TBTU

Product Name: TBTU
CAS No.: 125700-67-6
Chemical Name: TBTU
Synonyms: TBTU;2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE;TBPIPU;TBTU N;TBTU, 98%;TBTU 99.5%;KNORR REAGENT;TBTU extrapure;TBTU [ 125700-67-6;TBTU (Knorr reagent)
CBNumber: CB3357547
Molecular Formula: C11H16BF4N5O
Formula Weight: 321.09
MOL File: 125700-67-6.mol

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TBTU Property

Melting point:: 205 °C (dec.)(lit.)
storage temp.: 2-8°C
solubility: acetonitrile: 0.1 g/mL, clear
form: Powder
color: White to Almost white
Water Solubility: Soluble in acetonitrile (100 mg/ml, clear, colorless), DMF (160.55 mg/ml, clear), and water (3 mg/ml at 20°C).
Sensitive: Moisture Sensitive
BRN: 7066325
InChI: InChI=1S/C11H16N5O.BF4/c1-13(2)11(14(3)4)15-9-7-5-6-8-10(9)16(17)12-15;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1
InChIKey: NQGZJNPFMLJDKU-UHFFFAOYSA-M
SMILES: [B+3]([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=CC=CC=C/12)(\N(C)C)/N(C)C
LogP: -2.65 at 21℃
CAS DataBase Reference: 125700-67-6(CAS DataBase Reference)
EPA Substance Registry System: 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-) (1:1) (125700-67-6)

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Safety

Hazard Codes: Xi,F,E
Risk Statements: 36/37/38-5-2
Safety Statements: 26-36-37/39-36/37/39-35
RIDADR: 1325
WGK Germany: 3
F: 8-10-21
Hazard Note: Irritant/Flammable
HS Code: 2933 99 80
HazardClass: 4.1
PackingGroup: Ⅱ

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.51008
Product name: TBTU
Purity: 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem®
Packaging: 25 g
Price: $64.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51008
Product name: TBTU
Purity: 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem®
Packaging: 100 g
Price: $198
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51008
Product name: TBTU
Purity: 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem®
Packaging: 1 kg
Price: $444
Updated: 2025/07/31

Sigma-Aldrich

Product number: 12806
Product name: O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate
Purity: ≥97.0% (N)
Packaging: 5G
Price: $70.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 12806
Product name: O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate
Purity: ≥97.0% (N)
Packaging: 25g
Price: $193
Updated: 2025/07/31

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TBTU Chemical Properties,Usage,Production

Chemical Properties

TBTU [chemical name:2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate] is WHITE TO PALE CREAM FINE CRYSTALLINE POWDER

Uses

TBTU is a coupling reagent for peptide synthesis causing low racemization, which is ideally suited for solid-phase peptide synthesis. Also used in the synthesis of acid based t-antigen glycodendrimers.

reaction suitability

reaction type: Coupling Reactions

TBTU Preparation Products And Raw materials

Raw materials

Preparation Products

1-(PIPERIDIN-4-YLCARBONYL)PIPERIDINE

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TBTU Suppliers

Americas 1 Canada 3 China 442 Czech Republic 1 Europe 6 France 4 Germany 11 India 34 Israel 3 Japan 7 Poland 1 Slovakia 1 South Korea 1 Switzerland 7 The Netherlands 1 United Kingdom 21 United States 59 Global 603

Labex Corporation

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GLR Innovations

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TCI Chemicals (India) Pvt. Ltd.

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Sisco Research Laboratories Pvt. Ltd.

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Oceanic Pharmachem Pvt. Ltd.

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Keminntek Laboratories

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Molychem

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Santo Righello Pvt. Ltd

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Sisco Resech Laboratories Private Limited

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Anand Agencies

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HiMedia Laboratories

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VASIN BIO LIFE SCIENCES PVT LTD

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ASM Organics

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Sai Quest Syn. Ltd

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Spectrochem Private Limited

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Avra Synthesis Pvt Ltd

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LOBA CHEMIE PVT.LTD.

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Central Drug House(P) Ltd.

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CHEMSWORTH

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View Lastest Price from TBTU manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: TBTU 125700-67-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-12-02

Xinxiang Juyuan Biological Technology Co., Ltd.

