ChemicalBook > CAS DataBase List > ZD-4190

ZD-4190

Product Name: ZD-4190
CAS No.: 413599-62-9
Chemical Name: ZD-4190
Synonyms: ZD-4190;ZD-4190 ，S6543;ZD-4190;ZD 4190;ZD4190;ZD-4190, 10 mM in DMSO;7-(2-(1H-1,2,3-Triazol-1-yl)ethoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine;4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,3-triazol-1-yl)ethoxy]-;Inhibitor,inhibit,Vascular endothelial growth factor receptor,VEGFR,Epidermal growth factor receptor,EGFR,ZD 4190,ErbB-1,HER1,ZD-4190,ZD4190
CBNumber: CB33175607
Molecular Formula: C19H16BrFN6O2
Formula Weight: 459.27
MOL File: 413599-62-9.mol

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ZD-4190 Property

storage temp.: Store at -20°C
solubility: DMSO : 20.83 mg/mL (45.35 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6801
Product name: ZD-4190
Purity: 99.20%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-6801
Product name: ZD-4190
Purity: 99.20%
Packaging: 10mg
Price: $950
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573429
Product name: ZD-4190
Packaging: 100mg
Price: $1133.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573429
Product name: ZD-4190
Packaging: 250mg
Price: $1949.9
Updated: 2021/12/16

ChemScene

Product number: CS-6801
Product name: ZD-4190
Purity: 99.20%
Packaging: 50mg
Price: $2950
Updated: 2021/12/16

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ZD-4190 Chemical Properties,Usage,Production

Uses

ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer.

in vivo

ZD4190 (100 mg/kg, p.o.) effectively delays MDA-MB-435 tumor growth in mice. In ZD4190-treated tumors, 18F-FPPRGD2 uptake has decreased significantly relative to baseline by 26.74±8.12% (p<0.05) on day 1 and by 41.19±6.63% (p<0.01) on day 3, then has returned to baseline on day 7. Tumor uptake of 18F-FLT has also decreased on both day 1 and day 3 after initiation of ZD4190 treatment. However, ZD4190 does not significantly change 18F-FDG uptake in tumors, compared with the control group^[1]. ZD4190 (50?mg/kg, p.o.) prevents outgrowth of residual tumour in a muscle model of minimal residual carcinoma^[2]. ZD4190 (12.5-100 mg/kg, p.o.) produces a dose-dependent reduction in K(trans) in PC-3 prostate tumors. At 100 mg/kg, ZD4190 reduces K(trans) in PC-3 tumors by 31% following 2 doses and by 53% following 8 doses^[3].

IC 50

EGFR; VEGFR2

References

[1] Yang M, et al. PET imaging of early response to the tyrosine kinase inhibitor ZD4190. Eur J Nucl Med Mol Imaging. 2011 Jul;38(7):1237-47. doi: 10.1007/s00259-011-1742-z. Epub 2011 Mar 1. DOI:10.1007/s00259-011-1742-z
[2] Gaballah K, et al. The antiangiogenic agent ZD4190 prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues. Br J Cancer. 2009 Aug 4;101(3):418-23. doi: 10.1038/sj.bjc.6605092. Epub 2009 Jul 21. DOI:10.1038/sj.bjc.6605092
[3] Checkley D, et al. Dynamic contrast-enhanced MRI of vascular changes induced by the VEGF-signalling inhibitor ZD4190 in human tumour xenografts. Magn Reson Imaging. 2003 Jun;21(5):475-82. DOI:10.1016/s0730-725x(02)00644-6

ZD-4190 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZD-4190 Suppliers

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413599-62-9, ZD-4190Related Search:

ZD-1611 ZD-6888 3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE ICI D2138 N-(4-METHOXYBENZOYL)-L-VALYL]-N-[(1S)-3,3,3-TR IFLUOR-1-ISOPROPYL2-OXOPROPYL]-L-PROLINAMIDE ZD7288 ICI D 6888 ZD 9379

ZD-4190

ZD-4190;ZD 4190;ZD4190

4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,3-triazol-1-yl)ethoxy]-

Inhibitor,inhibit,Vascular endothelial growth factor receptor,VEGFR,Epidermal growth factor receptor,EGFR,ZD 4190,ErbB-1,HER1,ZD-4190,ZD4190

7-(2-(1H-1,2,3-Triazol-1-yl)ethoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine

ZD-4190, 10 mM in DMSO

ZD-4190 ，S6543

413599-62-9

C19H16BrFN6O2