Thio-PEG2-t-butyl ester
- Product Name
- Thio-PEG2-t-butyl ester
- CAS No.
- 1398044-50-2
- Chemical Name
- Thio-PEG2-t-butyl ester
- Synonyms
- HS-PEG2-COOtBu;HS-PEG2-CH2CH2COOtBu;SH-PEG2-CH2CH2COOtBu;Thio-PEG2-t-butyl ester;Thiol-PEG2-t-butly ester;Thiol-PEG2-t-butyl ester;Thiol-PEG3-t-butly ester;tert-butyl 3-[2-(2-sulfanylethoxy)ethoxy]propanoate;tert-Butyl 3-[2-(2-mercaptoethoxy)ethoxy]propanoate;Propanoic acid, 3-[2-(2-mercaptoethoxy)ethoxy]-, 1,1-dimethylethyl ester
- CBNumber
- CB33062679
- Molecular Formula
- C11H22O4S
- Formula Weight
- 250.35
- MOL File
- 1398044-50-2.mol
Thio-PEG2-t-butyl ester Property
- Boiling point:
- 330.6±27.0 °C(Predicted)
- Density
- 1.041±0.06 g/cm3(Predicted)
- pka
- 9+-.0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T351223
- Product name
- Thiol-PEG2-t-butylEster
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- BIPG1847
- Product name
- Thio-PEG2-t-butyl ester
- Packaging
- 100mg
- Price
- $428
- Updated
- 2021/12/16
- Product number
- 437802
- Product name
- HS-PEG2-CH2CH2COOtBu
- Purity
- min.95%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
Thio-PEG2-t-butyl ester Chemical Properties,Usage,Production
Uses
Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological Activity
Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Thio-PEG2-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Thio-PEG2-t-butyl ester manufacturers
- Product
- Thiol-PEG2-t-butyl ester 1398044-50-2
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-27