ChemicalBook > CAS DataBase List > 4-Bromophenylboronic acid

4-Bromophenylboronic acid

Product Name
4-Bromophenylboronic acid
CAS No.
5467-74-3
Chemical Name
4-Bromophenylboronic acid
Synonyms
4-bromophenylboric acid;4-BROMOBENZENEBORONIC ACID;p-BBBA;NSC 25407;AKOS BRN-0005;RARECHEM AH PB 0075;4-Bromophenylboronic;p-bromophenylboricacid;Flortaucipir Impurity 25;4-BROMOPHENYLBORONIC ACID
CBNumber
CB3361760
Molecular Formula
C6H6BBrO2
Formula Weight
200.83
MOL File
5467-74-3.mol
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4-Bromophenylboronic acid Property

Melting point:
284-288 °C (lit.)
Boiling point:
315.0±44.0 °C(Predicted)
Density 
1.67±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Crystalline Powder
pka
8.32±0.10(Predicted)
color 
Off-white to light beige
Water Solubility 
Soluble in methanol. Insoluble in water.
BRN 
2936347
InChI
InChI=1S/C6H6BBrO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H
InChIKey
QBLFZIBJXUQVRF-UHFFFAOYSA-N
SMILES
B(C1=CC=C(Br)C=C1)(O)O
CAS DataBase Reference
5467-74-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-22
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
CY8650000
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B75956
Product name
4-Bromophenylboronic acid
Purity
≥95.0%
Packaging
5g
Price
$88.2
Updated
2025/07/31
TCI Chemical
Product number
B1858
Product name
4-Bromophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
B1858
Product name
4-Bromophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$51
Updated
2025/07/31
TCI Chemical
Product number
B1858
Product name
4-Bromophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
25g
Price
$143
Updated
2025/07/31
TRC
Product number
B686545
Product name
4-Bromophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
100g
Price
$1075
Updated
2021/12/16
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4-Bromophenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

suzuki reaction

Uses

4-Bromobenzeneboronic acid is a reagent used for Palladium catalyzed Suzuki-Miyaura cross-couplings, Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence. It is also used in the preparation of Protein modulators and enzymatic and kinase inhibitors, Gallate-based obovatol analogs with potential anti-tumor activity. It is used as a reagent for Copper-mediated ligandless aerobic fluoroalkylation of arylboronic acids with fluoroalkyl iodides, Pd-catalyzed arylative cyclization of alkyne-tethered enals or enones via carbopalladation of alkynes, Copper-catalyzed cross-couplings.

Uses

Labelled 4-Bromophenylboronic Acid (B686545). 4-Bromophenylboric acid is used in the preparation of arylboronates as inhibitors of fatty acid amide hydrolase.

Synthesis

106-40-1

5467-74-3

GENERAL METHOD: 4-Bromoaniline (0.5 mmol, 1.0 eq.) was dissolved in methanol (1.0 mL), hydrochloric acid (0.5 mL, 1.5 mmol, 3.0 eq.) and water (0.5 mL) were added. The reaction mixture was stirred for 2 min and then sodium nitrite solution (0.25 mL, prepared by dissolving 35 mg of sodium nitrite in 0.25 mL of water) was added. Stir at 0-5 °C for 30 min, followed by the addition of hydrochloric acid (135 mg, 1.5 mmol, 3.0 equiv) in methanol (1.0 mL). Stirring was continued for 60 min. After completion of the reaction, it was diluted with water (10 mL) and extracted with dichloromethane (50 mL, 3 times). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 4-bromophenylboronic acid.

References

[1] Synlett, 2014, vol. 25, # 11, p. 1577 - 1584
[2] Chemistry - A European Journal, 2014, vol. 20, # 22, p. 6608 - 6612

4-Bromophenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Bromophenylboronic acid manufacturers

Shaanxi Didu New Materials Co. Ltd
Product
4-Bromophenylboronic acid 5467-74-3
Price
US $1.50/g
Min. Order
1g
Purity
99.0% Min
Supply Ability
10 Tons
Release date
2025-06-24
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-Bromophenylboronic acid 5467-74-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-25
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Bromophenylboronic acid 5467-74-3
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-21

5467-74-3, 4-Bromophenylboronic acidRelated Search:

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  • AKOS BRN-0005
  • 4-BROMOPHENYLBORIC ACID ANHYDRIDE
  • 4-BROMOPHENYLBORONIC ACID
  • 4-BROMOBENZENEBORONIC ACID
  • 4-BROMOBENZENEBORONIC ACID/ANHYDRIDE
  • RARECHEM AH PB 0075
  • P-BROMO BENZENE BORONIC ACID
  • P-BROMOPHENYLBORONIC ACID
  • (4-bromophenyl)-boronicaci
  • p-bromo-benzeneboronicaci
  • p-bromophenylboricacid
  • p-BBBA
  • NSC 25407
  • 4-Bromophenylboronic acid >=95.0%
  • Boronic acid,B-(4-bromophenyl)-
  • 4-Bromobenzeneboronic acid4-Bromobenzene
  • dihydroxy-4-bromophenylborane
  • 4-Bromobenzeneboronicacid,97+%
  • 4-Bromophenylboronic
  • Boronic acid, (4-bromophenyl)-
  • 4-bromophenylboric acid
  • 4-Bromobenzeneboronic acid4-Bromobenzeneboronic acid
  • (4-Bromophenyl)boranediol
  • (4-Bromophenyl)boranic acid
  • 4-Bromophenylboranic acid
  • 4-Bromophenylboron dihydoxide
  • 4-Bromophenylboronic acid,98%
  • 4-Bromophenylboronic Acid (contains varying amounts of Anhydride)
  • 4-Bromophenylboronic acid , May contain varying amounts of anhydride, 97%
  • Boronic acid, B-(4-bromopheny)-
  • 4-Bromophenylboronic Acid-d4 (contains varying amounts of Anhydride)
  • 5467-74-3 4-Bromophenylboronic acid
  • 4-Bromophenylboronic acid extrapure, 97%
  • Flortaucipir Impurity 25
  • 4-Bromophenylboronic acid, 97%
  • 4-Bromophenylboronic acid - [B1940]
  • (4-Bromopheny|)boronic acid
  • 5467-74-3
  • 5467-74-6
  • 5467-73-3
  • 5467-76-3
  • 5464-74-3
  • BrC6H4BOH2
  • BORONIC ACID
  • Boronic Acids
  • Aryl
  • Boronic Acids and Derivatives
  • B (Classes of Boron Compounds)
  • Organometallic Reagents
  • Boronate Ester
  • Potassium Trifluoroborate
  • OLED materials,pharm chemical,electronic
  • B (Classes of Boron Compounds)
  • Boronic acids
  • Boronic Acid
  • Aryl
  • Halogenated
  • Organoborons