ChemicalBook > CAS DataBase List > 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole

2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole

Product Name
2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole
CAS No.
103577-40-8
Chemical Name
2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole
Synonyms
LANSOPRAZOLE SULFIDE;lansoprazole sulphide;K 1252;AG 1777;H 225/18;EC 600-451-9;Lansoprazole-3;2-[3-Methyl-4-(2;2-[3-Methyl-4-(2,2,2;Lansoprazole impurity C
CBNumber
CB3331554
Molecular Formula
C16H14F3N3OS
Formula Weight
353.36
MOL File
103577-40-8.mol
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2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole Property

Melting point:
149-150°C
Boiling point:
494.9±55.0 °C(Predicted)
Density 
1.41
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
10.60±0.10(Predicted)
form 
Crystalline Powder
color 
White to Pale Orange
λmax
292nm(EtOH)(lit.)
InChI
InChI=1S/C16H14F3N3OS/c1-10-13(20-7-6-14(10)23-9-16(17,18)19)8-24-15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChIKey
CCHLMSUZHFPSFC-UHFFFAOYSA-N
SMILES
C1(SCC2=NC=CC(OCC(F)(F)F)=C2C)NC2=CC=CC=C2N=1
CAS DataBase Reference
103577-40-8(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2800
Product name
2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylthio]benzimidazole
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$61
Updated
2025/07/31
TCI Chemical
Product number
M2800
Product name
2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylthio]benzimidazole
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$299
Updated
2025/07/31
TRC
Product number
L175020
Product name
LansoprazoleSulfide
Packaging
50mg
Price
$80
Updated
2021/12/16
TRC
Product number
L175020
Product name
LansoprazoleSulfide
Packaging
500mg
Price
$600
Updated
2021/12/16
Usbiological
Product number
L1277-02
Product name
Lansoprazole Sulfide
Packaging
100mg
Price
$403
Updated
2021/12/16
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2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Lansoprazole Sulfide (Lansoprazole EP Impurity C; USP Impurity B) is a metabolite of Lansoprazole, as gastric pump inhibitor.

Synthesis

128430-66-0

134469-07-1

103577-40-8

2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine (91 g, 0.38 mol) and 1H-benzo[d]imidazole-2-thiol (57 g, 0.38 mol) were used as raw materials, suspended in methanol (1 L), and benzyltributylammonium bromide (2.15 g) was added as a phase transfer catalyst. A 30% NaOH solution (65 mL) was added slowly and dropwise over a period of 1 h, followed by stirring the reaction for 2 h at room temperature. Upon completion of the reaction, water (300 mL) was added to the reaction mixture and stirring was continued for 30 min. The mixture was cooled to 10 °C and the pH was adjusted to 9 with 35% HCl, at which point the target product 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole precipitated as a precipitate. The precipitate was collected by filtration and washed sequentially with 50% methanol and water. Finally, the product was dried under vacuum at 50 °C to give 129 g in 96% yield.

References

[1] Organic Process Research and Development, 2013, vol. 17, # 10, p. 1272 - 1276
[2] Patent: CN106543146, 2017, A. Location in patent: Paragraph 0025; 0031; 0032; 0041; 0045; 0049; 0053-0069
[3] Synthetic Communications, 2002, vol. 32, # 8, p. 1211 - 1217

2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole Suppliers

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View Lastest Price from 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole 103577-40-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-20
Henan Fengda Chemical Co., Ltd
Product
2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole 103577-40-8
Price
US $8.00-1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Qiuxian Baitai New Material Co., LTD
Product
Lansoprazole sulfide 103577-40-8
Price
US $70.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-11-24

103577-40-8, 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazoleRelated Search:

Kresoxim-methyl Methyl acetate Methyl salicylate METSULFURON METHYL 5-Amino-2-methylpyridine 4-Methylpyridine Ethoxymethylenemalononitrile Benzimidazole ISOMETHIOZIN 2-Chloro-5-chloromethylpyridine Azamethiphos Tribenuron methyl 2,6-Lutidine 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride Thiophanate-methyl Methyl 4-Nitro-2,3-lutidine-N-oxide 2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride

