BOC-D-Methionine

Product Name: BOC-D-Methionine
CAS No.: 5241-66-7
Chemical Name: BOC-D-Methionine
Synonyms: BOC-D-MET;Boc-D-Met-OH;BOC-D-METHIONINE;n-box-d-methionine;N-BOC-D-METHIONINE;Boc-D-methionine99%;BOC-D-Methionine,98%;Boc-D-Met-OH;N-Boc-D-methionine, 98+%;N-ALPHA-T-BOC-D-METHIONINE
CBNumber: CB3337192
Molecular Formula: C10H19NO4S
Formula Weight: 249.33
MOL File: 5241-66-7.mol

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BOC-D-Methionine Property

Melting point:: 47-50 °C
alpha: 23 º (c=1.3, methanol)
Boiling point:: 415.5±40.0 °C(Predicted)
Density: 1.160±0.06 g/cm3(Predicted)
refractive index: 22 ° (C=1, MeOH)
storage temp.: Sealed in dry,2-8°C
solubility: soluble in Methanol
form: Powder
pka: 3.83±0.10(Predicted)
color: White to off-white
BRN: 4294122
CAS DataBase Reference: 5241-66-7(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 2930 90 98

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53093
Product name: Boc-D-Met-OH
Purity: Novabiochem?
Packaging: 25g
Price: $83.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15132
Product name: Boc-D-Met-OH
Purity: ≥98.0% (TLC)
Packaging: 25g
Price: $420
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15132
Product name: Boc-D-Met-OH
Purity: ≥98.0% (TLC)
Packaging: 5g
Price: $146
Updated: 2023/06/20

TCI Chemical

Product number: B2967
Product name: N-(tert-Butoxycarbonyl)-D-methionine
Purity: >95.0%(HPLC)(T)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: B2967
Product name: N-(tert-Butoxycarbonyl)-D-methionine
Purity: >95.0%(HPLC)(T)
Packaging: 25g
Price: $108
Updated: 2025/07/31

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BOC-D-Methionine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-D-methionine is an N-Boc-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

348-67-4

24424-99-5

5241-66-7

(a) Preparation of tert-butoxycarbonyl-D-methionine: D-methionine (50.3 g, 0.34 mol) was dissolved in an aqueous solution (700 mL) containing sodium carbonate (71.5 g, 0.675 mol). To this solution was slowly added a solution of di-tert-butyl dicarbonate (81.0 g, 0.37 mol) in dioxane (250 mL), and the reaction mixture was stirred and reacted at room temperature for 16 hours. Upon completion of the reaction, it was diluted by adding water (1.5 L) and washed twice with ether (2 × 500 mL) to remove unreacted feedstock. Subsequently, the aqueous phase was acidified to pH 3 by addition of solid citric acid and the product was extracted with ethyl acetate (3 × 500 mL). The organic phases were combined, washed sequentially with water (2 × 500 mL) and saturated brine (500 mL), and finally dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford tert-butoxycarbonyl-D-methionine as a colorless oil (87.6 g, 100% yield). The specific optical rotation of the product was [α]D +19.0° (c = 1%, methanol).

References

[1] Patent: US4863953, 1989, A
[2] Journal of the Chemical Society - Series Chemical Communications, 1989, # 22, p. 1740 - 1742
[3] Journal of Organic Chemistry, 1999, vol. 64, # 14, p. 5166 - 5175
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4815 - 4830

BOC-D-Methionine Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-Methionine Suppliers

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View Lastest Price from BOC-D-Methionine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-D-Met-OH 5241-66-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-16

Career Henan Chemical Co

Product: BOC-D-Methionine 5241-66-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-16

5241-66-7, BOC-D-MethionineRelated Search:

1,1'-Carbonyldiimidazole tert-Butanol Zinc methionine sulfate L-Methionine N-Carbobenzyloxyglycine DL-Methionine S-ADENOSYL-L-METHIONINE 2-Chloro-2-methylpropane D-Methionine BOC-HYP-OL N-Boc-L-Phenylalaninol N-Boc-exo-3-aminotropane N-Boc-D-Phenylalaninol N-Boc-L-Homoserine BOC-D-ALPHA-T-BUTYLGLYCINE N-Boc-D-Valino Boc-Lys-OH NICKEL CARBONYL

BOC-D-METHIONINE

BOC-D-MET

N-(TERT-BUTOXYCARBONYL)-D-METHIONIN

N-(TERT-BUTOXYCARBONYL)-D-METHIONINE

N-BOC-D-METHIONINE

N-ALPHA-T-BOC-D-METHIONINE

N-ALPHA-T-BUTYLOXYCARBONYL-D-METHIONINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-D-METHIONINE

T-BUTYLOXYCARBONYL-D-METHIONINE

Boc-D-Met-OH

n-box-d-methionine

N-Boc-D-methionine, 98+%

(2R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid

D-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-

N-(tert-butyloxycarbonyl)-D-methionine

N-[(1,1-Dimethylethoxy)carbonyl]-D-methionine

BOC-D-Methionine,98%

N-Boc-D-methionine Boc-D-Met-OH

(2R)-2-[(tert-Butoxycarbonyl)amino]-4-(methylsulphonyl)butanoic acid

D-Methionine, N-BOC protected

BOC-D-Methionine(Boc-D-Met-OH)

(R)-2-((tert-butoxycarbonyl)aMino)-4-(Methylthio)butanoic acid

(Tert-Butoxy)Carbonyl D-Met-OH

Boc-D-methionine99%

(2R)-2-{[(tert-butoxy)carbonyl]amino}-4-(methylsulfanyl)butanoic acid

(2R)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-(methylthio)butanoate

N-(tert-Butoxycarbonyl)-D-methionine &gt

BOC-D-Methionine USP/EP/BP

Boc-<sc>D</sc>-Met-OH

5241-66-7

Amino Acid Derivatives

Methionine

Peptide Synthesis

Specialty Synthesis

Amino Acids (N-Protected)

Biochemistry

Boc-Amino Acids

Methionine [Met, M]

Amino Acid Derivatives

Amino Acids