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TBTU

Product Name
TBTU
CAS No.
125700-67-6
Chemical Name
TBTU
Synonyms
TBTU;2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE;TBPIPU;TBTU N;TBTU, 98%;TBTU 99.5%;KNORR REAGENT;TBTU extrapure;TBTU [ 125700-67-6;TBTU (Knorr reagent)
CBNumber
CB3357547
Molecular Formula
C11H16BF4N5O
Formula Weight
321.09
MOL File
125700-67-6.mol
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TBTU Property

Melting point:
205 °C (dec.)(lit.)
storage temp. 
2-8°C
solubility 
acetonitrile: 0.1 g/mL, clear
form 
Powder
color 
White to Almost white
Water Solubility 
Soluble in acetonitrile (100 mg/ml, clear, colorless), DMF (160.55 mg/ml, clear), and water (3 mg/ml at 20°C).
Sensitive 
Moisture Sensitive
BRN 
7066325
InChI
InChI=1S/C11H16N5O.BF4/c1-13(2)11(14(3)4)15-9-7-5-6-8-10(9)16(17)12-15;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1
InChIKey
NQGZJNPFMLJDKU-UHFFFAOYSA-M
SMILES
[B+3]([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=CC=CC=C/12)(\N(C)C)/N(C)C
LogP
-2.65 at 21℃
CAS DataBase Reference
125700-67-6(CAS DataBase Reference)
EPA Substance Registry System
1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-) (1:1) (125700-67-6)
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Safety

Hazard Codes 
Xi,F,E
Risk Statements 
36/37/38-5-2
Safety Statements 
26-36-37/39-36/37/39-35
RIDADR 
1325
WGK Germany 
3
F 
8-10-21
Hazard Note 
Irritant/Flammable
HS Code 
2933 99 80
HazardClass 
4.1
PackingGroup 
Ⅱ
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.51008
Product name
TBTU
Purity
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem<SUP>&#174;</SUP>
Packaging
25 g
Price
$64.3
Updated
2025/07/31
Sigma-Aldrich
Product number
8.51008
Product name
TBTU
Purity
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem<SUP>&#174;</SUP>
Packaging
100 g
Price
$198
Updated
2025/07/31
Sigma-Aldrich
Product number
8.51008
Product name
TBTU
Purity
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem<SUP>&#174;</SUP>
Packaging
1 kg
Price
$444
Updated
2025/07/31
Sigma-Aldrich
Product number
12806
Product name
O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate
Purity
≥97.0% (N)
Packaging
5G
Price
$70.3
Updated
2025/07/31
Sigma-Aldrich
Product number
12806
Product name
O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate
Purity
≥97.0% (N)
Packaging
25g
Price
$193
Updated
2025/07/31
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TBTU Chemical Properties,Usage,Production

Chemical Properties

TBTU [chemical name:2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate] is WHITE TO PALE CREAM FINE CRYSTALLINE POWDER

Uses

TBTU is a coupling reagent for peptide synthesis causing low racemization, which is ideally suited for solid-phase peptide synthesis. Also used in the synthesis of acid based t-antigen glycodendrimers.

reaction suitability

reaction type: Coupling Reactions

TBTU Preparation Products And Raw materials

Raw materials

Preparation Products

1-(PIPERIDIN-4-YLCARBONYL)PIPERIDINE
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TBTU Suppliers

Americas 1 Canada 3 China 442 Czech Republic 1 Europe 6 France 4 Germany 11 India 34 Israel 3 Japan 7 Poland 1 Slovakia 1 South Korea 1 Switzerland 7 The Netherlands 1 United Kingdom 21 United States 59 Global 603
Senn Chemicals AG.
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sales@sennchem.com
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Switzerland
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Matrix Fine Chemicals GmbH
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nfo@matrix-fine-chemicals.com
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Switzerland
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6968
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Bachem AG
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sales.ch@bachem.com
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Switzerland
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438
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SIGMA-RBI
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Switzerland
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6896
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AXXORA, LLC
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alexis-ch@alexis-corp.com
Country
Switzerland
ProdList
1104
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80
Alexis Corporation
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alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
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74
Senn Chemicals AG
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Email
swiss@sennchem.com
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Switzerland
ProdList
3143
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71
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View Lastest Price from TBTU manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
TBTU 125700-67-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KGS
Release date
2025-12-02
Xinxiang Juyuan Biological Technology Co., Ltd.
Product
TBTU 125700-67-6
Price
US $700.00/KG
Min. Order
1KG
Purity
99
Supply Ability
50TONS
Release date
2025-08-05
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate 125700-67-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-10

