5-Trifluoromethyl-2-oxindole

ChemicalBook > CAS DataBase List > 5-Trifluoromethyl-2-oxindole

5-Trifluoromethyl-2-oxindole

Preparation

Product Name: 5-Trifluoromethyl-2-oxindole
CAS No.: 71293-62-4
Chemical Name: 5-Trifluoromethyl-2-oxindole
Synonyms: 5-(TRIFLUOROMETHYL)OXINDOLE;5-Trifluoromethyl-2-oxindole;5-(Trifluoromethyl)oxindole97%;5-(Trifluoromethyl)oxindole 97%;5-(Trifluoromethyl)-2-oxoindole;5-(Trifluoromethyl)indolin-2-one;5-(TRIFLUOROMETHYL)OXINDOLE ,98%;5-(Trifluoromethyl)-2-oxindole97%;5-(Trifluoromethyl)-2-oxindole 97%;5-(Trifluoromethyl)-1,3-dihydroindol-2-one
CBNumber: CB3341087
Molecular Formula: C9H6F3NO
Formula Weight: 201.15
MOL File: 71293-62-4.mol

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5-Trifluoromethyl-2-oxindole Property

Melting point:: 182-186
Boiling point:: 283.4±40.0 °C(Predicted)
Density: 1.391±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform, DMSO, Methanol (Slightly)
form: Solid
pka: 13.35±0.20(Predicted)
color: Light Brown to Dark Yellow
CAS DataBase Reference: 71293-62-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
Hazard Note: Irritant/Keep Cold
HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: T899643
Product name: 5-(Trifluoromethyl)indolin-2-one
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T899643
Product name: 5-(Trifluoromethyl)indolin-2-one
Packaging: 100mg
Price: $85
Updated: 2021/12/16

TRC

Product number: T899643
Product name: 5-(Trifluoromethyl)indolin-2-one
Packaging: 500mg
Price: $280
Updated: 2021/12/16

Matrix Scientific

Product number: 188951
Product name: 5-(Trifluoromethyl)indolin-2-one
Packaging: 1g
Price: $314
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-3-X9
Product name: 5-(Trifluoromethyl)oxindole
Purity: 97%
Packaging: 1g
Price: $378
Updated: 2021/12/16

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5-Trifluoromethyl-2-oxindole Chemical Properties,Usage,Production

Preparation

STEP A:Preparation of 5-trifluoromethyl-3-methylthio-oxindole To a solution of 15.4 g of p-trifluoromethylaniline in 400 ml. of methylene chloride cooled to minus 65℃. is added dropwise a solution of 10.2 g of t-butyl hypo chlorite in 20 ml. of methylene chloride. The solution is stirred at minus 65℃. for 5 minutes and there is then added dropwise 13.0 g of thioacetic acid ethyl ester in 20 ml of methylene chloride. The resulting mixture is stirred at minus 65℃. for 30 minutes. There is then slowly added 9.8 g of triethylamine and the reaction mixture allowed to warm to room temperature at which time 200 ml of 2 N. hydrochloric acid is added fol lowed by stirring overnight at room temperature. There is then added 20 ml of saturated sodium sulfite solution, the mixture stirred for 15 minutes, the aqueous phase separated and extracted into 1 N sodium hydroxide solution and treated with 6 N. hydrochloric acid to obtain a precipitate. The precipitate is then extracted into methylene chloride, dried, filtered and the methy lene chloride exchanged for ether and then pentane added to obtain 5-trifluoromethyl-3-methylthio-oxin dole, m.p. 136-138℃.STEP B: Preparation of 5-trifluoromethyl-oxindole A mixture of 4.0 g of 5-trifluoromethyl-3-methylthio oxindole, 20g of Raney Nickel and 100 ml. of methanol is refluxed for 4 days, cooled, treated with methylene chloride, filtered to remove the Raney Nickel and the filtrate concentrated in vacuo to obtain 5-trifluorometh yl-oxindole, m.p. 188-190℃.

Uses

5-(Trifluoromethyl)indolin-2-one is a useful reagent for the preparation of 3-Chloro-α-carbolines.

5-Trifluoromethyl-2-oxindole Preparation Products And Raw materials

Raw materials

Preparation Products

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71293-62-4, 5-Trifluoromethyl-2-oxindoleRelated Search:

(Trifluoromethyl)trimethylsilane Trifluoromethanesulfonic anhydride 3-（trifluoromethyl) Cinnamaldehyde 2-Methylbenzotrifluoride 3-(Trifluoromethyl)benzoic acid 3-(Trifluoromethyl)benzaldehyde Oxindole 5-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 5-(TRIFLUOROMETHYL)NICOTINONITRILE 5-TRIFLUOROMETHYLBENZOTHIAZOLE 6-TRIFLUOROMETHYLOXINDOLE 2-Methyl-4-(trifluoromethyl) aniline 5-(TRIFLUOROMETHYL)ISATIN 5-Trifluoromethylindoline Trifluoromethyl 5-Trifluoromethyl-2-oxindole

5-(Trifluoromethyl)-2-oxoindole

5-(TRIFLUOROMETHYL)OXINDOLE

5-(Trifluoromethyl)oxindole 97%

5-(Trifluoromethyl)oxindole97%

5-(TRIFLUOROMETHYL)OXINDOLE ,98%

5-(Trifluoromethyl)indolin-2-one

5-(Trifluoromethyl)-2-oxindole 97%

5-(Trifluoromethyl)indolin-2-one, 1,3-Dihydro-5-(trifluoromethyl)-2H-indol-2-one

5-(Trifluoromethyl)-2-oxindole97%

5-(Trifluoromethyl)-1,3-dihydroindol-2-one

5-Trifluoromethyl-2-oxindole

2H-Indol-2-one, 1,3-dihydro-5-(trifluoromethyl)-

71293-62-4

Boronic Acid

Heterocyclic Compounds

Indoline & Oxindole

Indoles

blocks

FluoroCompounds

IndolesOxindoles

Indole/indoline/oxindole