ChemicalBook > CAS DataBase List > 2,4-Dihydroxypyrimidine-5-carboxylic acid

2,4-Dihydroxypyrimidine-5-carboxylic acid

Product Name: 2,4-Dihydroxypyrimidine-5-carboxylic acid
CAS No.: 23945-44-0
Chemical Name: 2,4-Dihydroxypyrimidine-5-carboxylic acid
Synonyms: Uracil 5-carboxylate;5-Pyrimidinecarboxylic;URACIL-5-CARBOXYLIC ACID;NSC 79561;ISO-OROTIC ACID;5-carboxyuracil;Uracil Impurity 1;RARECHEM AL BO 2377;Uracil-5-Carboxylic;uracil-5-carboxylicaci
CBNumber: CB3327326
Molecular Formula: C5H4N2O4
Formula Weight: 156.1
MOL File: 23945-44-0.mol

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2,4-Dihydroxypyrimidine-5-carboxylic acid Property

Melting point:: 283 °C (dec.)(lit.)
Boiling point:: 280.29°C (rough estimate)
Density: 1.6814 (rough estimate)
refractive index: 1.4800 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO
form: Crystalline Powder
pka: 5.08±0.20(Predicted)
color: White to slightly yellow
Water Solubility: 1.8g/L(20 ºC)
InChI: InChI=1S/C5H4N2O4/c8-3-2(4(9)10)1-6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
InChIKey: ZXYAAVBXHKCJJB-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(C(O)=O)C(=O)N1
CAS DataBase Reference: 23945-44-0(CAS DataBase Reference)
EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo- (23945-44-0)

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Safety

Risk Statements: 36/37/38
Safety Statements: 24/25
WGK Germany: 3
TSCA: Yes
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 126268
Product name: 2,4-Dihydroxypyrimidine-5-carboxylic acid
Purity: 95%
Packaging: 5g
Price: $59.9
Updated: 2025/07/31

TCI Chemical

Product number: I1020
Product name: 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid
Packaging: 5G
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: I1020
Product name: 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid
Packaging: 25G
Price: $113
Updated: 2025/07/31

TRC

Product number: D494868
Product name: 2,4-Dihydroxypyrimidine-5-carboxylic acid
Packaging: 1g
Price: $40
Updated: 2021/12/16

Apolloscientific

Product number: OR6297
Product name: 2,4-Dihydroxypyrimidine-5-carboxylic acid
Packaging: 1g
Price: $44
Updated: 2021/12/16

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2,4-Dihydroxypyrimidine-5-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellow crystalline powder or

Uses

2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) has been used for the visual sensing of melamine (at parts-per-billion (ppb) level) by a highly sensitive analytical method based on Au nanoparticles.

Definition

ChEBI: Uracil-5-carboxylic acid is a pyrimidinemonocarboxylic acid that is uracil carrying a carboxy group at position 5. It is functionally related to a uracil. It is a conjugate acid of a uracil-5-carboxylate. It is a tautomer of a 2,4-dihydroxypyrimidine-5-carboxylic acid.

General Description

2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) has been obtained from 5-formyluracil by the action of enzyme, thymine 7-hydroxylase. It has been used to synthesize N1-alkylated uracil derivatives.

Synthesis

65-71-4

23945-44-0

The general procedure for synthesizing uracil-5-carboxylic acid from 5-methyluracil was as follows: 100 g of 5-methyluracil and 300 mL of deionized water were added to an autoclave reactor, followed by the addition of 35 mL of a 30% hydrogen peroxide solution. Next, 15 g of 1-hydroxy-1,2,3-benzotriazin-4(3H)-one and 35 g of a pre-prepared catalyst (as described in Example 3) were added. The atmosphere in the autoclave was replaced with oxygen and the reaction system was subsequently heated to 130°C and maintained at this temperature for 3 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and filtered to remove insoluble material. The filtrate was concentrated under reduced pressure and poured into an ice-water mixture for cooling and crystallization, resulting in 150 g of white solid product. The yield of this step was 96.1%, and the purity of the product was 99.3% as analyzed by high performance liquid chromatography (HPLC).

