ChemicalBook > CAS DataBase List > Cbz-Cyclohexyl-L-glycine

Cbz-Cyclohexyl-L-glycine

Product Name
Cbz-Cyclohexyl-L-glycine
CAS No.
69901-75-3
Chemical Name
Cbz-Cyclohexyl-L-glycine
Synonyms
Z-CHG-OH;Cbz-CycL;CBZ-CHG-OH;Z-L-Chg-OH;Cbz-L-CHG-OH;Z-CYCLOHEXYL-GLY-OH;Z-Cyclohexylglycine;Z-PHG(HEXAHYDRO)-OH;Z-L-CYCLOHEXYLGLYCINE;Z-L-cyclohexyl-Gly-OH
CBNumber
CB3362020
Molecular Formula
C16H21NO4
Formula Weight
291.35
MOL File
69901-75-3.mol
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Cbz-Cyclohexyl-L-glycine Property

Melting point:
111-114°C
Boiling point:
492.1±38.0 °C(Predicted)
Density 
1.200±0.06 g/cm3(Predicted)
vapor pressure 
0Pa at 25℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.99±0.10(Predicted)
color 
White
InChI
InChI=1/C16H21NO4/c18-15(19)14(13-9-5-2-6-10-13)17-16(20)21-11-12-7-3-1-4-8-12/h1,3-4,7-8,13-14H,2,5-6,9-11H2,(H,17,20)(H,18,19)/t14-/s3
InChIKey
CUSYTUPJAYLNFQ-WDHUHKLTNA-N
SMILES
[C@H](C1CCCCC1)(C(=O)O)NC(=O)OCC1C=CC=CC=1 |&1:0,r|
LogP
1.7 at 25℃ and pH2.5
CAS DataBase Reference
69901-75-3(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological
Product number
242739
Product name
Z-L-2-cyclohexylglycine
Packaging
1g
Price
$193
Updated
2021/12/16
TRC
Product number
C227500
Product name
Cbz-Cyclohexyl-L-glycine
Packaging
50g
Price
$435
Updated
2021/12/16
Activate Scientific
Product number
AS35511
Product name
(S)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid
Purity
97+% ee
Packaging
5G
Price
$32
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC19841
Product name
Cbz-cyclohexyl-L-glycine
Packaging
10g
Price
$40
Updated
2021/12/16
Chem-Impex
Product number
12222
Product name
Z-L-2-cyclohexylglycine,98%(HPLC)
Purity
98%(HPLC)
Packaging
1G
Price
$40.54
Updated
2021/12/16
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Cbz-Cyclohexyl-L-glycine Chemical Properties,Usage,Production

Chemical Properties

Cbz-Cyclohexyl-L-glycine is white to Off-White Solid

Uses

Cbz-Cyclohexyl-L-glycine is a gylicine derivative used in the preparation of peptides as inhibitors of serine proteases, particularly hepatitis C virus NS3-NS4A protease.

Synthesis

14328-51-9

501-53-1

69901-75-3

General Steps: Step (1): 534 mL of deionized water and 60.9 mL of 20% aqueous sodium hydroxide were added to 60.0 g of L-(+)-2-cyclohexylglycine (L-CHG) and stirred until completely dissolved. Subsequently, activated carbon was added to the solution for decolorization and supplemented with 79 mL of deionized water. Under stirring, 65.1 g of benzyl chloroformate (Cbz-Cl) and 60.9 mL of 20% aqueous sodium hydroxide solution were added slowly and dropwise to introduce a benzyloxycarbonyl (Cbz) protecting group in the L-CHG molecule. Step (2): the reaction solution obtained in step (1) (total volume 865 mL) was added to deionized water and isopropyl alcohol (IPA) in the proportions shown in Table 1, respectively. Step (3): After the completion of step (2), 4.1 mL of hydrochloric acid was added to the reaction solution to carry out the neutralization reaction, and the precipitated crystals were subsequently separated by filtration. The crystals obtained by filtration were dried to finally obtain (S)-2-(((benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid (Cbz-L-CHG). The specific results for each experimental condition are detailed in Table 1.

References

[1] Patent: US2011/152573, 2011, A1. Location in patent: Page/Page column 3

Cbz-Cyclohexyl-L-glycine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cbz-Cyclohexyl-L-glycine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cbz-Cyclohexyl-L-glycine 69901-75-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-08-28
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Cbz-Chg-OH 69901-75-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-05
Hangzhou ICH Biofarm Co., Ltd
Product
Cbz-Cyclohexyl-L-glycine 69901-75-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
97%
Supply Ability
100kg
Release date
2023-06-30

69901-75-3, Cbz-Cyclohexyl-L-glycineRelated Search:

N-Carbobenzyloxyglycine Trimethoprim Isocyanatocyclohexane Benzyloxyacetyl chloride Stearic acid Folic acid Ethyl 2-(Chlorosulfonyl)acetate Molasses Glycine Cyclohexylbenzene Betaine Benzyl glycinate hydrochloride Cyclohexanemethanol Z-3-CYCLOHEXYL-L-ALANINE Citric acid Ascoric Acid N-Cbz-L-Isoleucine Z-NLE-OH

  • Cyclohexaneacetic acid,a-[[(phenylMethoxy)carbonyl]aMino]-,(aS)-
  • Cbz-L-CHG-OH
  • CBZ-CHG-OH
  • N-Benzyloxycarbonyl-L-2-cyclohexylglycine, 95%
  • (S)-N-Cbz-Aminocyclohexylacetic acid
  • Cbz-Cyclohexyl-L-glycine
  • Z-Cyclohexylglycine
  • (S)-α-[[(phenylMethoxy)carbonyl]aMino]cyclohexaneacetic Acid
  • (αS)-α-[[(PhenylMethoxy)carbonyl]aMino]cyclohexaneacetic Acid
  • Z-CHG-OH
  • Z-CYCLOHEXYL-GLY-OH
  • Z-L-2-CYCLOHEXYLGLYCINE
  • Z-L-CYCLOHEXYLGLYCINE
  • Z-PHG(HEXAHYDRO)-OH
  • (S)-CBZ-CYCLOHEXYLGLYCINE
  • N-ALPHA-CARBOBENZOXY-L-CYCLOHEXYLGLYCINE
  • N-ALPHA-CARBOBENZOXY-HEXAHYDRO-L-PHENYLGLYCINE
  • CBZ-L-CYCLOHEXYLGLYCINE
  • (S)-2-(benzyloxycarbonylamino)-2-cyclohexylacetic acid
  • (2S)-2-{[(benzyloxy)carbonyl]amino}-2-cyclohexylacetic acid
  • N-Cbz-alpha-cyclohexyl-L-glycine
  • Z-L-Chg-OH
  • Z-L-cyclohexyl-Gly-OH
  • Cyclohexaneacetic acid, α-[[(phenylmethoxy)carbonyl]amino]-, (αS)-
  • Cbz-cyclohexyl-L-glycine (terprovir intermediate)
  • 2-cyclohexyl-3-oxo-3-phenylmethoxypropanoic acid
  • Cbz-CycL
  • (S)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylaceticaci
  • (S)-2-cyclohexyl-2-((ethoxycarbonyl)amino)acetic acid
  • Cbz-Cyclohexyl-L-glycine USP/EP/BP
  • 69901-75-3 Cbz-Cyclohexyl-L-glycine
  • N-Benzyloxycarbonyl-L-2- cyclohexylgl
  • (2S)-[[(benzyloxy)carbonyl]amino](cyclohexyl)acetic acid
  • 69901-75-3
  • CARBOXYLIC ACID
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  • Aromatics
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  • chiral
  • Chiral Reagent