ChemicalBook > CAS DataBase List > 3,5-Dibromo-2-pyridylamine

3,5-Dibromo-2-pyridylamine

Product Name
3,5-Dibromo-2-pyridylamine
CAS No.
35486-42-1
Chemical Name
3,5-Dibromo-2-pyridylamine
Synonyms
AKOS BB-8249;AURORA KA-520;ASISCHEM X26831;AKOS BBS-00001351;TIMTEC-BB SBB000910;2-Amino-3,5-dibromo;Xylulose Impurity 2;SALOR-INT L495980-1EA;LABOTEST-BB LT00000217;Palbociclib Impurity 90
CBNumber
CB3303872
Molecular Formula
C5H4Br2N2
Formula Weight
251.91
MOL File
35486-42-1.mol
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3,5-Dibromo-2-pyridylamine Property

Melting point:
104-105 °C (lit.)
Boiling point:
253.9±35.0 °C(Predicted)
Density 
2.147±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
1.89±0.49(Predicted)
Appearance
Light yellow to yellow Solid
BRN 
119390
InChI
InChI=1S/C5H4Br2N2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)
InChIKey
WJMJWMSWJSACSN-UHFFFAOYSA-N
SMILES
C1(N)=NC=C(Br)C=C1Br
CAS DataBase Reference
35486-42-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A1588
Product name
2-Amino-3,5-dibromopyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$18
Updated
2025/07/31
TCI Chemical
Product number
A1588
Product name
2-Amino-3,5-dibromopyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$28
Updated
2025/07/31
TRC
Product number
A610678
Product name
2-Amino-3,5-dibromopyridine
Packaging
2.5g
Price
$65
Updated
2021/12/16
Usbiological
Product number
415046
Product name
2-Amino-3,5-dibromopyridine
Packaging
500mg
Price
$305
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0018249
Product name
2-AMINO-3,5-DIBROMO PYRIDINE
Purity
95.00%
Packaging
5G
Price
$774.04
Updated
2021/12/16
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3,5-Dibromo-2-pyridylamine Chemical Properties,Usage,Production

Chemical Properties

yellow to brown fine crystalline powder

General Description

The synthesis of 2-amino-3,5-dibromopyridine complexes and their analysis by single crystal X-ray diffraction has been studied.

Synthesis

504-29-0

1072-97-5

35486-42-1

General procedure for the synthesis of 2-amino-5-bromopyridine and 2-amino-3,5-dibromopyridine from 2-aminopyridine: 28.2 g (0.3 mol) of 2-aminopyridine was dissolved in 50 ml of acetic acid. The solution is cooled to below 20°C by means of an ice bath and 48 g (15.4 ml, 0.3 mol) of bromine dissolved in 30 ml of acetic acid is added slowly and dropwise over a period of 1 h under vigorous stirring. The temperature was maintained below 20°C at the beginning of the reaction. Upon addition of half of the bromine solution, the reaction temperature was raised to 50°C to promote precipitation of 2-amino-5-bromopyridine hydrobromide. At 50°C, the hydrobromide typically begins to crystallize when about three-quarters of the bromine is added. After completion of the bromine addition, stirring of the reaction mixture was continued for 1 hour, followed by dilution with 75 mL of water to dissolve the hydrobromide. The reaction solution is transferred to a 500 ml beaker and neutralized by the slow addition of 120 ml of 40% sodium hydroxide solution under stirring and cooling conditions. Filtration and drying gave a crude product of 2-amino-5-bromopyridine containing a small amount of 2-amino-3,5-dibromopyridine. The 2-amino-3,5-dibromopyridine was removed from the crude product by washing with 500 ml of hot petroleum ether in three passes. The final yield of 2-amino-5-bromopyridine was 32-34.7 g (62-67% yield) with a melting point of 134°C (literature value: 132-135°C).

Purification Methods

Steam distil it and recrystallise it from aqueous EtOH or pet ether. [Beilstein 22 H 431, 22 II 333, 22 III/IV 4041.]

