ChemicalBook > CAS DataBase List > 3-BROMO-4-METHOXYANILINE

3-BROMO-4-METHOXYANILINE

Product Name
3-BROMO-4-METHOXYANILINE
CAS No.
19056-41-8
Chemical Name
3-BROMO-4-METHOXYANILINE
Synonyms
4-Amino-2-bromoanisole;3-Bromo-4-methoxyanilin;3-BROMO-4-METHOXYANILINE;3-Bromo-4-methoxyaniline >Benzenamine, 3-bromo-4-methoxy-;4-Amino-2-bromoanisole, 3-Bromo-p-anisidine;3-BROMO-4-METHOXYANILINE ISO 9001：2015 REACH
CBNumber
CB3324820
Molecular Formula
C7H8BrNO
Formula Weight
202.05
MOL File
19056-41-8.mol
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3-BROMO-4-METHOXYANILINE Property

Melting point:
62 °C
Boiling point:
282.2±20.0 °C(Predicted)
Density 
1.531±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
4.13±0.10(Predicted)
color 
White to Brown
InChIKey
NMUFTXMBONJQTC-UHFFFAOYSA-N
CAS DataBase Reference
19056-41-8
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Safety

Hazard Codes 
Xi,N,T+
Risk Statements 
26/27/28-33-50
Safety Statements 
28-36/37-45-61
RIDADR 
2811
HazardClass 
IRRITANT
PackingGroup 
III
HS Code 
2921420090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3320
Product name
3-Bromo-4-methoxyaniline
Purity
>96.0%(GC)(T)
Packaging
1g
Price
$127
Updated
2025/07/31
TRC
Product number
B683610
Product name
3-Bromo-4-methoxyaniline
Packaging
500mg
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
018182
Product name
3-Bromo-4-methoxyaniline
Purity
98%
Packaging
1g
Price
$10
Updated
2021/12/16
Apolloscientific
Product number
OR45122
Product name
3-Bromo-4-methoxyaniline
Purity
97%
Packaging
1g
Price
$15
Updated
2021/12/16
SynQuest Laboratories
Product number
4656-9-Y6
Product name
3-Bromo-4-methoxyaniline
Purity
97%
Packaging
1g
Price
$16
Updated
2021/12/16
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3-BROMO-4-METHOXYANILINE Chemical Properties,Usage,Production

Uses

3-Bromo-4-methoxyaniline is an intermediate used to prepare triazole analogs of combretastatin A-4 as cytotoxic agents and inhibitors of tubulin. It is also used in the synthesis of (1,2,4-oxadiazolyl)biphenylcarbonyltetrahydrospiro[furo]indolepiperidine (SB-224289) as selective 5-HT1B receptor inverse agonist.

Synthesis

5197-28-4

19056-41-8

General procedure for the synthesis of 3-bromo-4-methoxyaniline from 2-bromo-4-nitroanisole: 2-bromo-4-nitroanisole (0.1 g, 0.43 mmol) was suspended in unstabilized 57% hydriodic acid (1.3 mL), and the reaction was heated for 5 hr at 90 °C. After completion of the reaction, the reaction mixture was cooled, diluted with ethyl acetate (5 mL) and washed sequentially with saturated aqueous sodium thiosulfate and brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated. The crude product was further purified by silica gel column chromatography to afford 3-bromo-4-methoxyaniline (0.07 g, 80% yield).

References

[1] ACS Catalysis, 2015, vol. 5, # 3, p. 1526 - 1529
[2] Patent: WO2011/98776, 2011, A1. Location in patent: Page/Page column 60
[3] Patent: US2013/53372, 2013, A1. Location in patent: Paragraph 0584; 0585
[4] Patent: US2007/123515, 2007, A1. Location in patent: Page/Page column 24
[5] Justus Liebigs Annalen der Chemie, 1883, vol. 217, p. 44

3-BROMO-4-METHOXYANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMO-4-METHOXYANILINE Suppliers

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View Lastest Price from 3-BROMO-4-METHOXYANILINE manufacturers

Career Henan Chemical Co
Product
3-BROMO-4-METHOXYANILINE 19056-41-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

19056-41-8, 3-BROMO-4-METHOXYANILINERelated Search:

EOSIN B 2-Bromo-4-nitroanisole EOSIN B 2-BROMO-5-METHOXYANILINE 5-Bromo-2-methoxyaniline, HCl 2-BROMO-4-METHOXYANILINE 2-bromo-5-aminoanisole(4-bromo-3-methoxyaniline),4-BROMO-3-METHOXYANILINE, 98+%,4-Bromo-3-methoxyaniline, 97+%,4-BROMO-3-METHOXYANILINE 4-BROMO-2-METHOXYANILINE[2-AMINO-5-BROMOANISOLE] ,4-BROMO-2-METHOXYANILINE 2-Bromo-5-methoxyaniline, HCl 5-BROMO-2-METHOXYANILINE 2-Bromoanisole 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE 1,3-DIBROMO-2-METHOXY-5-NITROBENZENE 2-BROMO-1-(4-FLUOROPHENOXY)-4-NITROBENZENE 3-Bromo-4-methoxyaniline hydrochloride 2-BROMO-3-METHOXYANILINE HYDROCHLORIDE 2-BROMO-5-METHOXYANILINE SULPHATE 2-BROMO-6-METHOXYANILINE

  • 3-BROMO-4-METHOXYANILINE
  • 4-Amino-2-bromoanisole
  • 4-Amino-2-bromoanisole, 3-Bromo-p-anisidine
  • 3-Bromo-4-methoxyaniline &gt
  • Benzenamine, 3-bromo-4-methoxy-
  • 3-BROMO-4-METHOXYANILINE ISO 9001：2015 REACH
  • 3-Bromo-4-methoxyanilin
  • 19056-41-8
  • Phenyls & Phenyl-Het
  • Amines
  • Phenyls & Phenyl-Het