2,4-Dihydroxypyrimidine-5-carboxylic acid
- Product Name
- 2,4-Dihydroxypyrimidine-5-carboxylic acid
- CAS No.
- 23945-44-0
- Chemical Name
- 2,4-Dihydroxypyrimidine-5-carboxylic acid
- Synonyms
- Uracil 5-carboxylate;5-Pyrimidinecarboxylic;URACIL-5-CARBOXYLIC ACID;NSC 79561;ISO-OROTIC ACID;5-carboxyuracil;Uracil Impurity 1;RARECHEM AL BO 2377;Uracil-5-Carboxylic;uracil-5-carboxylicaci
- CBNumber
- CB3327326
- Molecular Formula
- C5H4N2O4
- Formula Weight
- 156.1
- MOL File
- 23945-44-0.mol
2,4-Dihydroxypyrimidine-5-carboxylic acid Property
- Melting point:
- 283 °C (dec.)(lit.)
- Boiling point:
- 280.29°C (rough estimate)
- Density
- 1.6814 (rough estimate)
- refractive index
- 1.4800 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in DMSO
- form
- Crystalline Powder
- pka
- 5.08±0.20(Predicted)
- color
- White to slightly yellow
- Water Solubility
- 1.8g/L(20 ºC)
- InChI
- InChI=1S/C5H4N2O4/c8-3-2(4(9)10)1-6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
- InChIKey
- ZXYAAVBXHKCJJB-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(C(O)=O)C(=O)N1
- CAS DataBase Reference
- 23945-44-0(CAS DataBase Reference)
- EPA Substance Registry System
- 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo- (23945-44-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 126268
- Product name
- 2,4-Dihydroxypyrimidine-5-carboxylic acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $59.9
- Updated
- 2025/07/31
- Product number
- I1020
- Product name
- 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid
- Packaging
- 5G
- Price
- $38
- Updated
- 2025/07/31
- Product number
- I1020
- Product name
- 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid
- Packaging
- 25G
- Price
- $113
- Updated
- 2025/07/31
- Product number
- D494868
- Product name
- 2,4-Dihydroxypyrimidine-5-carboxylic acid
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- OR6297
- Product name
- 2,4-Dihydroxypyrimidine-5-carboxylic acid
- Packaging
- 1g
- Price
- $44
- Updated
- 2021/12/16
2,4-Dihydroxypyrimidine-5-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
white to slightly yellow crystalline powder or
Uses
2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) has been used for the visual sensing of melamine (at parts-per-billion (ppb) level) by a highly sensitive analytical method based on Au nanoparticles.
Definition
ChEBI: Uracil-5-carboxylic acid is a pyrimidinemonocarboxylic acid that is uracil carrying a carboxy group at position 5. It is functionally related to a uracil. It is a conjugate acid of a uracil-5-carboxylate. It is a tautomer of a 2,4-dihydroxypyrimidine-5-carboxylic acid.
General Description
2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) has been obtained from 5-formyluracil by the action of enzyme, thymine 7-hydroxylase. It has been used to synthesize N1-alkylated uracil derivatives.
Synthesis
65-71-4
23945-44-0
The general procedure for synthesizing uracil-5-carboxylic acid from 5-methyluracil was as follows: 100 g of 5-methyluracil and 300 mL of deionized water were added to an autoclave reactor, followed by the addition of 35 mL of a 30% hydrogen peroxide solution. Next, 15 g of 1-hydroxy-1,2,3-benzotriazin-4(3H)-one and 35 g of a pre-prepared catalyst (as described in Example 3) were added. The atmosphere in the autoclave was replaced with oxygen and the reaction system was subsequently heated to 130°C and maintained at this temperature for 3 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and filtered to remove insoluble material. The filtrate was concentrated under reduced pressure and poured into an ice-water mixture for cooling and crystallization, resulting in 150 g of white solid product. The yield of this step was 96.1%, and the purity of the product was 99.3% as analyzed by high performance liquid chromatography (HPLC).
References
[1] Patent: CN108341785, 2018, A. Location in patent: Paragraph 0014-0020
[2] Nucleic Acids Research, 2015, vol. 43, # 20, p. 10026 - 10038
[3] Nucleic Acids Research, 2015, vol. 43, # 20, p. 10026 - 10038
2,4-Dihydroxypyrimidine-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Dihydroxypyrimidine-5-carboxylic acid Suppliers
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View Lastest Price from 2,4-Dihydroxypyrimidine-5-carboxylic acid manufacturers
- Product
- 2,4-Dihydroxypyrimidine-5-carboxylic acid 23945-44-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 2,4-Dihydroxypyrimidine-5-carboxylic acid 23945-44-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2,4-Dihydroxypyrimidine-5-carboxylic acid 23945-44-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09