ChemicalBook > CAS DataBase List > Niflumic acid

Niflumic acid

Product Name: Niflumic acid
CAS No.: 4394-00-7
Chemical Name: Niflumic acid
Synonyms: ACTOL;UP-83;sc1332;Forenol;DONALGIN;NIFLURIL;Landruma;niflumic;Niflumate;Niflumicaci
CBNumber: CB3307557
Molecular Formula: C13H9F3N2O2
Formula Weight: 282.22
MOL File: 4394-00-7.mol

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Niflumic acid Property

Melting point:: 203-204 °C
Boiling point:: 378.0±42.0 °C(Predicted)
Density: 1.3935 (estimate)
storage temp.: 2-8°C
solubility: Soluble in ethanol (~50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (~50 mg/ml), DMSO (56 mg/ml at 25°C), and acetonitrile (~50 mg/ml).
pka: pKa 2.26 ± 0.08;4.44± 0.03(H2O,t =25±0.1,I=0.01(NaCl))(Approximate)
form: Solid
color: Light orange to Yellow to Green
biological source: synthetic (organic)
Water Solubility: 19mg/L(room temperature)
Sensitive: Light Sensitive
Merck: 14,6531
Stability:: Stable, but may discolour in light. Incompatible with strong oxidizing agents. Hygroscopic.
InChIKey: JZFPYUNJRRFVQU-UHFFFAOYSA-N
NIST Chemistry Reference: Niflumic acid(4394-00-7)
EPA Substance Registry System: 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]- (4394-00-7)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36-36/37/39
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: QT2999100
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29333999
Toxicity: LD50 in rats (mg/kg): 370 orally; 155 i.p. (Sorenson)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N0630
Product name: Niflumic acid
Packaging: 10g
Price: $73.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000824
Product name: Niflumic acid
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 10 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: N0630
Product name: Niflumic acid
Packaging: 25g
Price: $164
Updated: 2025/07/31

TCI Chemical

Product number: T2353
Product name: 2-(3-Trifluoromethylanilino)nicotinic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $120
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000824
Product name: Niflumic acid
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000824
Price: $153
Updated: 2024/03/01

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Niflumic acid Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Nifluril,U.P.S.A.,France,1968

Uses

analgesic, antiinflammatory

Uses

Niflumic acid is used for the exact same indications as the drugs described above. Synonyms for this drug are actol, flunir, nifluril, and others.

Uses

Anti-inflammatory. Selective cyclooxygenase-2 (COX-2) inhibitor

Definition

ChEBI: Niflumic acid is an aromatic carboxylic acid and a member of pyridines.

Manufacturing Process

Niflumic acid is prepared as follows: Nicotinic acid, m-trifluoromethylaniline, and potassium iodide are intimately mixed and heated on an oil bath at 140°C. The mixture melts to give a dark red liquid. The temperature of the oil bath is allowed to fall to 100°C and is maintained at this temperature for an hour and a half. The mixture puffs up and forms a yellow crystalline mass. After cooling to ordinary temperature, this mass is ground up in a mortar and extracted several times with small volumes of ether to remove excess mtrifluoromethylaniline. The residue is then washed twice with 10 ml of distilled water to remove m-trifluoromethylaniline hydrochloride and potassium iodide, and finally twice with 10 ml of 95% alcohol to remove colored resinous contaminants. After drying at 100°C, 2-(m-trifluoromethylanilino)nicotinic acid is obtained as pale yellow needles (from 70% ethanol) melting at 204°C (Kofler block).

Therapeutic Function

Antiinflammatory

Trade name

Actol (Mayrhofer, Austria; Upsamedica, Spain), Donalgin (Gedeon Richter, Hungary), Livornex (Genepharm, Greece), Ni- flam (Upsamedica, Italy), Nifluril (UPSA, France; Upsamedica, Belgium, Switzerland, Portugal).

