ChemicalBook > CAS DataBase List > DIGITONIN

DIGITONIN

Product Name
DIGITONIN
CAS No.
11024-24-1
Chemical Name
DIGITONIN
Synonyms
itonin;DIGITIN;igitonin;DIGITONIN;DigitoninGr;5% Digitonin;Digitonin, AR;DIGITONIN(RG);Digitonin USP;DIGITONINE AR
CBNumber
CB3331307
Molecular Formula
C56H92O29
Formula Weight
1229.31
MOL File
11024-24-1.mol
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DIGITONIN Property

Melting point:
230-240 °C (dec.)(lit.)
alpha 
D20 -54° (0.45 g in 15.8 ml methanol)
Boiling point:
788.4°C (rough estimate)
Density 
1.1421 (rough estimate)
refractive index 
-52 ° (C=1, EtOH)
storage temp. 
Sealed in dry,Room Temperature
solubility 
H2O: 10 mg/mL at 95 °C hot, clear, colorless
pka
12.68±0.70(Predicted)
form 
White powder
color 
white
optical activity
[α]20/D 54°, c = 2.8 in methanol(lit.)
biological source
plant seeds (Digitalis purpurea)
Water Solubility 
H2O: ~5% (w/v) (solubilized by heating to 95 °C - 98 °C and then cooling to room temp.)
Merck 
14,3161
BRN 
78654
Stability:
Hygroscopic
InChIKey
FAAZZWIYYDUONB-JYIJKGCVSA-N
EPA Substance Registry System
Digitonin (11024-24-1)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
22-28-36/37-45
RIDADR 
UN 3462 6.1/PG 3
WGK Germany 
3
RTECS 
IH2050050
F 
3-10
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D141
Product name
Digitonin
Purity
Used as non-ionic detergent
Packaging
100mg
Price
$82
Updated
2024/03/01
Sigma-Aldrich
Product number
D141
Product name
Digitonin
Purity
Used as non-ionic detergent
Packaging
500mg
Price
$276
Updated
2024/03/01
TCI Chemical
Product number
D0540
Product name
Digitonin
Packaging
100mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
14952
Product name
Digitonin
Packaging
100mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
14952
Product name
Digitonin
Packaging
1g
Price
$435
Updated
2024/03/01
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DIGITONIN Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

enhances membrane permeability

Uses

Natural surfactant useful for receptor solubilization and cell permeabilization, e.g., blood platelets, hepatocytes, yeast or tumor cells

Uses

Digitonin has been used in a study to assess a procedure for isolating mitochondria from ascites tumor cells. It has also been used in a study to investigate its effect on the cytotoxicity of plant secondary metabolites in cancer cells. This mild nonionic detergent can be used to solubilize receptors and permeabilize cellular and nuclear membranes.

Uses

Clinical reagent (cholesterol determination).

General Description

Crystals or white powder.

Air & Water Reactions

Forms soapy aqueous suspension .

Reactivity Profile

DIGITONIN is incompatible with strong oxidizing agents and strong acids. (NTP, 1992

Fire Hazard

Flash point data for DIGITONIN are not available; however, DIGITONIN is probably combustible.

Biological Activity

Digitonin plays a key role in permeabilizing cell membranes. It is capable of lysing eukaryotic cells but not bacterial membranes. It is also used to solubilize membrane components. It helps to create pores by interacting specifically with cholesterol in the membrane. It is preferred in biotechnology due to its mild detergency. This membrane-active compound act with doxorubicin against multi-drug resistant cancer cells.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Mutation data reported. See also DIGITALIS. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

This digitoxin hexa-glycoside can be recrystallised from aqueous 85% EtOH or MeOH/diethyl ether. It is purified by preparative paper chromatography and developed with the upper phase of a mixture of nBuOH/H2O/AcOH (4:5:1), and the spot (RF 0.36) is eluted with 25% CCl3CO2H in CHCl3. It has also been purified by countercurrent distribution. It forms an ethanolate, and complexes with cholesterol and other sterols. [Ruhenstroth-Bauer & Breitenfeld Hoppe Seyler's Z Physiol Chem 302 111 1955, Grisvold J Am Pharm Assoc 23 664 1934, Beilstein 19 IV 1243.]

