  • Application Index