ChemicalBook > CAS DataBase List > 2'-(Trifluoromethyl)acetophenone

2'-(Trifluoromethyl)acetophenone

Product Name: 2'-(Trifluoromethyl)acetophenone
CAS No.: 17408-14-9
Chemical Name: 2'-(Trifluoromethyl)acetophenone
Synonyms: 2-ACETYLBENZOFLUORIDE;2-ACETYLBENZOTRIFLUORIDE;2-(trifluoromethyl) hypnone;O-TRIFLUOROMETHYLACETOPHENONE;2-(TRIFLUOROMETHYL)ACETOPHENONE;2'-(trifluoromethyl)acetophenone;Acetophenone, 2'-trifluoromethyl-;2'-(Trifluoromethyl)acetophenone98%;2'-(Trifluoromethyl)acetophenone 98%;2'-(Trifluoromethyl)acetophenone,99%
CBNumber: CB3341401
Molecular Formula: C9H7F3O
Formula Weight: 188.15
MOL File: 17408-14-9.mol

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2'-(Trifluoromethyl)acetophenone Property

Melting point:: 15-17°C
Boiling point:: 163 °C
Density: 1.255 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4584(lit.)
Flash point:: 184 °F
storage temp.: 2-8°C
form: Liquid
Specific Gravity: 1.255
color: Clear colorless to very slightly yellow
BRN: 2259035
CAS DataBase Reference: 17408-14-9(CAS DataBase Reference)
NIST Chemistry Reference: 2'-(Trifluoromethyl)acetophenone(17408-14-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-24/25-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29143990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 233153
Product name: 2′-(Trifluoromethyl)acetophenone
Purity: 99%
Packaging: 5g
Price: $20.44
Updated: 2025/07/31

TCI Chemical

Product number: T1899
Product name: 2'-(Trifluoromethyl)acetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $58
Updated: 2025/07/31

TRC

Product number: T797173
Product name: 2''-(Trifluoromethyl)acetophenone
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC7470
Product name: 2'-(Trifluoromethyl)acetophenone
Purity: 98%
Packaging: 25g
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 006491
Product name: 2'-(Trifluoromethyl)acetophenone
Purity: 99%
Packaging: 25g
Price: $50
Updated: 2021/12/16

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2'-(Trifluoromethyl)acetophenone Chemical Properties,Usage,Production

Chemical Properties

clear colorless to very slightly yellow liqui

Uses

2′-(Trifluoromethyl)acetophenone has been used to investigate the use of in situ generated CuCF₃ for the direct substitution of chlorine by CF₃ in various aromatic substrates.

Synthesis

79756-81-3

17408-14-9

The general procedure for the synthesis of o-trifluoromethylacetophenone using 1-(2-trifluoromethylphenyl)ethanol as starting material was as follows: in a round-bottomed flask, which was pre-dried in an oven, eosin Y (5 mmol), 1-(2-trifluoromethylphenyl)ethanol (1 mmol), and 3 equiv. of TBHP (5.5 M solution in decane, with the solvent being dry acetonitrile (ACN) were added. The resulting mixture was degassed for 15 min and subsequently backfilled with nitrogen. Next, the mixture was irradiated at room temperature (25 °C) using a blue LED lamp (12 W, 455 nm). The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was diluted with 15 mL of 10% NaHCO3 solution and extracted with ethyl acetate (EtOAc, 3 × 20 mL). The organic extracts were combined, washed with brine (20 mL), dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under vacuum. Finally, the crude product was purified by silica gel column chromatography using ethyl acetate:hexane as eluent to obtain the target product o-trifluoromethyl acetophenone.

References

[1] ChemCatChem, 2015, vol. 7, # 12, p. 1865 - 1870
[2] Tetrahedron Letters, 2016, vol. 57, # 30, p. 3294 - 3297
[3] Green Chemistry, 2017, vol. 19, # 2, p. 474 - 480

2'-(Trifluoromethyl)acetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-(Trifluoromethyl)acetophenone Suppliers

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View Lastest Price from 2'-(Trifluoromethyl)acetophenone manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 2'-(Trifluoromethyl)acetophenone 17408-14-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2"-(Trifluoromethyl)acetophenone 17408-14-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 2'-(Trifluoromethyl)acetophenone 17408-14-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-12

17408-14-9, 2'-(Trifluoromethyl)acetophenoneRelated Search:

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2-ACETYLBENZOFLUORIDE

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2-(TRIFLUOROMETHYL)ACETOPHENONE

O-TRIFLUOROMETHYLACETOPHENONE

1-[2-(Trifluoromethyl)phenyl]ethanone

Acetophenone, 2'-trifluoromethyl-

Ethanone, 1-[2-(trifluoromethyl)phenyl]-

2-(trifluoromethyl) hypnone

2'-(Trifluoromethyl)acetophenone 98%

2'-(Trifluoromethyl)acetophenone98%

1-[2-(trifluoromethyl)phenyl]ethan-1-one

2'-(Trifluoromethyl)acetophenone, 97+%

2'-(Trifluoromethyl)acetophenone,99%

2'-(trifluoromethyl)acetophenone

2′-(Trifluoromethyl)acetophenone, CAS 17408-14-9

17408-14-9

C9H7OF3

C9H7F3O

C9H7F30

Ketones

Organic Building Blocks

KETONE

Building Blocks

Carbonyl Compounds

Fluorine series

Benzenes

Carbonyl Compounds

Ketones

Aromatic Acetophenones & Derivatives (substituted)

Boronic Acid series

Fluorobenzene

Carbonyl Compounds