ChemicalBook > CAS DataBase List > tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester

Product Name
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
CAS No.
3392-12-9
Chemical Name
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
Synonyms
2,5-Dioxopyrrolidin-1-yl (tert-butoxycarbonyl)-L-valinate;BOC-VAL-OSU;BOC-L-VALINE HYDROXYSUCCINIMIDE ESTER;(S)-2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)-3-methylbutanoate;￥545,287.00;Boc-Val-ONSu;BOC-VALINE-OSU;Boc-L-Val-ONSu;Boc-Val-succinimide;Boc-Val-OSu >=98.5% (N)
CBNumber
CB3363294
Molecular Formula
C14H22N2O6
Formula Weight
314.33
MOL File
3392-12-9.mol
More
Less

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Property

Melting point:
126-128 °C
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
-20°C
pka
10.72±0.46(Predicted)
form 
Powder
color 
White to off-white
optical activity
[α]20/D 38±1°, c = 2% in dioxane
Sensitive 
Moisture Sensitive
BRN 
1551859
CAS DataBase Reference
3392-12-9(CAS DataBase Reference)
More
Less

Safety

WGK Germany 
3
F 
3-10-21
HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15531
Product name
Boc-Val-OSu
Purity
≥98.5% (N)
Packaging
5g
Price
$75.6
Updated
2025/07/31
Usbiological
Product number
264806
Product name
Boc-L-valine N-hydroxysuccinimide ester
Packaging
25g
Price
$366
Updated
2021/12/16
Chem-Impex
Product number
03675
Product name
Boc-L-valineN-hydroxysuccinimideester,98%(HPLC)
Purity
98%(HPLC)
Packaging
5G
Price
$21.28
Updated
2021/12/16
Activate Scientific
Product number
AS43220
Product name
(S)-2,5-Dioxopyrrolidin-1-yl 2-((Boc)amino)-3-methylbutanoate
Purity
95% ee
Packaging
5G
Price
$32
Updated
2021/12/16
Chem-Impex
Product number
03675
Product name
Boc-L-valine -hydroxysuccinimide ester
Purity
≥ 99% (HPLC)
Packaging
25G
Price
$56.9
Updated
2021/12/16
More
Less

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

6066-82-6

13734-41-3

3392-12-9

Step A: Boc-L-valine (1.03 g, 4.74 mmol), N-hydroxysuccinimide (1.22 g, 10.6 mmol), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 1.60 g, 8.35 mmol) were sequentially added to a dry round-bottom flask. The above reagents were dissolved in anhydrous dichloromethane (30 mL), and the reaction system was sealed through a rubber septum and displaced three times with argon to exclude oxygen. Subsequently, the reaction mixture was stirred at room temperature.After 3 days, thin layer chromatography (TLC) detection (ninhydrin color development) confirmed that the Boc-L-valine was fully reacted. The reaction solution was washed sequentially with water, saturated aqueous sodium bicarbonate, and the aqueous phase was back-extracted with dichloromethane. The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and dried under vacuum to obtain white solid Boc-L-valine hydroxysuccinimide ester (1.52 g, 100% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 4.98 (broad peak, 1H), 4.58 (double peak, 1H), 2.82 (multiple peaks, 4H), 2.27 (multiple peaks, 1H), 1.44 (single peak, 9H), 1.03 (double peaks, 6H).

References

[1] Patent: WO2016/160615, 2016, A1. Location in patent: Paragraph 0444; 0445
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 14, p. 2461 - 2480
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2852 - 2857
[4] Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984, p. 2305 - 2308
[5] Journal of Organic Chemistry, 1986, vol. 51, # 24, p. 4580 - 4585