  • 2-[[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridine-2-yl]methylthio]-1H-benzoimidazole
  • 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinylmethylthio]-1H-benzoimidazole
  • 2-[3-Methyl-4-(2,2,2
  • Lansoprazole Related Compound B (25 mg) (2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methyl]sulfanyl]-1H-benzimidazole)
  • 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]Methyl}-1H-1,3-benzodiazole-1-thiol
  • 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)Methyl)thio)-1H-benzo[d]iMidazole
  • 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]thio]-
  • 1H-BenziMidazole, 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]thio]-
  • 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl thio-1H-benziMidazole hydrate
  • 2-(((3-METHYL-4(2,2,2-TRIFLUROETHOXY)-2-PYRIDINYL)METHYL)SULFANYL)-1H-BENZIMIDAZOLE
  • Lansoprazole IMpurity-Sulfide (EP-IMpurity C)
  • Lansoprazole EP IMpurity C
  • Lansoprazole Related CoMpound B
  • Lansoprazole related substance C
  • 1-(methylthio)-2-[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]benzimidazole
  • Imp. B (EP):2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]sulphonyl]-1Hbenzimidazole(Lansoprazole Sulphone)
  • Lansoprazole impurity 3/Lansoprazole EP Impurity C/Lansoprazole Sulfide/2-(((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
  • Lansoprazole-3
  • 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)
  • Lansoprazole impurity C
  • lansoprazole sulphide
  • 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylthio]benzimidazole
  • LANSOPRAZOLE SULFIDE
  • 2-[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)-2-PYRIDINYL]METHYL THIO-1H-BENZIMIDAZOLE
  • 2-[[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRID-2YL]METHYLTHIO]BENZIMIDAZOLE
  • 2-((METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINYL)THIO)-1H-BINZIMIDAZOLE
  • 2-[[[3 methyl-4-(2,2,2 trifluoroethoxy) 2-pyridyl]-methyl] thio]-1H-benzimidazole
  • 2-[[(3-Methyl-4-(2,2,2-Trifluoroethoxy) Pyridinyl) Methyl] Thio]-1H-Benzimidazole
  • 2-[[[3-Methyl-4-(2,2,2-Trifluoroethyoxy)-2-Pyridyl]-Methyl]Thio]-1H-Benzimidazole
  • 2-[3-Methyl-4-(2,2,2-Trifluoroethoxy)Methylthio-1H-Benzimidazole
  • 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridinyl)thio)-(1H)-binzimidazole
  • AG 1777
  • H 225/18
  • K 1252
  • Lansoprazole sulphide compound
  • 2-[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)-2-PYRIDINYL ]METHYL THIO-1H-BENZIMIDAZOLE 98+%
  • 2-[(1H-Benzoimidazole-2-yl)thiomethyl]-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine
  • Lansoprazole EP Impurity C/USP Impurity B
  • 2-[3-Methyl-4-(2
  • 2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole
  • Lansoprazole EP Impurity C (Lansoprazole USP Related Compound B)
  • Lansoprazole Impurity 3(Lansoprazole EP Impurity C)
  • Lansoprazole EP Impurity C (Lansoprazole Sulfide)
  • lansoprazole Sulfur ether
  • Dexlansoprazole Impurity 9
  • 2-[[[3-Methyl-4-(2,2,2-trifluoromethoxy)pyrid-2-yl]methyl]thio]benzimidazole
  • LANSOPRAZOLE INTERMEDIATES
  • Dex-Lansoprazole Sulfide/Lansoprazole EP Impurity C
  • Lansoprazole USP Impurity B
  • Lansoprazole EP Impurity C (Sulphide)
  • Lansoprazole EP Impurity C/ Lansoprazole Related Compound B (Lansoprazole Sulfide)
  • 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfanyl]-1H-benzimidazole
  • 2-[[[3 methyl-4-(2,2,2 trifluoroethoxy) 2-pyridyl]-methyl] t...
  • Lansoprazole Sulfide ImpurityQ: What is Lansoprazole Sulfide Impurity Q: What is the CAS Number of Lansoprazole Sulfide Impurity Q: What is the storage condition of Lansoprazole Sulfide Impurity
  • Lansoprazole Related Compound B (2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methyl]sulfan (1356931)
  • Lansoprazole Impurity C（EP）
  • 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridiny]methylthio-1H- benzimidazole
  • EC 600-451-9