1-Boc-pyrazole-4-boronic acid pinacol ester

Product Name: 1-Boc-pyrazole-4-boronic acid pinacol ester
CAS No.: 552846-17-0
Chemical Name: 1-Boc-pyrazole-4-boronic acid pinacol ester
Synonyms: tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate;tert-butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate;EOS-60399;1-Boc-4-pyrazo;1-Boc-4-pyrazoL;1-BOC- 4-PYRAZOLEBORONIC ACID PINACOL ESTER;N-BOC-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Boc-pyrazole-4-boronic acid pinacol ester;N-Boc-pyrazole-4-boronic acid pinaxcol ester;1-Boc-pyrazolyl-4-boronic Acid Pinacol Ester
CBNumber: CB3341441
Molecular Formula: C14H23BN2O4
Formula Weight: 294.15
MOL File: 552846-17-0.mol

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1-Boc-pyrazole-4-boronic acid pinacol ester Property

Melting point:: 82-86 °C (lit.)
Boiling point:: 387.9±34.0 °C(Predicted)
Density: 1.09±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Methanol
pka: -1.20±0.12(Predicted)
form: Crystalline Powder
color: White to beige
Water Solubility: insoluble
InChI: InChI=1S/C14H23BN2O4/c1-12(2,3)19-11(18)17-9-10(8-16-17)15-20-13(4,5)14(6,7)21-15/h8-9H,1-7H3
InChIKey: IPISOFJLWYBCAV-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)C=C(B2OC(C)(C)C(C)(C)O2)C=N1

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 22-24/25-37/39-26
WGK Germany: 3
HS Code: 29339900
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5203
Product name: 1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(T)
Packaging: 1g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: B5203
Product name: 1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(T)
Packaging: 5g
Price: $120
Updated: 2025/07/31

TRC

Product number: B665190
Product name: 1-Boc-pyrazole-4-boronic acid pinacol ester
Packaging: 25g
Price: $790
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0000854
Product name: 1-BOC-PYRAZOLE-4-BORONIC ACID PINACOL ESTER
Purity: 95.00%
Packaging: 5G
Price: $969.05
Updated: 2021/12/16

Oakwood

Product number: 037047
Product name: 1-Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Packaging: 10g
Price: $64
Updated: 2021/12/16

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1-Boc-pyrazole-4-boronic acid pinacol ester Chemical Properties,Usage,Production

Chemical Properties

white to beige crystalline powder

Uses

1-Boc-pyrazole-4-boronic Acid Pinacol Ester is used as a reagent in the synthesis of several inhibitors including thieno[3,2-c]pyridin-4-amines which are a novel series of Bruton’s tyrosine kinase (BTK) inhibitors which can be used in drug design.

Synthesis

269410-08-4

24424-99-5

552846-17-0

4-Pyrazoleboronic acid pinacol ester (1.16 g, 6.0 mmol) and di-tert-butyl dicarbonate (1.58 g, 7.2 mmol) were used as raw materials and dissolved in dichloromethane (40 mL). A catalytic amount of 4-dimethylaminopyridine (102 mg, 0.84 mmol) was added and the reaction was stirred at room temperature for 4 hours. After completion of the reaction, water was added to the reaction system and extracted with ethyl acetate. The organic phase was washed with saturated aqueous sodium chloride solution and then the solvent was removed by rotary evaporation to give the crude product 1-Boc-pyrazole-4-boronic acid pinacol ester (1.5 g, 85% yield).

