ChemicalBook > CAS DataBase List > 2-(Trifluoromethyl)phenothiazine

2-(Trifluoromethyl)phenothiazine

Product Name
2-(Trifluoromethyl)phenothiazine
CAS No.
92-30-8
Chemical Name
2-(Trifluoromethyl)phenothiazine
Synonyms
2 - Trifluoro Phenothiazine;TIMTEC-BB SBB003058;Trifluoromethylphenothiazine;2-Trifluomethylphenothiazine;2-TRIFLUORO-10H-PHENOTHIAZINE;2-Triflouromethylphenothiazine;2-(TRIFLOUOMETHYL) PHENOTHIAZINE;2-Trilfluoromethyl Phenothiazine;2-(trifluoromethyl)-phenothiazin;2-(TRIFLUOROMETHYL)PHENOTHIAZINE
CBNumber
CB4383095
Molecular Formula
C13H8F3NS
Formula Weight
267.27
MOL File
92-30-8.mol
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2-(Trifluoromethyl)phenothiazine Property

Melting point:
188-190 °C(lit.)
Boiling point:
361.1±42.0 °C(Predicted)
Density 
1.3491 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
-2.60±0.20(Predicted)
form 
Solid
color 
Pale Yellow to Light Green
BRN 
226580
InChI
InChI=1S/C13H8F3NS/c14-13(15,16)8-5-6-12-10(7-8)17-9-3-1-2-4-11(9)18-12/h1-7,17H
InChIKey
RKGYJVASTMCSHZ-UHFFFAOYSA-N
SMILES
C1=C2C(SC3=C(N2)C=CC=C3)=CC=C1C(F)(F)F
CAS DataBase Reference
92-30-8(CAS DataBase Reference)
NIST Chemistry Reference
10H-phenothiazine, 2-(trifluoromethyl)-(92-30-8)
EPA Substance Registry System
10H-Phenothiazine, 2-(trifluoromethyl)- (92-30-8)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-22
Safety Statements 
36-37/39-26
WGK Germany 
3
RTECS 
SP5620000
Hazard Note 
Irritant
TSCA 
T
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
T1407
Product name
2-(Trifluoromethyl)phenothiazine
Purity
>98.0%(GC)
Packaging
25g
Price
$132
Updated
2025/07/31
TRC
Product number
T791370
Product name
2-(Trifluoromethyl)phenothiazine
Packaging
5g
Price
$135
Updated
2021/12/16
TRC
Product number
T791370
Product name
2-(Trifluoromethyl)phenothiazine
Packaging
25g
Price
$185
Updated
2021/12/16
SynQuest Laboratories
Product number
7H70-3-02
Product name
2-Trifluoromethyl-10H-phenothiazine
Purity
97%
Packaging
5G
Price
$10
Updated
2021/12/16
Matrix Scientific
Product number
006026
Product name
2-Trifluoromethyl-10H-phenothiazine
Purity
97%
Packaging
5g
Price
$10
Updated
2021/12/16
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2-(Trifluoromethyl)phenothiazine Chemical Properties,Usage,Production

Chemical Properties

YELLOW TO GREEN POWDER

Uses

2-(Trifluoromethyl)phenothiazine is used in the synthesis of antitubercolosis pharmaceuticals as well as antiproliferatives.

Definition

ChEBI: 2-(trifluoromethyl)-10H-phenothiazine is a member of phenothiazines.

Synthesis

672-57-1

1204-55-3

92-30-8

GENERAL STEPS: To an oven-dried 25 mL milled-neck test tube fitted with a stirrer, S-(2-acetamidophenyl) thioacetate (0.5 mmol), 3-iodo-4-chlorobenzotrifluoride (0.6 mmol), Cs2CO3 (2.0 mmol), and DMF (3 mL) were added sequentially. The test tube was sealed with a rubber septum, evacuated and replaced with argon for three cycles. The reaction mixture was stirred at 130 °C for 10 hours. Upon completion of the reaction, it was cooled to room temperature, the reaction was quenched with deionized water (20 mL) and extracted with ethyl acetate (20 mL x 3). The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography using gradient elution (eluent: petroleum ether/ethyl acetate) to afford the target compound 2-trifluoromethyl phenothiazine.

References

[1] Synthetic Communications, 2017, vol. 47, # 7, p. 710 - 715

2-(Trifluoromethyl)phenothiazine Preparation Products And Raw materials

Raw materials

Antimicrobial Flufenamic acid Sulphur 3-Methyldiphenylamine

Preparation Products

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View Lastest Price from 2-(Trifluoromethyl)phenothiazine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-(Trifluoromethyl)phenothiazine 92-30-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000KG
Release date
2024-08-08
Career Henan Chemical Co
Product
2-(Triflouomethyl) phenothiazine 92-30-8
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-08

92-30-8, 2-(Trifluoromethyl)phenothiazineRelated Search:

(Trifluoromethyl)trimethylsilane Phenothiazine 3-Trifluoromethylphenol Trifluoromethanesulfonic acid Trifluoromethanesulfonic anhydride 4-Bromobenzotrifluoride 4-(Trifluoromethyl)benzaldehyde 3-（trifluoromethyl) Cinnamaldehyde 3-(Trifluoromethyl)benzaldehyde FLUPHENAZINE HYDROCHLORIDE 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)phenothiazine Oxaflumazine 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine Fluphenazine decanoate Ciclofenazine Flutiazin 10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-2-TRIFLUOROMETHYL-PHENOTHIAZINE DIHYDROCHLORIDE triflupromazine

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  • (2R,5R)-2,5-bis(2,4,5-trimethoxyphenyl)oxolane
  • 2-Trifluomethylphenothiazine
  • 92-30-8
  • C13H8F3SN
  • C13H8F3NS
  • Trifluoperazine Fluphenazine
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