ChemicalBook > CAS DataBase List > tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester

Product Name
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
CAS No.
3392-12-9
Chemical Name
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
Synonyms
2,5-Dioxopyrrolidin-1-yl (tert-butoxycarbonyl)-L-valinate;BOC-VAL-OSU;BOC-L-VALINE HYDROXYSUCCINIMIDE ESTER;(S)-2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)-3-methylbutanoate;￥545,287.00;Boc-Val-ONSu;BOC-VALINE-OSU;Boc-L-Val-ONSu;Boc-Val-succinimide;Boc-Val-OSu >=98.5% (N)
CBNumber
CB3363294
Molecular Formula
C14H22N2O6
Formula Weight
314.33
MOL File
3392-12-9.mol
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tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Property

Melting point:
126-128 °C
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
-20°C
pka
10.72±0.46(Predicted)
form 
Powder
color 
White to off-white
optical activity
[α]20/D 38±1°, c = 2% in dioxane
Sensitive 
Moisture Sensitive
BRN 
1551859
CAS DataBase Reference
3392-12-9(CAS DataBase Reference)
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Safety

WGK Germany 
3
F 
3-10-21
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15531
Product name
Boc-Val-OSu
Purity
≥98.5% (N)
Packaging
5g
Price
$75.6
Updated
2025/07/31
Usbiological
Product number
264806
Product name
Boc-L-valine N-hydroxysuccinimide ester
Packaging
25g
Price
$366
Updated
2021/12/16
Iris Biotech GmbH
Product number
BAA6040
Product name
Boc-L-Val-OSu
Packaging
100g
Price
$371.25
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB47750
Product name
Boc-L-valine N-hydroxysuccinimide ester
Packaging
250g
Price
$430
Updated
2021/12/16
Chem-Impex
Product number
03675
Product name
Boc-L-valineN-hydroxysuccinimideester,98%(HPLC)
Purity
98%(HPLC)
Packaging
250G
Price
$526.68
Updated
2021/12/16
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tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

6066-82-6

13734-41-3

3392-12-9

Step A: Boc-L-valine (1.03 g, 4.74 mmol), N-hydroxysuccinimide (1.22 g, 10.6 mmol), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 1.60 g, 8.35 mmol) were sequentially added to a dry round-bottom flask. The above reagents were dissolved in anhydrous dichloromethane (30 mL), and the reaction system was sealed through a rubber septum and displaced three times with argon to exclude oxygen. Subsequently, the reaction mixture was stirred at room temperature.After 3 days, thin layer chromatography (TLC) detection (ninhydrin color development) confirmed that the Boc-L-valine was fully reacted. The reaction solution was washed sequentially with water, saturated aqueous sodium bicarbonate, and the aqueous phase was back-extracted with dichloromethane. The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and dried under vacuum to obtain white solid Boc-L-valine hydroxysuccinimide ester (1.52 g, 100% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 4.98 (broad peak, 1H), 4.58 (double peak, 1H), 2.82 (multiple peaks, 4H), 2.27 (multiple peaks, 1H), 1.44 (single peak, 9H), 1.03 (double peaks, 6H).

References

[1] Patent: WO2016/160615, 2016, A1. Location in patent: Paragraph 0444; 0445
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 14, p. 2461 - 2480
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2852 - 2857
[4] Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984, p. 2305 - 2308
[5] Journal of Organic Chemistry, 1986, vol. 51, # 24, p. 4580 - 4585

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
tert-Butoxycarbonyl-L-valine 3392-12-9
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-19
Career Henan Chemical Co
Product
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester 3392-12-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2018-08-15
Career Henan Chemical Co
Product
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester 3392-12-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15

3392-12-9, tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide esterRelated Search:

PYRAZOPHOS 1,1'-Carbonyldiimidazole O-Phthalimide Dibutyl phthalate Dimethyl succinate L-Valine Methyl acrylate Cyhalofop-butyl Butyl acetate Maleimide Bismaleimide Valine CARBONYL SULFIDE tert-Butanol Tris(trimethylsilyl)phosphate BUTYL OLEATE Succinimide Diethylene glycol monobutyl ether

  • BOC-L-VALINE HYDROXYSUCCINIMIDE ESTER
  • BOC-L-VALINE N-HYDROXYSUCCINIMIDE ESTER
  • BOC-VAL-OSU
  • BOC-VALINE-OSU
  • N-ALPHA-T-BOC-L-VALINE N-HYDROXYSUCCINIMIDE ESTER
  • N-BOC-L-VAL-N-HYDROXYSUCCINIMIDE
  • N-TERT-BUTOXYCARBONYL-L-VALINE-N-HYDROXYSUCCINIMIDE ESTER
  • tert-butyl (S)-[1-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]-2-methylpropyl]carbamate
  • BOC-L-VALINE HYDROXYSUCCINIMIDESTER
  • N-(tert-butoxycarbonyl)-L-valine hydroxysuccinimide ester
  • tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
  • [(S)-1-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester
  • Boc-L-Val-ONSu
  • N-(tert-Butoxycarbonyl)-L-valine succinimidyl ester
  • (S)-2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)-3-methylbutanoate
  • L-Valine, N-[(1,1-diMethylethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester
  • Boc-Val-OSu >=98.5% (N)
  • ￥545,287.00
  • Boc-Val-ONSu
  • Boc-Val-succinimide
  • Boc-L-valineN-hydroxysuccinimide ester≥ 99% (HPLC)
  • N-Boc-L-valine N-succinimidyl ester
  • (Tert-Butoxy)Carbonyl Val-Osu
  • (2,5-Dioxopyrrolidin-1-yl) (2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoate
  • (2,5-dioxopyrrolidin-1-yl)(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate
  • tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester USP/EP/BP
  • 2,5-Dioxopyrrolidin-1-yl (tert-butoxycarbonyl)-L-valinate
  • tert-Butoxycarbonyl-L-valine
  • 3392-12-9
  • 545-28-7
  • 545287
  • C14H22N2O6
  • Amino Acid Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • Valine
  • Amino Acid Derivatives
  • Amino Acid