ChemicalBook > CAS DataBase List > Ropivacaine mesylate

Ropivacaine mesylate

Product Name: Ropivacaine mesylate
CAS No.: 854056-07-8
Chemical Name: Ropivacaine mesylate
Synonyms: ROPIVACAINE MESYLATE;Ropivacaine Mesylate API;Ropivacaine mesylate USP/EP/BP;Ropivacaine Mesylate Injection;TIANFUCHEM--854056-07-8--Ropivacaine mesylate in stock;(S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamidemethanesulfonate;S-(-)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamidemethanesulfonate;(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate;Ropivacaine mesylate (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate
CBNumber: CB3353781
Molecular Formula: C18H30N2O4S
Formula Weight: 370.51
MOL File: 854056-07-8.mol

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Ropivacaine mesylate Property

storage temp.: Store at -20°C
form: Solid
color: White to off-white
Water Solubility: Water: 250 mg/mL (674.75 mM)
InChI: InChI=1/C17H26N2O.CH4O3S/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;1-5(2,3)4/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H3,(H,2,3,4)/t15-;/s3
InChIKey: YPTSIOMXZOPKAF-AVAJOTNLNA-N
SMILES: S(O)(=O)(=O)C.C([C@@H]1CCCCN1CCC)(=O)NC1C(=CC=CC=1C)C |&1:6,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: J50762
Product name: Ropivacainemesylate
Packaging: 1g
Price: $11
Updated: 2021/12/16

ChemScene

Product number: CS-0099282
Product name: Ropivacaine(mesylate)
Purity: ≥98.0%
Packaging: 10mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0099282
Product name: Ropivacaine(mesylate)
Purity: ≥98.0%
Packaging: 50mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: M881
Product name: Ropivacainemesylate
Packaging: 5g
Price: $298
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007267
Product name: ROPIVACAINE MESYLATE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

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Ropivacaine mesylate Chemical Properties,Usage,Production

Uses

Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of?sodium ion influx?in nerve fibressup>[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel)?TREK-1?with an IC50?of 402.7 μM in COS-7 cell's membrane[3].

in vivo

Epidural administration of Ropivacaine mesylate effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury^[1].
Ropivacaine mesylate inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC)^[2].
Ropivacaine mesylate prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats^[2].
Ropivacaine mesylate inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs^[2].

Animal Model:	Adult Sprague-Dawley rats (300-400g)^[2]
Dosage:	1 μM
Administration:	Infusion (added to the perfusate reservoir)
Result:	Attenuated pressure-dependent increases in filtration coefficient (K_f).

References

[1] Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321. DOI:10.1371/journal.pone.0117321
[2] Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28. DOI:10.1016/j.lfs.2019.02.053
[3] Dene Simpson, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717. DOI:10.2165/00003495-200565180-00013
[4] Hye Won Shin, et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth. 2014 Feb;28(1):81-6. DOI:10.1007/s00540-013-1661-1

Ropivacaine mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ropivacaine mesylate manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Ropivacaine mesylate 854056-07-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-21

Wuhan Biocar Pharmacy CO.,Ltd.

Product: Ropivacaine Mesylate 854056-07-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500KG
Release date: 2025-02-21

Wuhan Haorong Biotechnology Co.,Ltd

Product: Ropivacaine mesylate 854056-07-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500
Release date: 2023-07-14

854056-07-8, Ropivacaine mesylateRelated Search:

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ROPIVACAINE MESYLATE

(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate

Ropivacaine Mesylate API

Ropivacaine mesylate (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate

Ropivacaine Mesylate Injection

Ropivacaine mesylate USP/EP/BP

(S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamidemethanesulfonate

TIANFUCHEM--854056-07-8--Ropivacaine mesylate in stock

S-(-)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamidemethanesulfonate

854056-07-8

C17H26N2OCH4O3S

C17H26N2OCH3O3S

854056-07-8