GLYCINE ANHYDRIDE

Product Name: GLYCINE ANHYDRIDE
CAS No.: 106-57-0
Chemical Name: GLYCINE ANHYDRIDE
Synonyms: Oxiracetam-1;Cyclodiglycine;Glycinanhydrid;CYCLO(-GLY-GLY);GLYCINANHYDRIDE;ycine anhydride;Diglycolydiamide;Diketopiperazine;Glycerinanhydrid;Dioxo Piperazine
CBNumber: CB3356030
Molecular Formula: C4H6N2O2
Formula Weight: 114.1
MOL File: 106-57-0.mol

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GLYCINE ANHYDRIDE Property

Melting point:: >300 °C (lit.)
Boiling point:: 213.59°C (rough estimate)
Density: 1.3565 (rough estimate)
refractive index: 1.4487 (estimate)
storage temp.: Store below +30°C.
solubility: 142g/l
pka: 12.88±0.20(Predicted)
form: Crystalline Powder
color: White to slightly yellow
Water Solubility: Soluble in water (142mg/L).
Merck: 14,7466
BRN: 112112
InChIKey: BXRNXXXXHLBUKK-UHFFFAOYSA-N
CAS DataBase Reference: 106-57-0(CAS DataBase Reference)
EPA Substance Registry System: 2,5-Piperazinedione (106-57-0)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: TL6325250
TSCA: Yes
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G7251
Product name: Glycine anhydride
Purity: cyclic dipeptide
Packaging: 25g
Price: $80.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: G7251
Product name: Glycine anhydride
Purity: cyclic dipeptide
Packaging: 1kg
Price: $1040
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14160
Product name: 2,5-Piperazinedione
Purity: for synthesis
Packaging: 25G
Price: $147
Updated: 2024/03/01

TCI Chemical

Product number: G0100
Product name: Glycine Anhydride
Purity: >98.0%(N)
Packaging: 25g
Price: $94
Updated: 2024/03/01

TCI Chemical

Product number: G0100
Product name: Glycine Anhydride
Purity: >98.0%(N)
Packaging: 500g
Price: $746
Updated: 2024/03/01

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GLYCINE ANHYDRIDE Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellow crystalline powder

Uses

2,5-Piperazinedione, can be used as an intermediate in the preparation of various pharmaceutical and biologically active compounds. It can be used in the synthesis of dipeptide isosteres by cross-metathesis.

Definition

ChEBI: A cyclic peptide that is piperazine in which the hydrogens at positions 2 and 5 are replaced by oxo groups.

Synthesis Reference(s)

Journal of the American Chemical Society, 87, p. 4646, 1965 DOI: 10.1021/ja00948a047

Purification Methods

Recrystallise glycine anhydride from H2O (plates) and it can be sublimed (slowly) at 260o or at 140-170o/0.5mm. The dihydrochloride has m 129-130o and is prepared by dissolving it in conc HCl and adding EtOH to crystallisation point; dry it in a vacuum. The bis-1-naphthylurethane has m 232o(dec), and the diperchlorate has m 117o (hygroscopic). [MS: Johnstone J Chem Soc, Perkin Trans 1 1297 1975, NMR: Blaha & Samek Collect Czech Chem Commun 32 3780 1967, Sauborn J Phys Chem 36 179 1932, Corey J Am Chem Soc 60 1599 1938, Beilstein 24 IV 1070.]

GLYCINE ANHYDRIDE Preparation Products And Raw materials

Raw materials

Preparation Products

4-CHLORO-ALPHA-(METHYLAMINO)BENZENE ACETIC ACID

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GLYCINE ANHYDRIDE Suppliers

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View Lastest Price from GLYCINE ANHYDRIDE manufacturers

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Product: Glycine anhydride 106-57-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2 MTs
Release date: 2024-08-06

Career Henan Chemical Co

Product: GLYCINE ANHYDRIDE 106-57-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-24

106-57-0, GLYCINE ANHYDRIDERelated Search:

(S)-3-Isopropyl-2,5-piperazinedione CYCLO(-GLY-SER) CYCLO(-GLY-HIS) CYCLO(-GLY-TRP) cyclo(Gly-Ile) cyclo(Gly-Met) cyclo(Gly-Lys) cyclo(Gly-Arg) cyclo(Gly-Thr) cyclo(Gly-Asn) DL-2-AMINOPROPIONIC ANHYDRIDE GLYCINE ANHYDRIDE 1,4-DIACETYL-2,5-DIKETOPIPERAZINE 1,4-DIMETHYL-2,5-DIKETOPIPERAZINE,Sarcosine diketopiperazine VERRUCULOGEN AMPICILLIN IMP. C (EP):*) AMPICILLIN DIKETOPIPERAZINE MM(CRM STANDARD) Lisinopril R,S,S-Diketopiperazine GLYCINE ANHYDRIDE,2,5-DIKETOPIPERAZINE

PIPERAZINE-2,5-DIONE

Glycine EP Impurity B

Oxiracetam-1

2,5-Dioxopiperazin

2,5-Dioxopiperazine lactam

2,5-Piperazindion

alpha,gamma-Diacipiperazine

Cyclic(glycylglycyl)

Cyclo(glycylglycyl)

Cyclodiglycine

Diglycolydiamide

Diketopiperazine

Glycerinanhydrid

Glycinanhydrid

Glycine, bimol. cyclic peptide

2,5-PIPERAZINE-1,4-DIONE

2,5-Piperazinedione, Cyclo(-Gly-Gly)

2,5-Diketopiperazine, 2,5-Piperazinedione

α,γ-piperazinedione

Glycine anhydride,98%

2,5-Dioxopiperazine, Glycine anhydride

Glycine anhydride, 98% 100GR

Glycine anhydride, 98% 25GR

Glycine anhydride, 98% 5GR

oxiracetaM related substance ISF3890

2,5-Diketopiperazine 2,5-Dioxopiperazine Glycocoll Anhydride 2,5-Piperazinedione

2,5-Piperazinedione, Glycine anhydride, 2,5-Diketopiperazine

2,5-PIPERAZINEDIONE FOR SYNTHESIS

Glycine anhydride cyclic dipeptide

OxiracetaM IMp. ISF3890

Glycine Anhydride (2,5-Piperazinedione)

Oxiracetam impurity F

Glycine Impurity 2(Glycine EP Impurity B)

Oxiracetam impurity ISF3890 (glycine anhydride)

AMINOACETIC ACID ANHYDRIDE

A-G-DIACIPIPERAZINE

CYCLOGLYCYLGLYCINE

CYCLO(-GLY-GLY)

DIGLYCOLYLDIAMIDE

GLYCINANHYDRIDE

GLYCOCOLL ANHYDRIDE

GLYCINE ANHYDRIDE

GLYCYLGLYCINE LACTAM

2,5-DIKETOPIPERAZINE

2,5-DIOXOPIPERAZINE

2,5-PIPERAZINEDIONE

Dioxo Piperazine

Glycine, N-glycyl-, cyclic peptide

Glycylglycinelacton

GlycineAnhydride&gt

Oxiracetam Related Compound A

ycine anhydride

GLYCINE ANHYDRIDE USP/EP/BP

Piperazine-2,5-dione (Oxiracetam Impurity)

2,5-Piperazinodione

Busulfan Impurity1704

Oxiracetam impurities1716

Glycine Impurity B