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Suppliers

China 106 Germany 3 Hungary 1 India 1 Japan 2 Switzerland 3 United Kingdom 5 United States 21 Global 142
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Tianjin Chempharmatech Co.,Ltd.
Tel
022-66211079 13212288319
Fax
qq1405432731
Email
sales@chempharmatech.com
Country
China
ProdList
918
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Sicemo Ltd.
Tel
0532-85625977 13668866880
Email
interchem@foxmail.com
Country
China
ProdList
74
Advantage
55
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7991
Advantage
55
Shanghai GL Peptide Ltd.
Tel
+86-21-61263340; 17609490614 13764994101
Fax
021-61263399
Email
fisherwang@glschina.com
Country
China
ProdList
8258
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Wuxi Asia Peptide Biotechnology Limited Company
Tel
0510-83583050 13771062561
Fax
0510-83583039
Email
willsun@peptide-search.com
Country
China
ProdList
6716
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Sichuan jiayinglai technology CO.,LTD
Tel
028-028-88457210 18190964009
Fax
QQ3213375147
Email
3054240163@qq.com
Country
China
ProdList
2293
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Nanijing m&m biotechnology Co. ,Ltd.
Tel
025-87782433 18021532344
Fax
025-87782433
Email
1345332203@qq.com
Country
China
ProdList
4135
Advantage
58
Shanghai BaiShun Biological Technology Co., Ltd
Tel
021-37581181
Fax
021-57456066
Email
sales@chem-mall.com
Country
China
ProdList
10330
Advantage
58
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15083
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Jinan Kabotang Biological Technology Co.,Ltd.
Tel
0531-61320525 15866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
5177
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai Moss Medicine Technology Co., Ltd.
Tel
+86-188369842 +86-15618151133
Fax
QQ188369842
Email
188369842@qq.com
Country
China
ProdList
1959
Advantage
58
Kanghua (Shanghai) New Drug Development Co., Ltd.
Tel
021-61263370 18901917034
Email
xingli@glbiochem.com
Country
China
ProdList
5637
Advantage
58
Shanghai Jifeng Biotechnology Co., Ltd.
Tel
021-61263377 15023907684
Fax
021-61263399
Email
15800684150@163.com
Country
China
ProdList
8131
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
Finetech Industry Limited
Tel
+86-27-8746-5837 +8619945049750
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
ProdList
9629
Advantage
58
GL Biochem (Shanghai) Ltd.
Tel
+86-021-61263370 +86-18901917034
Country
CHINA
ProdList
3904
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
20284
Advantage
58
GL Biochem(Binhai) Ltd.
Tel
+86-021-61263370 +8615301650015
Email
wuqiuyan@glschina.com
Country
China
ProdList
2975
Advantage
58
More
Less

View Lastest Price from tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
tert-Butoxycarbonyl-L-valine 3392-12-9
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-19
Career Henan Chemical Co
Product
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester 3392-12-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2018-08-15
Career Henan Chemical Co
Product
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester 3392-12-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15

3392-12-9, tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide esterRelated Search:

PYRAZOPHOS 1,1'-Carbonyldiimidazole O-Phthalimide Dibutyl phthalate Dimethyl succinate L-Valine Methyl acrylate Cyhalofop-butyl Butyl acetate Maleimide Bismaleimide Valine CARBONYL SULFIDE tert-Butanol Tris(trimethylsilyl)phosphate BUTYL OLEATE Succinimide Diethylene glycol monobutyl ether

  • BOC-L-VALINE HYDROXYSUCCINIMIDE ESTER
  • BOC-L-VALINE N-HYDROXYSUCCINIMIDE ESTER
  • BOC-VAL-OSU
  • BOC-VALINE-OSU
  • N-ALPHA-T-BOC-L-VALINE N-HYDROXYSUCCINIMIDE ESTER
  • N-BOC-L-VAL-N-HYDROXYSUCCINIMIDE
  • N-TERT-BUTOXYCARBONYL-L-VALINE-N-HYDROXYSUCCINIMIDE ESTER
  • tert-butyl (S)-[1-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]-2-methylpropyl]carbamate
  • BOC-L-VALINE HYDROXYSUCCINIMIDESTER
  • N-(tert-butoxycarbonyl)-L-valine hydroxysuccinimide ester
  • tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
  • [(S)-1-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester
  • Boc-L-Val-ONSu
  • N-(tert-Butoxycarbonyl)-L-valine succinimidyl ester
  • (S)-2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)-3-methylbutanoate
  • L-Valine, N-[(1,1-diMethylethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester
  • Boc-Val-OSu >=98.5% (N)
  • ￥545,287.00
  • Boc-Val-ONSu
  • Boc-Val-succinimide
  • Boc-L-valineN-hydroxysuccinimide ester≥ 99% (HPLC)
  • N-Boc-L-valine N-succinimidyl ester
  • (Tert-Butoxy)Carbonyl Val-Osu
  • (2,5-Dioxopyrrolidin-1-yl) (2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoate
  • (2,5-dioxopyrrolidin-1-yl)(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate
  • tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester USP/EP/BP
  • 2,5-Dioxopyrrolidin-1-yl (tert-butoxycarbonyl)-L-valinate
  • tert-Butoxycarbonyl-L-valine
  • 3392-12-9
  • 545-28-7
  • 545287
  • C14H22N2O6
  • Amino Acid Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • Valine
  • Amino Acid Derivatives
  • Amino Acid