1,1,3,3-Tetramethylurea
- Product Name
- 1,1,3,3-Tetramethylurea
- CAS No.
- 632-22-4
- Chemical Name
- 1,1,3,3-Tetramethylurea
- Synonyms
- TMU;TETRAMETHYLUREA;Urea, tetramethyl-;Temur;tetramethyl-ure;1,1,3,3-tetramethyl-ure;NSC 91488;((CH3)2N)2CO;TERAMETHYLUREA;Four Methylurea
- CBNumber
- CB1309805
- Molecular Formula
- C5H12N2O
- Formula Weight
- 116.16
- MOL File
- 632-22-4.mol
1,1,3,3-Tetramethylurea Property
- Melting point:
- −1 °C(lit.)
- Boiling point:
- 177 °C(lit.)
- Density
- 0.968 g/mL at 20 °C(lit.)
- refractive index
- n20/D 1.451(lit.)
- Flash point:
- 150 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Miscible with water, petroleum ether and common solvents.
- form
- Liquid
- pka
- 2.0(at 25℃)
- color
- Clear colorless to pale yellow
- PH
- 5-8 (25℃, 1M in H2O)
- Relative polarity
- 5
- Odor
- faint pleasant odor
- Water Solubility
- H2O: 1 M at 20 °C, miscible
- Merck
- 14,9230
- BRN
- 773898
- Dielectric constant
- 24.460000000000001
- InChIKey
- AVQQQNCBBIEMEU-UHFFFAOYSA-N
- CAS DataBase Reference
- 632-22-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Urea, tetramethyl-(632-22-4)
- EPA Substance Registry System
- Tetramethylurea (632-22-4)
Safety
- Hazard Codes
- Xn,T
- Risk Statements
- 22-61
- Safety Statements
- 53-45
- RIDADR
- NA 1993 / PGIII
- WGK Germany
- 3
- RTECS
- YU2625000
- F
- 3-10
- TSCA
- Yes
- HS Code
- 29241900
- Hazardous Substances Data
- 632-22-4(Hazardous Substances Data)
- Toxicity
- LD50 i.v. in rats: 1.1 g/kg (Lüttringhaus, Dirksen)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- T24503
- Product name
- Tetramethylurea
- Purity
- 99%
- Packaging
- 5g
- Price
- $29
- Updated
- 2024/03/01
- Product number
- T0158
- Product name
- Tetramethylurea
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $26
- Updated
- 2024/03/01
- Product number
- T0158
- Product name
- Tetramethylurea
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $191
- Updated
- 2024/03/01
- Product number
- A16295
- Product name
- Tetramethylurea
- Purity
- 99%
- Packaging
- 50g
- Price
- $42.8
- Updated
- 2024/03/01
- Product number
- A16295
- Product name
- Tetramethylurea
- Purity
- 99%
- Packaging
- 250g
- Price
- $147
- Updated
- 2024/03/01
1,1,3,3-Tetramethylurea Chemical Properties,Usage,Production
Chemical Properties
Tetramethylurea is a clear colorless to pale yellow liquid with mild aromatic odor that is miscible with water and many organic solvents. Unusual for an urea is the liquid state of tetramethylurea in a range of > 170 °C.
Uses
Tetramethylurea is used as a solvent in dyestuff industries, in condensation reaction and intermediates in surfactant. It is utilized for base catalyzed isomerization and alkylation hydrocyanation due to its low permittivity. It reacts with oxalyl chloride to prepare tetramethyl chloroformamidinium chloride, which is used for the conversion of carboxylic acids and dialkyl phosphates to anhydrides and pyrophosphates respectively.
Definition
ChEBI: 1,1,3,3-tetramethylurea is a member of the class of ureas that is urea substituted by methyl groups at positions 1, 1, 3 and 3 respectively. Metabolite observed in cancer metabolism. It has a role as a human metabolite.
Preparation
The reaction of dimethylamine with phosgene in the presence of e. g. 50 % sodium hydroxide solution and subsequent extraction with 1,2-dichloroethane yields tetramethylurea in 95% yield.
Safety Profile
Moderately toxic by ingestion and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. Combustible when exposed to heat, flame, and oxidizers. To fight fire, use foam, mist, spray, dry chemicals. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Dry it over BaO and distil it under nitrogen. It denatures proteins in H2O. [Elbaum & Herskovits Biochemistry 13 1268 1974, Kane Anal Biochem 53 350 1973, Beilstein 4 IV 225.]
1,1,3,3-Tetramethylurea Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,1,3,3-Tetramethylurea manufacturers
- Product
- 1,1,3,3-Tetramethylurea 632-22-4
- Price
- US $56.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 tons
- Release date
- 2023-04-03
- Product
- 1,1,3,3-Tetramethylurea 632-22-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-08-15
- Product
- 1,1,3,3-Tetramethylurea 632-22-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2023-01-04