ChemicalBook > CAS DataBase List > Flufenamic acid

Flufenamic acid

Product Name
Flufenamic acid
CAS No.
530-78-9
Chemical Name
Flufenamic acid
Synonyms
FA;FFA;Flufenamic;ci440;ANT-1;Arlef;CI 440;Parlef;Parlif;Saal-F
CBNumber
CB7118092
Molecular Formula
C14H10F3NO2
Formula Weight
281.23
MOL File
530-78-9.mol
More
Less

Flufenamic acid Property

Melting point:
132-135 °C(lit.)
Boiling point:
373.9±42.0 °C(Predicted)
Density 
1.3380 (estimate)
vapor pressure 
0Pa at 25℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of flufenamic acid in these solvents is approximately 11, 39, and 59 mg/ml, respectively.
pka
pKa 3.9 (Uncertain);3.85 (Uncertain)
form 
Crystalline Powder or Chunks
color 
Off-white to gray-green
Water Solubility 
0.0265 g/L (37 ºC)
Merck 
14,4132
BRN 
1996069
LogP
5.25
CAS DataBase Reference
530-78-9(CAS DataBase Reference)
NIST Chemistry Reference
Flufenamic acid(530-78-9)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/38
Safety Statements 
26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
CB4375000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29224999
Toxicity
LD50 in mice: 715 mg/kg orally (Zoni)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F9005
Product name
Flufenamic acid
Purity
analytical standard, for drug analysis
Packaging
10g
Price
$28.5
Updated
2024/03/01
Sigma-Aldrich
Product number
F9005
Product name
Flufenamic acid
Purity
analytical standard, for drug analysis
Packaging
50g
Price
$96
Updated
2024/03/01
TCI Chemical
Product number
T2354
Product name
N-(3-Trifluoromethylphenyl)anthranilic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$49
Updated
2024/03/01
TCI Chemical
Product number
T2354
Product name
N-(3-Trifluoromethylphenyl)anthranilic Acid
Purity
>98.0%(HPLC)(T)
Packaging
500g
Price
$387
Updated
2024/03/01
Alfa Aesar
Product number
B23583
Product name
Flufenamic acid, 97%
Packaging
10g
Price
$22.79
Updated
2023/01/06
More
Less

Flufenamic acid Chemical Properties,Usage,Production

Description

Flufenamic acid (FFA), namely N-(alpha,alpha,alpha-trifluorom-tolyl) anthranilic acid (CI-440), is an aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. It is an effective drug in the treatment of special types of migraine. Its anti-inflammatory and analgesic effects were recognized in the 1960s (Winder et al., 1963) and thus FFA is included in the family of non-steroidal anti-inflammatory drugs (NSAIDs) with mefenamic, meclofenamic (MFA) and niflumic acids (NA). Anti-inflammatory actions occur mainly through reduction of prostaglandin synthesis from arachidonic acid by inhibiting the cyclo-oxygenases.

Chemical Properties

Fluomic acid is a Pale-Yellow or light yellow-green crystal or crystalline powder with bitter taste. It is almost insoluble in water and can be dissolved in 50% ethanol. It is a non-hormonal anti-inflammatory and analgesic drug. It was prepared by photolysis of the corresponding benzotriazinone.

Originator

Flufenamic acid,AroKor Holdings Inc.

Uses

Flufenamic acid is used for moderate pain and dysmenorrhea, but it should not be used for more than 1 week due to the possibility of nephrotoxicity, gastrointestinal toxicity, and anemia. It is frequently used in combination with the anticoagulant warfarin, the effect of which is strengthened when combined with flufenamic acid.

Uses

An NSAID found to be a reversible gap junction blocker

Definition

ChEBI: flufenamic acid is an aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a non-steroidal anti-inflammatory drug, a non-narcotic analgesic and an antipyretic. It is an aromatic amino acid and an organofluorine compound. It derives from a diphenylamine, an anthranilic acid and a (trifluoromethyl)benzene. It is a conjugate acid of a flufenamate.

Manufacturing Process

A mixture 31.3 g of o-chlorobenzoic acid, 32.2 g of trifluoromethyl-maminobenzene, 3 g of copper powder, 13.8 g of waterless potassium carbonate and 100 ml amyl alcohol was refluxed for 4 hours. To the cooled mixture was added 25 ml of 10 N solution NaOH and the mixture was concentrated and filtrated. Addition to the filtrate hydrochloric acid and water give a sediment of 2-((3-trifluromethyl)phenyl)aminobenzoic acid. After recrystallization from hexane 2-((3-trifluromethyl)phenyl)aminobenzoic acid have melting point 134-136°C.

brand name

Arlef (Parke-Davis, Sankyo, Japan), Ansatin (Ono, Japan), Felunamin (Hokuriko, Japan), Romafen (Biofarma, Turkey).

Therapeutic Function

Antiinflammatory, Antirheumatic

Biological Activity

Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.

