ChemicalBook > CAS DataBase List > 4-BROMO-3-METHOXYANILINE

4-BROMO-3-METHOXYANILINE

Product Name
4-BROMO-3-METHOXYANILINE
CAS No.
19056-40-7
Chemical Name
4-BROMO-3-METHOXYANILINE
Synonyms
4-Bromo-m-anisidine;5-Amino-2-bromoanisole;-BROMO-3-METHOXYANILINE;4-BROMO-3-METHOXYANILINE;3-methoxy-4-bromoaniline;4-methoxy-3-bromo aniline;4-Bromo-3-methoxyaniline 98%;4-Bromo-3-methoxybenzenamine;4-BROMO-3-METHOXY-PHENYLAMINE;4-BROMO-3-METHOXYANILINE, 98+%
CBNumber
CB6465920
Molecular Formula
C7H8BrNO
Formula Weight
202.05
MOL File
19056-40-7.mol
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4-BROMO-3-METHOXYANILINE Property

Melting point:
96-100 °C(lit.)
Boiling point:
272.1±20.0 °C(Predicted)
Density 
1.531±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
3.47±0.10(Predicted)
form 
solid
color 
Beige
BRN 
2690835
InChI
InChI=1S/C7H8BrNO/c1-10-7-4-5(9)2-3-6(7)8/h2-4H,9H2,1H3
InChIKey
RUTNWXBHRAIQSP-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(Br)C(OC)=C1
CAS DataBase Reference
19056-40-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-43
Safety Statements 
36/37
RIDADR 
UN2811
WGK Germany 
2
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29222990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B415336
Product name
4-Bromo-3-(methyloxy)aniline
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
B415336
Product name
4-Bromo-3-(methyloxy)aniline
Packaging
25g
Price
$140
Updated
2021/12/16
TRC
Product number
B415336
Product name
4-Bromo-3-(methyloxy)aniline
Packaging
100g
Price
$440
Updated
2021/12/16
AK Scientific
Product number
J90933
Product name
4-Bromo-3-methoxyaniline
Packaging
1g
Price
$10
Updated
2021/12/16
SynQuest Laboratories
Product number
4656-9-01
Product name
4-Bromo-3-methoxyaniline
Purity
98%
Packaging
5G
Price
$25
Updated
2021/12/16
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4-BROMO-3-METHOXYANILINE Chemical Properties,Usage,Production

Chemical Properties

White to brown crystalline powder

Uses

4-Bromo-3-(methyloxy)aniline is a useful reagent for organic synthesis and other chemical processes. It is used in the preparation of 4-Anilino substituted α-carboline compounds as active Brk inhibitors (breast tumor kinase) which are interesting targets for cancer therapy.

Synthesis

77337-82-7

19056-40-7

General procedure for the synthesis of 4-bromo-3-methoxyaniline from 2-bromo-5-nitroanisole: To a solution of 1-bromo-2-methoxy-4-nitrobenzene (23 g, 99.6 mmol) in tetrahydrofuran (THF, 200 mL) was added ammonium chloride (64 g, 1.2 mol) and zinc powder (78.1 g, 1.2 mol). The reaction mixture was heated to reflux overnight. After completion of the reaction, the mixture was cooled to room temperature, filtered through a bed of diatomite (Celite) and the filtrate was concentrated under reduced pressure. The concentrated residue was partitioned between water (200 mL) and ethyl acetate (200 mL). The organic layer was separated, washed with brine solution (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 4-bromo-3-methoxyaniline (17.4 g, 87% yield) as a yellow solid. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, DMSO-d6, 400 MHz): δ 7.1 (d, 1H), 6.31 (s, 1H), 6.1 (d, 1H), 5.27 (bs, 2H), 3.72 (s, 3H) ppm.

References

[1] Patent: US4882354, 1989, A
[2] Patent: WO2015/6100, 2015, A1. Location in patent: Page/Page column 194
[3] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 10, p. 979 - 988
[4] Patent: WO2007/37187, 2007, A1. Location in patent: Page/Page column 127
[5] Tetrahedron Letters, 1995, vol. 36, # 42, p. 7583 - 7586

4-BROMO-3-METHOXYANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-3-METHOXYANILINE Suppliers

Canada 1 China 194 Germany 3 India 8 Italy 1 Switzerland 1 United Kingdom 13 United States 26 Global 247
Labotest
Tel
--
Fax
--
Email
sales@labotest.com
Country
Germany
ProdList
3564
Advantage
42
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 4-BROMO-3-METHOXYANILINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
4-BROMO-3-METHOXYANILINE 19056-40-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
4-BROMO-3-METHOXYANILINE 19056-40-7
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

19056-40-7, 4-BROMO-3-METHOXYANILINERelated Search:

2-BROMO-5-NITROANISOLE 4-BROMO-3-ETHOXYANILINE HYDROCHLORIDE 2-BROMO-5-NITROETHOXYBENZENE 4-BROMO-3-METHOXYANILINE 2-BROMO-5-METHOXYANILINE 5-Bromo-2-methoxyaniline, HCl 4-BROMO-2-METHOXYANILINE[2-AMINO-5-BROMOANISOLE] ,4-BROMO-2-METHOXYANILINE 2-BROMO-4-METHOXYANILINE 2-Bromo-5-methoxyaniline, HCl 5-BROMO-2-METHOXYANILINE 2-Bromoanisole m-Anisidine N-(2,4-DIBROMO-5-METHOXYPHENYL)CYCLOHEXYLFORMAMIDE 2-BROMO-3-METHOXYANILINE HYDROCHLORIDE 3-Bromo-4-methoxyaniline hydrochloride 3-BROMO-4-METHOXYANILINE 2-BROMO-6-METHOXYANILINE 3-Bromo-4-methoxyaniline hydrochloride

  • 4-Bromo-m-anisidine
  • 4-BROMO-3-METHOXY-PHENYLAMINE
  • 4-BROMO-3-METHOXYANILINE
  • 5-Amino-2-bromoanisole
  • 4-BROMO-3-METHOXYANILINE, 98+%
  • 4-Bromo-3-methoxyaniline 98%
  • 2-bromo-5-aminoanisole(4-bromo-3-methoxyaniline)
  • 4-Bromo-3-methoxyaniline, 97+%
  • 2-AMino-5-broMo-6-Methoxypyridine
  • 5-Amino-2-bromoanisole, 4-Bromo-m-anisidine
  • 5-AMino-2-broMoanisole[4-BroMo-3-Methoxyaniline]
  • BenzenaMine,4-broMo-3-Methoxy-
  • 4-BROMO-3-METHOXYANILINE ISO 9001：2015 REACH
  • 3-methoxy-4-bromoaniline
  • 4-methoxy-3-bromo aniline
  • 4-Bromo-3-methoxybenzenamine
  • -BROMO-3-METHOXYANILINE
  • 19056-40-7
  • 9056-40-7
  • BrC6H3OCH3NH2
  • C7
  • Amines
  • Building Blocks
  • Organic Building Blocks
  • Nitrogen Compounds
  • amine| alkyl bromide
  • Amines
  • C7
  • Nitrogen Compounds
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Bromine Compounds
  • Anilines, Aromatic Amines and Nitro Compounds
  • Benzene series
  • Anilines, Amides & Amines