References

[1] Patent: CN103936728, 2016, B. Location in patent: Paragraph 0177; 0203; 0204; 0205
[2] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 68
[3] Patent: WO2018/154466, 2018, A1. Location in patent: Paragraph 001162; 001164; 001165
[4] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 58
[5] Patent: WO2004/56727, 2004, A2. Location in patent: Page 97

1-Boc-pyrazole-4-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-pyrazole-4-boronic acid pinacol ester Suppliers

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View Lastest Price from 1-Boc-pyrazole-4-boronic acid pinacol ester manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-Boc-4-pyrazoleboronic Acid Pinacol Ester 552846-17-0
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-05

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Boc-pyrazole-4-boronic acid pinacol ester 552846-17-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Boc-pyrazole-4-boronic acid pinacol ester 552846-17-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

552846-17-0, 1-Boc-pyrazole-4-boronic acid pinacol esterRelated Search:

1,1'-Carbonyldiimidazole BUTYL OLEATE 2-Chloro-2-methylpropane Pyraclostrobin Tris(trimethylsilyl)phosphate Methyl acrylate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Zolpidem tartrate Pyrazole tert-Butanol NICKEL CARBONYL Zolpidem Carbonyl iron powder 1-Methyl-1H-pyrazole-4-boronic acid 1-Methyl-4-pyrazole boronic acid pinacol ester 1H-PYRAZOLE-4-BORONIC ACID 1-tert-Butoxycarbonyl-1H-pyrazole-4-boronic acid 4-Pyrazoleboronic acid pinacol ester

1-Boc-4-pyrazoleboronic acid pinacol ester, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-Boc-pyrazole, tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-pyrazolecarboxylate

TERT-BUTYL 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE CARBOX., 97%

1-tert-Butoxycarbonyl-4-1H-pyrazoleboronic acid

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylic acid tert-butyl e

1-BOC-PYRAZOLE-4-BORONIC ACID PINACOL ESTER, 97%

1-TERT-BUTOXYCARBONYL-4-1H-PYRAZOLBORONIC ACID PINACOL ESTER

N-Boc-pyrazole-4-boronic acid pinaxcol ester

1-BOC- 4-PYRAZOLEBORONIC ACID PINACOL ESTER

1-BOC-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate

1-Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole ,97%

1H-Pyrazole-4-boronic acid, pinacol ester, N1-BOC protected

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-Bocpyrazole

tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-pyrazolecarboxylate

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylic acid tert-butyl ester

4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-TERT-BUTOXYCARBONYL-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER

1-TERT-BUTOXYCARBONYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER

1-BOC-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRAZOLE

1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-BOC-1H-pyrazol-4-boronic acid pinacol ester

4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-carboxylic acid tert-butyl ester

1H-Pyrazole-1-carboxylic acid,4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-,1,1-dimethylethyl ester

1-Boc-pyrazole-4-boronic acid pinacol ester 1-tert-Butoxycarbonyl-1H-pyrazole-4-boronic acid pinacol ester

1,1-dimethylethyl ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-Pyrazole-1-carboxylic acid

1-tert-Butoxycarbonyl-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrazole

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylic acid ter

tert-butyl 4-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boryl)-1H-pyrazole-1-carboxylate

tert-butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate

1-N-Boc-pyrazole-4-boronic acid pinacol ester

N-BOC-PYRAZOLE-4-BORONIC ACID PINACOL ESTER

1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate

N-Boc-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-pyrazole

1-Boc-pyrazole-4-boronic acid pinacol ester 97%

1-(<i>tert</i>-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

(1-(TERT-BUTOXYCARBONYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER

EOS-60399

1-Boc-4-pyrazo

1-Boc-4-pyrazoL

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate

1-(tert-Butoxycarbonyl)pyrazolyl-4-boronic Acid Pinacol Ester

1-Boc-pyrazolyl-4-boronic Acid Pinacol Ester

2-(1-tert-Butoxycarbonyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

552846-17-0 1-Boc-pyrazole-4-boronic acid pinacol ester

TERT-BUTYL 4-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRAZOLE-1-CARBOXYLATE

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-carboxylate

6-(tert-butyl 4-(tetramethyl-1 ,3,2- dioxaborolan-2-yl)- 1H-pyrazole- 1-carboxylate

Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate - [T8967]

1-Boc-pyrazole-4-boronic acid pinacol ester

1-Boc-pyrazol-4-ylboronic acid pinacol ester

552846-17-0

552846-17-

C14H23BN2O4

Boric Acid| Boric Acid Ester| Potassium Trifluoroborate