Biochem/physiol Actions

Niflumic acid (NFA), a γ-aminobutyric acid type A receptor (GABAARs) antagonist is a non-steroidal anti-inflammatory drug (NSAID) and it belongs to the fenamate class. It is also a blocker of chloride ion channel and a calcium-activated chloride channel (CaCC) inhibitor. NFA possesses anti-inflammatory property and is useful in treating rheumatic disorders. It is also an inhibitor of N-methyl-D-aspartate receptor and glycine receptor. NFA also inhibits enzymes associated with the prostaglandins synthesis.

Side effects

Niflumic acid has been used effectively to treat rheumatoid arthritis, psoriatic arthritis, and hypertrophic osteoarthritis of the hip and knee. Gastric complications are the chief adverse effects of this drug.

Synthesis

Niflumic acid, 2-3-(trifluoromethyl)anilino nicotinic acid (3.2.21), is synthesized either by the reaction of 2-chloronicotinic acid with 3-trifluoromethylaniline [84¨C86], or 2-aminonicotinic acid with 1-bromo-3-trifluoromethylbenzene [87].

Niflumic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Niflumic acid manufacturers

Moxin Chemicals

Product: Niflumic acid Impurity 4394-00-7
Price: US $0.00-0.00/mg
Min. Order: 20mg
Purity: 98
Supply Ability: 10000000
Release date: 2025-02-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: Niflumic acid 4394-00-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Niflumic acid 4394-00-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

4394-00-7, Niflumic acidRelated Search:

2-Aminopyridine Quinolinic acid Ethyl 2-(Chlorosulfonyl)acetate PHENYL VALERATE 3-Trifluoromethylpyridine Nicotinic acid 4-Dimethylaminopyridine CLOFENAMIC ACID 2,5-PYRIDINEDICARBOXYLIC ACID Stearic acid Hexafluorozirconic acid 3-Aminopyridine Folic acid Ammonium hexafluorozirconate Tolfenamic acid Flufenamic acid Citric acid Ascoric Acid

ACIDUM NIFLUMICUM

2-(α,α,α-trifluoro-m-toluidino)nicotinic acid

Nicotinic acid Solution, 100ppm

Niflumic acid solution,100ppm

ACIDUMNIFLUMICUM(NIFLUMICACID)

2-[(3-Trifluoromethylphenyl)amino]nicotinic Acid Niflumic Acid

2-[3-(Trifluoromethyl)anilino]nicotinic acid, 2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid

Niflumic acid,99%

LABOTEST-BB LT00451962

DONALGIN

2-(ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINO)NICOTINIC ACID

2-(3-TRIFLUOROMETHYLANILINO)NICOTINIC ACID

2-[(3-TRIFLUOROMETHYL)PHENYL]AMINO]-3-PYRIDINECARBOXYLIC ACID

2-[(3-TRIFLUOROMETHYLPHENYL)AMINO]NICOTINIC ACID

ACTOL

TIMTEC-BB SBB001146

NIFLUMIC ACID

NIFLURIL

TOSLAB 796450

UP-83

3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-

Acide niflumique

acideniflumique

Acido niflumico

acidoniflumico

Actol, analgesic

aza-2dimethyl-2’,3’(tetrazolyl-5)-6diphenylamino

Forenol

Landruma

Nicotinic acid, 2-(alpha,alpha,alpha-trifluoro-m-toluidino)-

Niflumate

niflumic

Nifluminic acid

sc1332

Niflumic Acid:2-[(3-trifluoromethyl) phenyl] amino-3-pyridine-carboxylic acid

2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinicaci

Nifumic Acid

Acidum Nifumicum

Niflumic acid CRS

Niflumic acid USP/EP/BP

2-3-(Trifluoromethyl)(phenylamino)pyridin-3-carboxylic acid

Niflumicaci

2-(3-Trifluoromethylanilino)nicotinic Acid, ≥ 98.0%

C15522500 NiflumiCacid

Niflumic acid Impurity

Niflonic acid

Niflumic acid, 10 mM in DMSO

4394-00-7

4934-00-7

C13H9F3N2O2

C13H8F3N2O2

Selective cyclooxygenase-2 (COX-2) inhibitor.

Cell Signaling Enzymes

Application Index

Biochemicals and Reagents

BioChemical

Cyclooxygenase Inhibitors

Cyclooxygenase (COX) Enzymes