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Alverine citrate

Product Name
Alverine citrate
CAS No.
5560-59-8
Chemical Name
Alverine citrate
Synonyms
GaMatran;CalMabel;Spacolin;SpasMona;NSC 35459;Profenine;Prophelan;Proverine;AntispasMin;SpasMaverine
CBNumber
CB3303160
Molecular Formula
C26H35NO7
Formula Weight
473.57
MOL File
5560-59-8.mol
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Alverine citrate Property

Melting point:
100-102°
storage temp. 
2-8°C
solubility 
Slightly soluble in water and in methylene chloride, sparingly soluble in ethanol (96 per cent).
form 
Solid
color 
White to Off-White
InChIKey
RYHCACJBKCOBTJ-UHFFFAOYSA-N
CAS DataBase Reference
5560-59-8(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29214990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000687
Product name
Alverine citrate salt
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000687
Price
$223
Updated
2024/03/01
Sigma-Aldrich
Product number
A0424
Product name
Alverine citrate salt
Packaging
5g
Price
$215.6
Updated
2024/03/01
Cayman Chemical
Product number
26892
Product name
Alverine (citrate)
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
26892
Product name
Alverine (citrate)
Packaging
5g
Price
$63
Updated
2024/03/01
TRC
Product number
A575780
Product name
AlverineCitrate
Packaging
10g
Price
$65
Updated
2021/12/16
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Alverine citrate Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Originator

Alverine citrate,Kemikos

Uses

Used for studies of pharmacological activity including:

  • Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
  • Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
  • Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
  • Drug effects viewed from a signal transduction network perspective
  • Enhanced cytotoxic effect of proteasome inhibitor MG132
  • Mechanism of action on phasic smooth muscles

Uses

An adrenergic-β3 receptor agonist. Antispasmodic.

Uses

anticholinergic

Definition

ChEBI: The citrate salt of alverine, resulting from the reaction of equimolar amounts of alvarine and citric acid. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used in the treatment of irritable bowel syndrome.

Manufacturing Process

2 Methods of producing of alverine:
1. 3-Phenylpropylchloride reacted with ethylamine in the presence potassium hydroxide and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
2. 3-Phenylpropenal reacted with ethylamine in the presence hydrogen and Pt as catalyst and BaSO4 and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
In practice it is usually used as citrate.

Therapeutic Function

Anticholinergic, Spasmolytic

Alverine citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Alverine citrate Suppliers

Canada 1 China 142 Europe 3 France 1 Germany 2 India 6 Japan 1 Slovakia 1 Switzerland 1 United Kingdom 3 United States 27 Global 188
EDQM
Tel
--
Fax
--
Email
orders@edqm.eu
Country
France
ProdList
1913
Advantage
81
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View Lastest Price from Alverine citrate manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Alverine citrate 5560-59-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99.0~101.0%
Supply Ability
2000kg
Release date
2024-03-21
Henan Aochuang Chemical Co.,Ltd.
Product
Alverine citrate 5560-59-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Baoji Guokang Healthchem co.,ltd
Product
Alverine citrate 5560-59-8
Price
US $396.00/KG
Min. Order
1Kg/Bag
Purity
99
Supply Ability
6000kg
Release date
2021-06-04

5560-59-8, Alverine citrateRelated Search:

Ethyl acetate Sodium citrate BISMUTH POTASSIUM CITRATE Calcium citrate Citric acid monohydrate Potassium Citrate Ethanol Ethylparaben Sildenafil citrate Alverine TAMOXIFEN CITRATE(RG) D/L-AMPHETAMINE HYDROCHLORIDE 3-METHYLGLUTARIC ACID Citric acid TRICARBALLYLIC ACID (S)-(+)-CITRAMALIC ACID 2-Hydroxyisobutyric acid (R)-(-)-CITRAMALIC ACID

  • Alverine base or citrate
  • alverine dihydrogen citrate
  • Profenil citrate
  • AntispasMin
  • CalMabel
  • n-ethyl-3,3'-diphenyldipropylamine citrate
  • N-ETHYL-3,3'-DIPHENYLDIPROPYLAMINE CITRATE SALT
  • N-ETHYL-3,3-DIPHENYLDIPROPYLAMINE CITRATE SALT
  • GaMatran
  • N-Ethyl-N-(3-phenylpropyl)benzenepropanaMine 2-Hydroxy-1,2,3- propanetricarboxylate
  • NSC 35459
  • Profenine
  • Prophelan
  • Proverine
  • Spacolin
  • SpasMaverine
  • SpasMona
  • Alverine citrate iMpurity
  • Benzenepropanamine, N-ethyl-N-(3-phenylpropyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
  • N-Ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine citrate
  • Alverine Citric Acid
  • Alverine Citrate Imp. (EP)
  • BIS-GAMMA-PHENYLPROPYLETHYLAMINE DIHYDROGEN CITRATE
  • ALVERINE CITRATE
  • ALVERINE CITRATE SALT
  • Alverine Citric Acid-D5
  • Alverine citrate CRS
  • Alverine citrate ISO 9001：2015 REACH
  • Alverine Citrate (NSC 35459)
  • Alverine citrate EP9.0
  • N-Ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine 2-hydroxypropane-1,2,3-tricarboxylate
  • 5560-59-8
  • C26H35NO7
  • C20H27NC6H8O7
  • Organic Building Blocks
  • Nitrogen Compounds
  • Building Blocks
  • Amine Salts
  • Pharmaceutical intermediates
  • SPASMAVERINE
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals