ChemicalBook > CAS DataBase List > 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol

4-Amino-3-hydrazino-1,2,4-triazol-5-thiol

Product Name: 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol
CAS No.: 1750-12-5
Chemical Name: 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol
Synonyms: AHMT;PURPALD;PURPALD(R);4-AMINO-3-HYDRAZINO-5-MERCAPTO-1,2,4-TRIAZOLE;Nsc12519;e-3-thioL;PURPAID(R);purpald tm;AKOS B029009;Purpald(R) >=99%
CBNumber: CB3311543
Molecular Formula: C2H6N6S
Formula Weight: 146.17
MOL File: 1750-12-5.mol

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4-Amino-3-hydrazino-1,2,4-triazol-5-thiol Property

Melting point:: 228-230 °C (dec.)(lit.)
Boiling point:: 275.0±23.0 °C(Predicted)
Density: 2.31±0.1 g/cm3(Predicted)
storage temp.: 0-6°C
solubility: Soluble in Dimethyl sulfoxide. (DMSO)
pka: 8.52±0.20(Predicted)
form: powder to crystal
color: White to Almost white
BRN: 134867
Stability:: Light Sensitive
InChI: InChI=1S/C2H6N6S/c3-5-1-6-7-2(9)8(1)4/h3-4H2,(H,5,6)(H,7,9)
InChIKey: RDIMQHBOTMWMJA-UHFFFAOYSA-N
SMILES: N1=C(NN)N(N)C(=S)N1
CAS DataBase Reference: 1750-12-5(CAS DataBase Reference)
EPA Substance Registry System: 1,2,4-Triazolidin-3-one, 4-amino-5-thioxo-, hydrazone (1750-12-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: 1325
WGK Germany: 3
TSCA: Yes
HazardClass: 4.1
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A0956
Product name: 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole [for Determination of Aldehydes]
Purity: >95.0%(T)
Packaging: 5g
Price: $76
Updated: 2025/07/31

TCI Chemical

Product number: A0956
Product name: 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole [for Determination of Aldehydes]
Purity: >95.0%(T)
Packaging: 25g
Price: $247
Updated: 2025/07/31

TRC

Product number: A611170
Product name: 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole
Packaging: 10g
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 258514
Product name: 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole
Packaging: 5g
Price: $337
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK177571
Product name: 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole
Purity: 99%
Packaging: 5g
Price: $38
Updated: 2021/12/16

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4-Amino-3-hydrazino-1,2,4-triazol-5-thiol Chemical Properties,Usage,Production

Chemical Properties

Beige solid

Uses

A reagent for the determination of aldehydes and other reactive chemicals

Uses

4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole is a reagent used in the determination of aldehydes and other reactive chemicals.was used in purpald assay for determination of bacterial polysaccharides containing substituted or unsubstituted glycol in residues such as glycerol, ribitol, arabinitol, furanosyl galactose and sialic acid. It was used as chromogen during the determination of catalase activity in small tissue samples. It was used as reagent in determination of formaldehyde. It was used for derivatization of neutral monosaccharides during HPLC.

Uses

Purpald^? was used in purpald assay for determination of bacterial polysaccharides containing substituted or unsubstituted glycol in residues such as glycerol, ribitol, arabinitol, furanosyl galactose and sialic acid.
It was used as chromogen during the determination of catalase activity in small tissue samples.
It was used as reagent in determination of formaldehyde.
It was used for derivatization of neutral monosaccharides during HPLC.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 26, p. 355, 1989 DOI: 10.1002/jhet.5570260216

Synthesis

17356-08-0

1750-12-5

Thiourea (0.5 mol, 38 g) and 98% hydrazine hydrate (100 mL) were used as raw materials and the mixture was refluxed in a water bath for 3 hours. After completion of the reaction, the reaction mixture was cooled and diluted with 150 mL of distilled water. Subsequently, 10 mL of 2M HCl was added to neutralize to pH about 6.5 and frozen at 0 °C for 30 min. The crude product was obtained by filtration, washed with cold water and dissolved in 375 mL of 2M HCl and digested for 15 minutes. After removal of acid-insoluble impurities, the filtrate was neutralized to pH about 6.5 with NaOH and again frozen at 0°C. The solid product was gradually precipitated, filtered, washed several times with water, dried and recrystallized from water to give 4-amino-5-hydrazino-4H-[1,2,4]-triazole-3-thiol (1) as a white solid (24 g, 65% yield); melting point 244-246 °C (literature values 231-233 °C); FTIR (cm-1) 3439, 3262, 3185, 3076, 3014, 2915, 1638; 1H NMR (400 MHz, DMSO-d6) δ 12.70 (s, 1H, SH), 7.15 (s, 1H, NH), 5.28 (s, 2H, NH2), 4.15 (s, 2H, NH2-hydrazinyl); 13C NMR (100 MHz, DMSO-d6) δ 164.9, 155.1; Elemental analysis calculated values (C2H6N6S, 146): C, 16.43; H, 4.14; N, 57.49. Measured values: C, 16.48; H, 4.01; N, 57.36.

Purification Methods

Recrystallise Purpald from H2O (0.6g in 300-400mL). The benzylidene derivative has m 245-246o(dec) from i-PrOH [Hoggarth J Chem Soc 4817 1952, Dickinson & Jacobson J Chem Soc, Perkin Trans I 975 1975.[Beilstein 26 III/IV 547.]

References

[1] Synlett, 2016, vol. 27, # 11, p. 1703 - 1706
[2] Journal of the Indian Chemical Society, 1992, vol. 69, # 9, p. 577 - 578
[3] Synthetic Communications, 2017, vol. 47, # 11, p. 1102 - 1109

4-Amino-3-hydrazino-1,2,4-triazol-5-thiol Preparation Products And Raw materials

Raw materials

1-Methyl-3-piperidinemethanol Piperazine 3-Piperidinemethanol Thionyl chloride Iodomethane

Preparation Products

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View Lastest Price from 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol 1750-12-5
Price: US $32.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-15

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol 1750-12-5
Price: US $10.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-21

Career Henan Chemical Co

Product: 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol 1750-12-5
Price: US $1045.00/KG
Min. Order: 1KG
Purity: 995
Supply Ability: 20kg
Release date: 2018-07-25

1750-12-5, 4-Amino-3-hydrazino-1,2,4-triazol-5-thiolRelated Search:

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PURPAID(R)

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4-Amino-3-hydrazino-1,2,4-triazol-5-thiol USP/EP/BP

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Purpald<SUP>&reg

4-Amino-3-hydrazino-1,2,4-triazol-5-thio

4-Amino-3-biphenyl-5-mercapto-1,2,4-triazepine (AHMT)

Purpald<sup>?</sup>

1750-12-5

C2H7N6S

C2H6N6S

Triazoles