2-(Trifluoromethyl)phenothiazine
- Product Name
- 2-(Trifluoromethyl)phenothiazine
- CAS No.
- 92-30-8
- Chemical Name
- 2-(Trifluoromethyl)phenothiazine
- Synonyms
- 2 - Trifluoro Phenothiazine;TIMTEC-BB SBB003058;Trifluoromethylphenothiazine;2-Trifluomethylphenothiazine;2-TRIFLUORO-10H-PHENOTHIAZINE;2-Triflouromethylphenothiazine;2-(TRIFLOUOMETHYL) PHENOTHIAZINE;2-Trilfluoromethyl Phenothiazine;2-(trifluoromethyl)-phenothiazin;2-(TRIFLUOROMETHYL)PHENOTHIAZINE
- CBNumber
- CB4383095
- Molecular Formula
- C13H8F3NS
- Formula Weight
- 267.27
- MOL File
- 92-30-8.mol
2-(Trifluoromethyl)phenothiazine Property
- Melting point:
- 188-190 °C(lit.)
- Boiling point:
- 361.1±42.0 °C(Predicted)
- Density
- 1.3491 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- -2.60±0.20(Predicted)
- form
- Solid
- color
- Pale Yellow to Light Green
- BRN
- 226580
- InChI
- InChI=1S/C13H8F3NS/c14-13(15,16)8-5-6-12-10(7-8)17-9-3-1-2-4-11(9)18-12/h1-7,17H
- InChIKey
- RKGYJVASTMCSHZ-UHFFFAOYSA-N
- SMILES
- C1=C2C(SC3=C(N2)C=CC=C3)=CC=C1C(F)(F)F
- CAS DataBase Reference
- 92-30-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 10H-phenothiazine, 2-(trifluoromethyl)-(92-30-8)
- EPA Substance Registry System
- 10H-Phenothiazine, 2-(trifluoromethyl)- (92-30-8)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-22
- Safety Statements
- 36-37/39-26
- WGK Germany
- 3
- RTECS
- SP5620000
- Hazard Note
- Irritant
- TSCA
- T
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T1407
- Product name
- 2-(Trifluoromethyl)phenothiazine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $132
- Updated
- 2025/07/31
- Product number
- T791370
- Product name
- 2-(Trifluoromethyl)phenothiazine
- Packaging
- 5g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- T791370
- Product name
- 2-(Trifluoromethyl)phenothiazine
- Packaging
- 25g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 7H70-3-02
- Product name
- 2-Trifluoromethyl-10H-phenothiazine
- Purity
- 97%
- Packaging
- 5G
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 006026
- Product name
- 2-Trifluoromethyl-10H-phenothiazine
- Purity
- 97%
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
2-(Trifluoromethyl)phenothiazine Chemical Properties,Usage,Production
Chemical Properties
YELLOW TO GREEN POWDER
Uses
2-(Trifluoromethyl)phenothiazine is used in the synthesis of antitubercolosis pharmaceuticals as well as antiproliferatives.
Definition
ChEBI: 2-(trifluoromethyl)-10H-phenothiazine is a member of phenothiazines.
Synthesis
672-57-1
1204-55-3
92-30-8
GENERAL STEPS: To an oven-dried 25 mL milled-neck test tube fitted with a stirrer, S-(2-acetamidophenyl) thioacetate (0.5 mmol), 3-iodo-4-chlorobenzotrifluoride (0.6 mmol), Cs2CO3 (2.0 mmol), and DMF (3 mL) were added sequentially. The test tube was sealed with a rubber septum, evacuated and replaced with argon for three cycles. The reaction mixture was stirred at 130 °C for 10 hours. Upon completion of the reaction, it was cooled to room temperature, the reaction was quenched with deionized water (20 mL) and extracted with ethyl acetate (20 mL x 3). The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography using gradient elution (eluent: petroleum ether/ethyl acetate) to afford the target compound 2-trifluoromethyl phenothiazine.
References
[1] Synthetic Communications, 2017, vol. 47, # 7, p. 710 - 715
2-(Trifluoromethyl)phenothiazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(Trifluoromethyl)phenothiazine manufacturers
- Product
- 2-(Trifluoromethyl)phenothiazine 92-30-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-08-08
- Product
- 2-(Triflouomethyl) phenothiazine 92-30-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-08