125700-67-6, TBTURelated Search:

Tolyltriazole AZURE B TETRAFLUOROBORATE 1,1,3,3-Tetramethylurea 1H-Benzotriazole 5-Methyl-1H-benzotriazole Ribavirin 1,2,3-1H-Triazole O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one 2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate HOAt 1-Hydroxybenzotriazole HBTU HATU Fluoroboric acid TBTU 1-Hydroxybenzotriazole hydrate

  • benzotriazol-1-yl-tetramethyluroniumtetrafluoroborate
  • [benzotriazol-1-yloxy(dimethylamino)methylene]-dimethyl-ammonium
  • 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Tetrafluoroborate
  • O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE
  • O-(1H-BENZOTRIAZOLE-1-YL) N,N,N',N'-TETRAMETHYL URONIUM TETRAFLUOROBORATE
  • O-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYL-URONIUM TETRAFLUOROBORATE
  • O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-PENTAMETHYLENE-URONIUM TETRAFLUOROBORATE
  • O-(1H-BENZO-1,2,3-TRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYL-URONIUM TETRAFLUOROBORATE
  • O-(BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE
  • N-[(1H-BENZOTRIAZOL-1-YL)(DIMETHYL-AMINO)METHYLENE]-N-METHYL-METHANAMINIUM TETRAFLUOROBORATE
  • TBPIPU
  • TBTU
  • TETRAFLUOROBORATE TBTU
  • O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRA- &
  • O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRAMETHY LURONIUM
  • TBTU,O-(BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE
  • O-Benzotriazol-lYL-N,N',N'-Tetramethyluronium Tetrafluoroborate
  • 2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE (TBTU)
  • O-Benzotriazol-1-yl-N,N,N',N'-tetramethylisouronium tetrafluoroborate
  • TBTU/2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumtetrafluoroborate
  • O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluro
  • 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetraMethyluroni
  • 1H-BenzotriazoliuM-1-[bis(diMethylaMine)
  • 2-(1H-Benzo[d][1,2,3]triazol-1-yl)-1,1,3,3-tetraMethyluroniuM tetrafluoroborate
  • TBTU, [(1H-Benzotriazol-1-yl)oxy](dimethylamino)-N,N-dimethylmethaniminium tetrafluoroborate
  • O-(BENZOTRIAZOLE-1-YL)-N,N,N',N'-TETRAMETHYL URONIUM TETRAFLUORO BORATE
  • KNORR REAGENT
  • 2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE
  • 2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE
  • O-(Benzotriazol-1-yl)-N,N,N',N'-tetraMethyluroniuM tetrafluoroborate >=97.0% (N)
  • 3-[(dimethylamino)(dimethyliminiumyl)methyl]-1-oxo-2,3-dihydro-1H-1λ?,2,3-benzotriazol-1-ylium-2-ide
  • 2-(1H-Benzotriazole-1-yl)-1,1,3,3-Tetram
  • TBTU (Knorr reagent)
  • O-(1H-BENZOTRIAZOL-1-YL)-N,N,N'',N''-TETRAMETHYLURONIUM TETRAFLUOROBORATE(TBTU)
  • O-Benzotriazol-l-yl- N,N,N'',N'',- tetramethyluroniumtetrafluoroborate
  • O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium Tetrafluoroborate (TBTU)
  • TDBTU (O-(3,4-DIHYDRO-4-OXO-1,2,3-BENZOTRIAZIN-3-YL)-N,N,N'',N''-TETRAMETHYLURONIUM TETRAFLUOROBORATE)
  • N-[(1H-Benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethanaminium tetrafluoroborate N-oxide
  • O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate [Coupling Reagent for Peptide]
  • TBTU extrapure
  • benzotriazolyl tetramethyluronium fluoroborate
  • 2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, 97+%
  • TBTU (o-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluo
  • benzotriazol-1-yl-N-tetramethyl-uronium tetrafluoroborate
  • O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluoroborate,97%
  • O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetraMethyluroniuM tetrafluoroborate, 99%, 99%
  • TBTU 99.5%
  • O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate≥ 98% (HPLC)
  • N,N,N′,N′-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate
  • TBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem
  • O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate for synthesis
  • (Benzotriazol-1-yloxy-dimethylamino-methylene)dimethylammonium tetrafluoroborate
  • [dimethylamino-(3-oxidobenzotriazol-3-ium-1-yl)methylidene]-dimethylazanium
  • TBTU [Coupling Reagent for Peptide]
  • O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFL
  • TBTU, N,N,Nμ,Nμ-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate
  • O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate [Coupling Reagent for Peptide]&gt
  • TBTU N