1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

Product Name: 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
CAS No.: 1837-91-8
Chemical Name: 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
Synonyms: NSC 7908;JAK2 INHIBITOR II;BENZENE HEXABROMIDE;6-Hexabromocyclohexane;trans-α-Benzene hexabromide;1,2,3,4,5,6-Hexabromcyclohexan;1,2,3,4,5,6-HEXABROMOCYCLOHEXANE;1,2,3,4,5,6-hexabromo-cyclohexan;Cyclohexane, 1,2,3,4,5,6-hexabromo-;JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem
CBNumber: CB3337703
Molecular Formula: C6H6Br6
Formula Weight: 557.54
MOL File: 1837-91-8.mol

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1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Property

Melting point:: 218.0 to 223.0 °C
storage temp.: Store at RT
solubility: DMSO: soluble2mg/mL (clear solution, warmed)
form: powder
color: white to beige
CAS DataBase Reference: 1837-91-8(CAS DataBase Reference)
EPA Substance Registry System: Cyclohexane, 1,2,3,4,5,6-hexabromo- (1837-91-8)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-36-22
Safety Statements: 26-36/37/39
WGK Germany: 3
TSCA: Yes

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 420132
Product name: JAK2 Inhibitor II
Packaging: 25mg
Price: $172
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0455
Product name: 1,2,3,4,5,6-Hexabromocyclohexane
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $127
Updated: 2022/05/15

TCI Chemical

Product number: H0368
Product name: 1,2,3,4,5,6-Hexabromocyclohexane
Packaging: 5g
Price: $326
Updated: 2021/12/16

TCI Chemical

Product number: H0368
Product name: 1,2,3,4,5,6-Hexabromocyclohexane
Purity: min. 97.0 %
Packaging: 1G
Price: $109
Updated: 2021/12/16

Alfa Aesar

Product number: J60853
Product name: 1,2,3,4,5,6-Hexabromocyclohexane
Packaging: 1g
Price: $99.65
Updated: 2024/03/01

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1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Chemical Properties,Usage,Production

Uses

1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.

Definition

ChEBI: 1,2,3,4,5,6-hexabromocyclohexane is a bromohydrocarbon that is cyclohexane in which the hydrogen at positions 1,2,3,4,5 and 6 have been replaced by bromo groups. It is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a bromohydrocarbon and a bromoalkane. It derives from a hydride of a cyclohexane.

Biological Activity

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M.

storage

Room temperature

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Suppliers

Americas 1 Canada 1 China 28 Germany 2 India 2 Japan 1 Norway 1 United Kingdom 5 United States 13 USA 1 Global 55

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View Lastest Price from 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE 1837-91-8
Price: US $101.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-28

1837-91-8, 1,2,3,4,5,6-HEXABROMOCYCLOHEXANERelated Search:

1,2,5,6-TETRABROMOHEXANE 1,5-Dibromopentane 3,4-DIBROMOHEXANE 1,2,3,4-Tetrabromobutane 2,4-DIBROMOPENTANE 1,2,4-Tribromobutane 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE 1,3-Dibromobutane 2,5-Dibromohexane TRANS-1,2-DIBROMOCYCLOHEXANE 1,2-DIBROMOCYCLOHEXANE 1,2-Dibromobutane 1,4-Dibromopentane 2,3-DIBROMOBUTANE Bromocyclohexane 1,4-Dibromobutane 1,2,3-Tribromopropane 1,2-Dibromopentane

1,2,3,4,5,6-hexabromo-cyclohexan

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

BENZENE HEXABROMIDE

JAK2 INHIBITOR II

trans-α-Benzene hexabromide

1,2,3,4,5,6-Hexabromcyclohexan

NSC 7908

JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem

Cyclohexane, 1,2,3,4,5,6-hexabromo-

6-Hexabromocyclohexane

1,2,3,4,5,6Hexabromocyclohexane,1,2,3,4,5,6 Hexabromocyclohexane

1837-91-8

C6H6Br6