Product: TBTU 125700-67-6
Price: US $700.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 50TONS
Release date: 2025-08-05

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate 125700-67-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-10

125700-67-6, TBTURelated Search:

Tolyltriazole AZURE B TETRAFLUOROBORATE 1,1,3,3-Tetramethylurea 1H-Benzotriazole 5-Methyl-1H-benzotriazole Ribavirin 1,2,3-1H-Triazole O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one 2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate HOAt 1-Hydroxybenzotriazole HBTU HATU Fluoroboric acid TBTU 1-Hydroxybenzotriazole hydrate

benzotriazol-1-yl-tetramethyluroniumtetrafluoroborate

[benzotriazol-1-yloxy(dimethylamino)methylene]-dimethyl-ammonium

1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Tetrafluoroborate

O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE

O-(1H-BENZOTRIAZOLE-1-YL) N,N,N',N'-TETRAMETHYL URONIUM TETRAFLUOROBORATE

O-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYL-URONIUM TETRAFLUOROBORATE

O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-PENTAMETHYLENE-URONIUM TETRAFLUOROBORATE

O-(1H-BENZO-1,2,3-TRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYL-URONIUM TETRAFLUOROBORATE

O-(BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE

N-[(1H-BENZOTRIAZOL-1-YL)(DIMETHYL-AMINO)METHYLENE]-N-METHYL-METHANAMINIUM TETRAFLUOROBORATE

TBPIPU

TBTU

TETRAFLUOROBORATE TBTU

O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRA- &

O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRAMETHY LURONIUM

TBTU,O-(BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE

O-Benzotriazol-lYL-N,N',N'-Tetramethyluronium Tetrafluoroborate

2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE (TBTU)

O-Benzotriazol-1-yl-N,N,N',N'-tetramethylisouronium tetrafluoroborate

TBTU/2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumtetrafluoroborate

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluro

2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetraMethyluroni

1H-BenzotriazoliuM-1-[bis(diMethylaMine)

2-(1H-Benzo[d][1,2,3]triazol-1-yl)-1,1,3,3-tetraMethyluroniuM tetrafluoroborate

TBTU, [(1H-Benzotriazol-1-yl)oxy](dimethylamino)-N,N-dimethylmethaniminium tetrafluoroborate

O-(BENZOTRIAZOLE-1-YL)-N,N,N',N'-TETRAMETHYL URONIUM TETRAFLUORO BORATE

KNORR REAGENT

2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE

2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE

O-(Benzotriazol-1-yl)-N,N,N',N'-tetraMethyluroniuM tetrafluoroborate >=97.0% (N)

3-[(dimethylamino)(dimethyliminiumyl)methyl]-1-oxo-2,3-dihydro-1H-1λ?,2,3-benzotriazol-1-ylium-2-ide

2-(1H-Benzotriazole-1-yl)-1,1,3,3-Tetram

TBTU (Knorr reagent)

O-(1H-BENZOTRIAZOL-1-YL)-N,N,N'',N''-TETRAMETHYLURONIUM TETRAFLUOROBORATE(TBTU)

O-Benzotriazol-l-yl- N,N,N'',N'',- tetramethyluroniumtetrafluoroborate

O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium Tetrafluoroborate (TBTU)

TDBTU (O-(3,4-DIHYDRO-4-OXO-1,2,3-BENZOTRIAZIN-3-YL)-N,N,N'',N''-TETRAMETHYLURONIUM TETRAFLUOROBORATE)

N-[(1H-Benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethanaminium tetrafluoroborate N-oxide

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate [Coupling Reagent for Peptide]

TBTU extrapure

benzotriazolyl tetramethyluronium fluoroborate

2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, 97+%

TBTU (o-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluo

benzotriazol-1-yl-N-tetramethyl-uronium tetrafluoroborate

O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluoroborate,97%

O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetraMethyluroniuM tetrafluoroborate, 99%, 99%

TBTU 99.5%

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate≥ 98% (HPLC)

N,N,N′,N′-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate

TBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem

O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate for synthesis

(Benzotriazol-1-yloxy-dimethylamino-methylene)dimethylammonium tetrafluoroborate

[dimethylamino-(3-oxidobenzotriazol-3-ium-1-yl)methylidene]-dimethylazanium

TBTU [Coupling Reagent for Peptide]

O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFL

TBTU, N,N,Nμ,Nμ-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate [Coupling Reagent for Peptide]&gt

TBTU N