References

[1] Patent: CN108341785, 2018, A. Location in patent: Paragraph 0014-0020
[2] Nucleic Acids Research, 2015, vol. 43, # 20, p. 10026 - 10038
[3] Nucleic Acids Research, 2015, vol. 43, # 20, p. 10026 - 10038

2,4-Dihydroxypyrimidine-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Ethanol Triethyl orthoformate Sodium Urea Sodium hydroxide Diethyl malonate

Preparation Products

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View Lastest Price from 2,4-Dihydroxypyrimidine-5-carboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2,4-Dihydroxypyrimidine-5-carboxylic acid 23945-44-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,4-Dihydroxypyrimidine-5-carboxylic acid 23945-44-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,4-Dihydroxypyrimidine-5-carboxylic acid 23945-44-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

23945-44-0, 2,4-Dihydroxypyrimidine-5-carboxylic acidRelated Search:

5-Fluorouracil 1-Hydroxyethylidene-1,1-diphosphonic acid EPA Stearic acid 1,3-Dihydroxyacetone Ethyl 2-(Chlorosulfonyl)acetate 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Butylated Hydroxytoluene 2,5-PYRIDINEDICARBOXYLIC ACID Folic acid Chrysin Triclosan 2.4-DIHYDROXYPYRIMIDINE-6-CARBOXYLIC ACID MONOHYDRATE,2,4-DIHYDROXYPYRIMIDINE-6-CARBOXYLIC ACID HYDRATE Uracil 6-(HYDROXYMETHYL)URACIL 6-FORMYL-URACIL MONOHYDRATE Citric acid PHOSPHOENOLPYRUVIC ACID TRIS(CYCLOHEXYLAMMONIUM) SALT

1,2,3,4-TETRAHYDRO-2,4-DIOXO-5-PYRIMIDINECARBOXYLIC ACID

2,4-DIHYDROXYPYRIMIDINE-5-CARBOXYLIC ACID

5-CARBOXY-2,4-DIHYDROXYPYRIMIDINE

5-CARBOXYURACIL extrapure

2,4-Dioxo-11,2,3,4-tetrahydropyrimidine-5-carboxylic acid

2,4-Dioxo-1H-pyrimidine-5-carboxylic acid

5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-

1,2,3,6-Tetrahydro-2,6-dioxo-5-pyrimidinecarboxylic acid

2,4-Dioxo-1,3-dihydropyrimidine-5-carboxylic acid

2,4-Dihydroxypyrimidine-5-carboxylic acid hydrate,98%

2,4-Dihydroxypyrimidine-5-carboxylic acid ,98%

2,4-Dihydroxypyrimidine-5-carboxylic acid,Isoorotic acid, Uracil-5-carboxylic acid

2,4-dihydroxypyrimidine-5-carboxylic acid(SALTDATA: FREE)

Uracil-5-carboxylic acid, 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, 5-Carboxy-2,4-dihydroxypyrimidine

NSC 79561

Uracil-5-carboxylic acid, 97+%

ISO-OROTIC ACID

5-Pyrimidinecarboxylic

5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, hydrate

5-CARBOXY-2,4-DIHYDROXYPYRI

2,4-diketo-1H-pyrimidine-5-carboxylic acid

2,4-Dihydroxypyrimidine-5-carboxylic acid anhydrous

URACIL-5-CARBOXYLIC ACID

1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinecarboxylicaci

5-carboxyuracil

Uracil5-carboxylatehydrate

RARECHEM AL BO 2377

URACIL-5-CARBOXYLIC ACID MOMOHYDRATE

Uracil-5-carboxylicacidmonohydrate,98%

Isoorotic Acid, Uracil-5-carboxylic Acid

Uracil-5-Carboxylic

Uracil-5-carboxylic acid, HPLC 98%

2,4-DIHYDROXYPYRIMIDINE-5-CARBOXYLIC ACID HYDRATE 98%

2,4-dihydroxypyrimidine-5-carboxylic acid (uracil-5-carboxylic acid)

Uracil 5-carboxylate

Uracil Impurity 1

uracil-5-carboxylicaci

2,4-Dihydroxypyrimidine-5-carboxylic acid USP/EP/BP

4-Dihydroxypyrimidine-5-carboxylic acid

2,4-Dihydroxypyrimidine-5-formic acid

TIANFUCHEM--23945-44-0--High purity 2,4-Dihydroxypyrimidine-5-carboxylic acid in stock

4F-PV8 reddit/4F-PV8 experience/23945-44-0 discount

2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid (5-carboxyuracil)

2,4-Dihydroxypyrimidin-5-carboxylic acid

2,4-Dihydroxypyrimidine-5-carboxylic acid, 10 mM in DMSO

2,4-DIHYDROXYPYRIMIDINE-5-CARBOXYLIC ACID 98%~101.5%

1,2,3,4-Tetrahydro-2,4-dioxo-pyrimidin-5-carboxylic acid

23945-44-0

23495-44-0

C5H4N2O4xH2O

C4H3N2O2xH2O

Heterocyclic Building Blocks

Pyrimidines

Building Blocks

Heterocycle-Pyrimidine series

Bases & Related Reagents

Nucleotides

Carboxylic Acids