References

[1] Synthetic Communications, 1986, vol. 16, # 13, p. 1641 - 1646
[2] Canadian Journal of Chemistry, 2005, vol. 83, # 2, p. 146 - 149
[3] Synthesis (Germany), 2015, vol. 47, # 20, p. 3169 - 3178
[4] Journal of Organic Chemistry, 1983, vol. 48, # 7, p. 1064 - 1069
[5] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 7, p. 2455 - 2478

3,5-Dibromo-2-pyridylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,5-Dibromo-2-pyridylamine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3,5-Dibromo-2-pyridylamine 35486-42-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-30
Hebei Chuanghai Biotechnology Co., Ltd
Product
3,5-Dibromo-2-pyridylamine 35486-42-1
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
Hebei Yanxi Chemical Co., Ltd.
Product
3,5-Dibromo-2-pyridylamine 35486-42-1
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-24

35486-42-1, 3,5-Dibromo-2-pyridylamineRelated Search:

2-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE 2-Amino-3,5-dibromo-4-methylpyridine 3,5-DIBROMO-2-NITROPYRIDINE 3,5-Dibromopyridine 2,4-DIBROMO-3-AMINOPYRIDINE 2,6-Dibromopyridin-3-amine 4-AMINO-2,6-DIBROMOPYRIDINE 3,5-Dibromo-2-pyridylamine 2-Amino-3,5-dibromo-4,6-dimethylpyridine 2,6-DIAMINE-3,5-DIBROMOPYRIDINE 4-(3,5-DIBROMO-2-PYRIDYLAZO)-1,3-PHENYLENEDIAMINE 3,5-DIBROMO-6-CHLORO-N-METHYLPYRIDIN-2-AMINE 6-AMINO-3,5-DIBROMOPYRIDINE-2-CARBOXAMIDE AURORA KA-375 3,5-DIBROMO-2-HYDRAZINO-4-METHYLPYRIDINE 6-AMINO-3,5-DIBROMOPYRIDINE-2-CARBONITRILE 1-(3,5-dibromopyridin-2-yl)-1-methylhydrazine 3,5-DIBROMO-N-(PHENYLMETHYL)-2-PYRIDINAMINE

  • 2-Amino-3,5-dibromo pyridine ,99%
  • 3,5-Dibromo-2-pyridinamine
  • 2-amino-3,5-dibormopyridine
  • 2-Amino-3,5-dibromopyridine,97%
  • 3,5-Dibromo-2-aminopyridine
  • 2-Amino-3,5-dibromopyridine&nbsp
  • 2-Amino-3,5-dibromo pyrdine
  • TIMTEC-BB SBB000910
  • SALOR-INT L495980-1EA
  • ASISCHEM X26831
  • AURORA KA-520
  • LABOTEST-BB LT00000217
  • 2-Amino-3,5-dibromopyridine 97%
  • 3,5-DIBROMOPYRIDIN-2-AMINE
  • AKOS BBS-00001351
  • AKOS BB-8249
  • 2-AMINO-3,5-DIBROMOPYRIDINE
  • 2-PYRIDINAMINE, 3,5-DIBROMO-
  • 2-amino-3,5-dibromopyridinehydrate
  • 2-Amino-3,5-dibromo
  • 3,5-dibromo-2-pyridylamine
  • 3,5-Dibromo-pyridin-2-ylamine
  • 3,5-Dibrom-2-pyridylamin
  • 2-Amino-3,5-dibromopyridine &gt
  • 3,5-Dibromo-2-pyridylamine ISO 9001：2015 REACH
  • Palbociclib Impurity 90
  • 2-Amino 5-bromopyrdiene
  • Xylulose Impurity 2
  • 2-Amino-3,5-dibromopyridine, 98%
  • 35486-42-1
  • C5H4N2Br2
  • C5H4Br2NxH2O
  • C5H4Br2NH2O
  • AMINE
  • Halopyridines
  • Bromopyridines
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridine
  • Amino-pyridine series
  • Bromopyridines
  • Halopyridines
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • blocks
  • Bromides
  • Pyridines