A-SPINASTEROL
- Product Name
- A-SPINASTEROL
- CAS No.
- 481-18-5
- Chemical Name
- A-SPINASTEROL
- Synonyms
- -amine D2;Hitdesterol;spinasterol;BESSISTEROL;HITODESTEROL;A-SPINASTEROL;α-Spinasterol;SPINASTEROL, A-;alpha-Spinastero;alpha-spinasterin
- CBNumber
- CB3347160
- Molecular Formula
- C29H48O
- Formula Weight
- 412.69
- MOL File
- 481-18-5.mol
A-SPINASTEROL Property
- Melting point:
- 168-169°
- alpha
- D25 -3.6° (c = 2.8 in chloroform)
- Boiling point:
- 500.0±44.0 °C(Predicted)
- Density
- 0.98±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 15.10±0.70(Predicted)
- color
- White to Off-White
- biological source
- Aster scaber
- Stability:
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- 14197
- Product name
- α-Spinasterol
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 14197
- Product name
- α-Spinasterol
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $55
- Updated
- 2024/03/01
- Product number
- 14197
- Product name
- α-Spinasterol
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 14197
- Product name
- α-Spinasterol
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $197
- Updated
- 2024/03/01
- Product number
- 4729
- Product name
- alpha-Spinasterol
- Purity
- ≥95%(HPLC)
- Packaging
- 1
- Price
- $113
- Updated
- 2021/12/16
A-SPINASTEROL Chemical Properties,Usage,Production
Uses
α-Spinasterol was identified as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties.
Definition
ChEBI: Alpha-Spinasterol is a steroid. It derives from a hydride of a stigmastane.
Biological Activity
α-Spinasterol is a blood-brain barrier-permeable and orally active plant phytosterol with antioxidant, anticonvulsant (0.1-1 mg/kg i.p. in mice), antidepressant (1-2 mg/kg i.p. in mice) and anti-inflammatory (0.001-1 mg/kg, i.p. or 1-10 mg/kg, i.g. in mice) properties, as well as antinociceptive efficacy via dual actions against transient receptor potential vanilloid 1 (TrpV1; IC50/Emax = 1.4 μM/67% against 2 nM RTX for binding mouse spinal cord membranes; IC50/Emax = 40 μM/62% against 20 μM capsaicin-induced mouse spinal cord synaptosomes Ca2+ influx) and cyclooxygenases (IC50 = 16.17 μM/COX1 and 7.76μM/COX2). a-spinasterol can directly affect membrane structure and packing in a manner similar to cholesterol, both a-spinasterol and stitosterol are reported to lower plasma/liver cholesterol levels and increase fecal cholesterol excretion when supplemented in daily diet (1%) in mice in vivo.', 'α-Spinasterol is a constituent of argan oil. It regulates nuclear receptors expression and modulates mitochondrial function. It mimics natural cholesterol and its functionality. α-Spinastero lelicits cytoprotective and antiulcerogenic functionality. It has therapeutic potential towards diabetic nephropathy.
target
TRPV | HMG-CoA reductase
A-SPINASTEROL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from A-SPINASTEROL manufacturers
- Product
- A-SPINASTEROL 481-18-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-03