LJI308

Product Name: LJI308
CAS No.: 1627709-94-7
Chemical Name: LJI308
Synonyms: LJI308;CS-2181;LJI 308;LJI308;LJI308 >=98% (HPLC);LJI-308;LJI 308;LJI308;2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol;Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-;viability,Ribosomal S6 Kinase (RSK),LJI-308,stimulation,phosphorylation,LJI308,inhibit,mutation,Inhibitor,LJI 308,breaks,double-strand,cancer,S6K
CBNumber: CB33060938
Molecular Formula: C21H18F2N2O2
Formula Weight: 368.38
MOL File: 1627709-94-7.mol

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LJI308 Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO
form: crystalline solid
color: Light yellow to yellow

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19924
Product name: LJI308
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 19924
Product name: LJI308
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 19924
Product name: LJI308
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 19924
Product name: LJI308
Purity: ≥98%
Packaging: 25mg
Price: $745
Updated: 2024/03/01

Tocris

Product number: 6754
Product name: LJI308
Purity: ≥98%(HPLC)
Packaging: 25
Price: $505
Updated: 2021/12/16

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LJI308 Chemical Properties,Usage,Production

Uses

LJI308 is a novel potent and specific RSK inhibitor, which targets the cancer stem cell population, repressing triple-negative breast cancer growth and dissemination.

Biological Activity

lji308 is a potent and selective inhibitor of rsk. the p90 ribosomal s6 kinase (rsk) comprises a family of serine/threonine kinase which is expressed in various human cancers. rsk is the cytosolic substrate for the erk (extracellular sianal-regulated kinase), involved in direct regulation of cell survival, proliferation, and cell polarity. previous studies have demonstrated that rsk pathway is important for the growth and proliferation of cancer stem cells [1,2].the ic50 values of lji308 against rsk1, 2, and 3 were about 0.004 - 0.013 mmol/l. 10 μm lji308 could bind to nearly 100% of the rsk2. lji308 bound the n-termini of rsk1, rsk3, and rsk4 to a similar extent. lji308 inhibited s6k1 with an ic50 of 0.8 mm. in both mda-mb-231 and h358 cell lines, 1 μm and 10 μm lji308 exihibited an inhibitory effect on colony formation and cell growth with a different sensitivity [1]. in htry-lt cell lines, treating with lji308 (1-10 μm) after 4 or 8 days decreased the cell viability by up to 90%; while little to no effect was observed in the non-tumorigenic htrz cells [2].lji308, the rsk inhibitor, could be used in combination with conventional chemotherapy to overcome the drug resistance and improve survival in patients with the triple-negative breast cancer (tnbc) [2].

IC 50

0.004 to 0.013 mm for rsk1, 2, and 3.

storage

Store at -20°C

References

aronchik i, appleton b a, basham s e, et al. novel potent and selective inhibitors of p90 ribosomal s6 kinase reveal the heterogeneity of rsk function in mapk-driven cancers[j]. molecular cancer research, 2014, 12(5): 803-812.davies a h, reipas k, hu k, et al. inhibition of rsk with the novel small-molecule inhibitor lji308 overcomes chemoresistance by eliminating cancer stem cells[j]. oncotarget, 2015, 6(24): 20570.

LJI308 Preparation Products And Raw materials

Raw materials

Preparation Products

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LJI308 Suppliers

China 61 United Kingdom 1 United States 12 Global 74

MedChemexpress LLC

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Aladdin Scientific

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Cayman Chemical Company

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LJI308

LJI 308;LJI308

LJI-308;LJI 308;LJI308

CS-2181

2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol

Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-

LJI308 >=98% (HPLC)

viability,Ribosomal S6 Kinase (RSK),LJI-308,stimulation,phosphorylation,LJI308,inhibit,mutation,Inhibitor,LJI 308,breaks,double-strand,cancer,S6K

1627709-94-7