DIGITONIN Preparation Products And Raw materials

Raw materials

Preparation Products

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DIGITONIN Suppliers

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View Lastest Price from DIGITONIN manufacturers

Henan Fengda Chemical Co., Ltd
Product
DIGITONIN 11024-24-1
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Career Henan Chemical Co
Product
DIGITONIN 11024-24-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1
Release date
2018-08-06

11024-24-1, DIGITONINRelated Search:

TRIPROPYLENE GLYCOL MONOMETHYL ETHER 2-Methylundecanal dimethylacetal 1,1-Dimethoxydecane LAURYL ALDEHYDE DIMETHYL ACETAL ISOVERTAL 411 L N-OCTYL-BETA-D-GLUCOPYRANOSIDE 2-Octyl-1-dodecanol DIGITONIN Tigogenin HEPTANAL-DIETHYLACETAL 5α-Cholestane CIS-1,2-CYCLOPENTANEDIOL KOHINOOL Dihydrocholesterol (25R)-5ALPHA-SPIROSTAN-2ALPHA,3BETA-DIOL TRIGLYCEROL 3-BUTOXY-PROPIONALDEHYDE DIETHYL ACETAL ISOGRISAL 7 C

  • 25R,5ALPHA-SPIROSTAN-2ALPHA,3BETA,15BETA-TRIOL 3BETA-O-BETA-D-GALACTOPYRANOSYL-(1->3)-O-BETA-D-GALACTYOPYRANOSYL-(1->2)-O-BETA-D-[3-O-BETA-D-XYLOPYRANOSYL]-(1->4)-O-BETA-D-GALACTOPYRANOSIDE
  • DIGITONIN CRYSTALLINE
  • Digitonin, High Purity
  • DIGITONIN (DIGITIN) HIGH PURITY RECEPTOR SOLUBILIZING
  • DigitoninGr
  • Digitonin, AR
  • DIGITONIN, USED AS NON-IONIC DETERGE
  • beta.-D-Galactopyranoside, (2.alpha.,3.beta.,5.alpha.,15.beta.,25R)-2,15-dihydroxyspirostan-3-yl O-.beta.-D-glucopyranosyl-(1?3)-O-.beta.-D-galactopyranosyl-(1?2)-O-.beta.-D-xylopyranosyl-(1?3)-O-.beta.-D-glucopyranosyl-(1?4)-
  • (2.alpha.,3.beta.,5.alpha.,15.beta.,25R)-2,15-dihydroxyspirostan-3-yl O-.beta.-D-glucopyranosyl-(1 .beta.-D-Galactopyranoside
  • DIGITONIN TECH
  • DIGITONIN,CRYSTAL,REAGENT
  • DIGITONIN(RG)
  • (1→3)]-O-β-D-glucopyranosyl-(1→4)- β-D-
  • (2.alpha.,3.beta.,5.alpha.,15.beta.,25R)-2,15-dihydroxyspirostan-3-ylO-.beta.-D-glucopyranosyl-(1.beta.-D-Galactopyranoside
  • beta-d-galactopyranoside,(2alpha,3beta,5alpha,15beta,25theta)-2,15-dihyd
  • osyl-(1.fwdarw.2)-o-[beta-d-xylopyranosyl-(1.fwdarw.3)]-o-beta-d-glucopyranos
  • roxyspirostan-3-ylo-beta-d-glucopyranosyl-(1.fwdarw.3)-o-beta-d-galactopyran
  • yl-(1.fwdarw.4)-
  • Digitonin ,50%
  • 2α,3β,5α,15β,25R)-2,15-dihydroxyspirostan-3-yl-O-β-D-glucopyranosyl-1β-D-Galactopyranoside
  • DIGITIN
  • DIGITONIN
  • DIGITONIN, ALCOHOL-SOLUBLE
  • DIGITONIN WATER SOLUBLE
  • Digitogenin,3-[O-β-D-glucopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-
  • galactopyranoside]
  • Digitonin, approx. 50% (TLC)
  • [(25R)-2α,15β-Dihydroxy-5α-spirostan-3β-yl]4-O-[2-O-[3-O-(β-D-glucopyranosyl)-β-D-galactopyranosyl]-3-O-(β-D-xylopyranosyl)-β-D-glucopyranosyl]-β-D-galactopyranoside
  • Digitonin, approx. 50% (TLC) 500MG
  • Digitonin, approx. 50% (TLC) 5GR
  • DIGITONINANALYTICAL GRADE
  • DIGITONIN WATER SOLUBLERESEARCH GRADE
  • Digitonin,Digitin
  • Digitonin, approx. 50%, water soluble
  • 5% Digitonin
  • Digitonin USP
  • itonin
  • β-D-Galactopyranoside, (2α,3β,5α,15β,25R)-2,15-dihydroxyspirostan-3-yl O-β-D-glucopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-
  • Digitonin (Digitin) extrapure, 50%
  • 3-Benzoxazole-6-carboxylic acid
  • igitonin
  • Digitonin (8CI)
  • Digitonin 99% AR
  • DIGITONINE AR
  • Digitonin, detergent for solubilizing receptors and cellular membranes
  • Digitonin, 10 mM in DMSO
  • 11024-24-1
  • C56H92O29
  • C56H92O28
  • Sterols
  • Lipids
  • Non-Ionic
  • Detergents
  • Conjugates
  • Biochemicals and Reagents
  • BioChemical
  • Surfactants (for Biochemistry)
  • Sugars