BOC-D-Methionine
- Product Name
- BOC-D-Methionine
- CAS No.
- 5241-66-7
- Chemical Name
- BOC-D-Methionine
- Synonyms
- BOC-D-MET;Boc-D-Met-OH;BOC-D-METHIONINE;n-box-d-methionine;N-BOC-D-METHIONINE;Boc-D-methionine99%;BOC-D-Methionine,98%;Boc-
D -Met-OH;N-Boc-D-methionine, 98+%;N-ALPHA-T-BOC-D-METHIONINE - CBNumber
- CB3337192
- Molecular Formula
- C10H19NO4S
- Formula Weight
- 249.33
- MOL File
- 5241-66-7.mol
BOC-D-Methionine Property
- Melting point:
- 47-50 °C
- alpha
- 23 º (c=1.3, methanol)
- Boiling point:
- 415.5±40.0 °C(Predicted)
- Density
- 1.160±0.06 g/cm3(Predicted)
- refractive index
- 22 ° (C=1, MeOH)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- soluble in Methanol
- form
- Powder
- pka
- 3.83±0.10(Predicted)
- color
- White to off-white
- BRN
- 4294122
- CAS DataBase Reference
- 5241-66-7(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 2930 90 98
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 8.53093
- Product name
- Boc-D-Met-OH
- Purity
- Novabiochem?
- Packaging
- 25g
- Price
- $83.4
- Updated
- 2025/07/31
- Product number
- 15132
- Product name
- Boc-D-Met-OH
- Purity
- ≥98.0% (TLC)
- Packaging
- 25g
- Price
- $420
- Updated
- 2025/07/31
- Product number
- 15132
- Product name
- Boc-D-Met-OH
- Purity
- ≥98.0% (TLC)
- Packaging
- 5g
- Price
- $146
- Updated
- 2023/06/20
- Product number
- B2967
- Product name
- N-(tert-Butoxycarbonyl)-D-methionine
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- B2967
- Product name
- N-(tert-Butoxycarbonyl)-D-methionine
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $108
- Updated
- 2025/07/31
BOC-D-Methionine Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
N-Boc-D-methionine is an N-Boc-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
348-67-4
24424-99-5
5241-66-7
(a) Preparation of tert-butoxycarbonyl-D-methionine: D-methionine (50.3 g, 0.34 mol) was dissolved in an aqueous solution (700 mL) containing sodium carbonate (71.5 g, 0.675 mol). To this solution was slowly added a solution of di-tert-butyl dicarbonate (81.0 g, 0.37 mol) in dioxane (250 mL), and the reaction mixture was stirred and reacted at room temperature for 16 hours. Upon completion of the reaction, it was diluted by adding water (1.5 L) and washed twice with ether (2 × 500 mL) to remove unreacted feedstock. Subsequently, the aqueous phase was acidified to pH 3 by addition of solid citric acid and the product was extracted with ethyl acetate (3 × 500 mL). The organic phases were combined, washed sequentially with water (2 × 500 mL) and saturated brine (500 mL), and finally dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford tert-butoxycarbonyl-D-methionine as a colorless oil (87.6 g, 100% yield). The specific optical rotation of the product was [α]D +19.0° (c = 1%, methanol).
References
[1] Patent: US4863953, 1989, A
[2] Journal of the Chemical Society - Series Chemical Communications, 1989, # 22, p. 1740 - 1742
[3] Journal of Organic Chemistry, 1999, vol. 64, # 14, p. 5166 - 5175
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4815 - 4830
BOC-D-Methionine Preparation Products And Raw materials
Raw materials
Preparation Products
BOC-D-Methionine Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
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- Tel
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- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
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- Advantage
- 30
- Tel
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- Country
- United Kingdom
- ProdList
- 6309
- Advantage
- 46
- Tel
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- Fax
- --
- solutions@vwr.com
- Country
- United Kingdom
- ProdList
- 6548
- Advantage
- 82
View Lastest Price from BOC-D-Methionine manufacturers
- Product
- Boc-D-Met-OH 5241-66-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2023-11-16
- Product
- BOC-D-Methionine 5241-66-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-16