4-BROMO-3-METHOXYANILINE
- Product Name
- 4-BROMO-3-METHOXYANILINE
- CAS No.
- 19056-40-7
- Chemical Name
- 4-BROMO-3-METHOXYANILINE
- Synonyms
- 4-Bromo-m-anisidine;5-Amino-2-bromoanisole;-BROMO-3-METHOXYANILINE;4-BROMO-3-METHOXYANILINE;3-methoxy-4-bromoaniline;4-methoxy-3-bromo aniline;4-Bromo-3-methoxyaniline 98%;4-Bromo-3-methoxybenzenamine;4-BROMO-3-METHOXY-PHENYLAMINE;4-BROMO-3-METHOXYANILINE, 98+%
- CBNumber
- CB6465920
- Molecular Formula
- C7H8BrNO
- Formula Weight
- 202.05
- MOL File
- 19056-40-7.mol
4-BROMO-3-METHOXYANILINE Property
- Melting point:
- 96-100 °C(lit.)
- Boiling point:
- 272.1±20.0 °C(Predicted)
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 3.47±0.10(Predicted)
- form
- solid
- color
- Beige
- BRN
- 2690835
- InChI
- InChI=1S/C7H8BrNO/c1-10-7-4-5(9)2-3-6(7)8/h2-4H,9H2,1H3
- InChIKey
- RUTNWXBHRAIQSP-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(Br)C(OC)=C1
- CAS DataBase Reference
- 19056-40-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B415336
- Product name
- 4-Bromo-3-(methyloxy)aniline
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B415336
- Product name
- 4-Bromo-3-(methyloxy)aniline
- Packaging
- 25g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- B415336
- Product name
- 4-Bromo-3-(methyloxy)aniline
- Packaging
- 100g
- Price
- $440
- Updated
- 2021/12/16
- Product number
- J90933
- Product name
- 4-Bromo-3-methoxyaniline
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 4656-9-01
- Product name
- 4-Bromo-3-methoxyaniline
- Purity
- 98%
- Packaging
- 5G
- Price
- $25
- Updated
- 2021/12/16
4-BROMO-3-METHOXYANILINE Chemical Properties,Usage,Production
Chemical Properties
White to brown crystalline powder
Uses
4-Bromo-3-(methyloxy)aniline is a useful reagent for organic synthesis and other chemical processes. It is used in the preparation of 4-Anilino substituted α-carboline compounds as active Brk inhibitors (breast tumor kinase) which are interesting targets for cancer therapy.
Synthesis
77337-82-7
19056-40-7
General procedure for the synthesis of 4-bromo-3-methoxyaniline from 2-bromo-5-nitroanisole: To a solution of 1-bromo-2-methoxy-4-nitrobenzene (23 g, 99.6 mmol) in tetrahydrofuran (THF, 200 mL) was added ammonium chloride (64 g, 1.2 mol) and zinc powder (78.1 g, 1.2 mol). The reaction mixture was heated to reflux overnight. After completion of the reaction, the mixture was cooled to room temperature, filtered through a bed of diatomite (Celite) and the filtrate was concentrated under reduced pressure. The concentrated residue was partitioned between water (200 mL) and ethyl acetate (200 mL). The organic layer was separated, washed with brine solution (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 4-bromo-3-methoxyaniline (17.4 g, 87% yield) as a yellow solid. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, DMSO-d6, 400 MHz): δ 7.1 (d, 1H), 6.31 (s, 1H), 6.1 (d, 1H), 5.27 (bs, 2H), 3.72 (s, 3H) ppm.
References
[1] Patent: US4882354, 1989, A
[2] Patent: WO2015/6100, 2015, A1. Location in patent: Page/Page column 194
[3] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 10, p. 979 - 988
[4] Patent: WO2007/37187, 2007, A1. Location in patent: Page/Page column 127
[5] Tetrahedron Letters, 1995, vol. 36, # 42, p. 7583 - 7586
4-BROMO-3-METHOXYANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-3-METHOXYANILINE manufacturers
- Product
- 4-BROMO-3-METHOXYANILINE 19056-40-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 4-BROMO-3-METHOXYANILINE 19056-40-7
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04