Mechanism of action

In addition to COX inhibition flufenamate like other fenamates modifies several ion channel functions, e.g., inhibition of nonselective cation conductance, calcium-activated chloride channels, voltage-gated calcium channels and potassium channels and induces blocking of gap junctions. The relevance of these activities for the analgesic and anti-inflammatory potential of fenamates is unknown.

Clinical Use

Flufenamate is a nonsteroidal anti-inflammatory drug used for the treatment of mild to moderate pain of musculoskeletal, joint or soft-tissue origin. It was marketed in a variety of topical formulations alone or in combination with other ingredients.

Safety

Flufenamic acid is used at 600 – 800 mg/d to provide a beneficial therapeutic effect in chronic polyarthritis. The adverse effects most often encountered are gastrointestinal disturbances.

Synthesis

Flufenamic acid, N-(|á,|á,|á-trifluoro-m-tolyl)anthranylic acid (3.2.18), is synthesized by the reaction of 2-chlorobenzoic acid with 3-trifluoromethylaniline in the presence of potassium carbonate and copper filings [78,79].

storage

Store at RT

More
Less

Flufenamic acid Suppliers

Shaoxing Hongda Medical Technology Co.,Ltd
Tel
18072995930
Email
sales001@hongdabova.com
Country
China
ProdList
24
Advantage
58
Nanjing Bic Biotechnology Co., Ltd
Tel
15151970915
Email
bikeshengwu@bicbiotech.com
Country
China
ProdList
107
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Ascent Scientific
Tel
4401179829988
Fax
4402030 700 369
Email
customerservice@ascentscientific.co.uk
Country
United Kingdom
ProdList
279
Advantage
60
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
More
Less

View Lastest Price from Flufenamic acid manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Atorvastatin calcium 530-78-9
Price
US $16.00/KG
Min. Order
1Kg/Bag
Purity
99
Supply Ability
20tons
Release date
2022-01-05
Zhuozhou Wenxi import and Export Co., Ltd
Product
Flufenamic acid 530-78-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Flufenamic acid 530-78-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

530-78-9, Flufenamic acidRelated Search:


  • ci440
  • CN-27,554
  • CN-27544
  • Flufacid
  • Flufenaminsaeure
  • Fluore-200
  • Fluphenamic acid
  • fluphenamicacid
  • Fullsafe
  • INF 1837
  • FlufenaMic acid, 97% 10GR
  • 2-[(3-Trifluoromethylphenyl)amino]benzoic Acid 2-(3-Trifluoromethylanilino)benzoic Acid Flufenamic Acid
  • FFA, Flufenamic acid, 3-[(2-Carboxyphenyl)amino]benzotrifluoride, 2-Carboxy-3'-(trifluoromethyl)diphenylamine
  • inf1837
  • Lanceat
  • Meralen
  • N-((m-Trifluoromethyl)phenyl)-2-aminobenzoic acid
  • N-(alpha,alpha,alpha-Trifluoro-m-tolyl)anthranilate
  • n-(alpha,alpha,alpha-trifluoro-m-tolyl)-anthranilicaci
  • n-(m-trifluoromethylphenyl)-2-aminobenzoicacid
  • Nichisedan
  • NSC-82699
  • N-(3-TRIFLUOROMETHYLPHENYL)-ANTHRANILIC&
  • FLUFENAMIC ACID 97%
  • FLUFENAMIC ACID MM(CRM STANDARD)
  • Baseand/orunspecifiedsalts
  • Flufenamicacid,98%
  • Flufenamicacid,97%
  • N-[α,α,α-Trifluoro-m-tolyl] anthranilic acid
  • 3(TRIFLUOROMETHYL)DIPHENYLAMINE-2-CARBOSYLIC ACID
  • Flufenamic
  • Flufenamic acid Solution, 100ppm
  • N-(3-[Trifluoromethyl]phenyl)anthranilic acid, N-(α,α,α-Trifluoro-m-tolyl)anthranilic acid
  • 2-((3-(trifluoromethyl)phenyl)amino)-benzoicaci
  • 2-((3-Trifluromethyl)phenyl)aminobenzoic acid
  • Achless
  • Acido flufenamico
  • acidoflufenamico
  • Ansatin
  • ANT-1
  • Anthranilic acid, N-(alpha,alpha,alpha-trifluoro-m-tolyl)-
  • Flufenamic acid, 97%, an anti-inflammatory agent
  • Flufenamic acid (FFA)
  • Etofenamate EP Impurity A
  • Arlef
  • Benzoic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-
  • C.I. 440
  • CI 440
  • TIMTEC-BB SBB001140
  • N-(A,A,A-TRIFLUORO-M-TOLYL)ANTHRANILIC ACID
  • N-(ALPHA,ALPHA,ALPHA-TRIFLUOROMETHYL-M-TOLYL)ANTHRANILIC ACID
  • N-(ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLYL)ANTHRANILIC ACID
  • N-(3-TRIFLUOROMETHYLPHENYL)ANTHRANILIC ACID
  • Paraflu
  • Parlef
  • Parlif
  • Plostene
  • Reumajust A