tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
- Product Name
- tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
- CAS No.
- 3392-12-9
- Chemical Name
- tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
- Synonyms
- 2,5-Dioxopyrrolidin-1-yl (tert-butoxycarbonyl)-L-valinate;BOC-VAL-OSU;BOC-L-VALINE HYDROXYSUCCINIMIDE ESTER;(S)-2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)-3-methylbutanoate;￥545,287.00;Boc-Val-ONSu;BOC-VALINE-OSU;Boc-L-Val-ONSu;Boc-Val-succinimide;Boc-Val-OSu >=98.5% (N)
- CBNumber
- CB3363294
- Molecular Formula
- C14H22N2O6
- Formula Weight
- 314.33
- MOL File
- 3392-12-9.mol
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Property
- Melting point:
- 126-128 °C
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- pka
- 10.72±0.46(Predicted)
- form
- Powder
- color
- White to off-white
- optical activity
- [α]20/D 38±1°, c = 2% in dioxane
- Sensitive
- Moisture Sensitive
- BRN
- 1551859
- CAS DataBase Reference
- 3392-12-9(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- F
- 3-10-21
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 15531
- Product name
- Boc-Val-OSu
- Purity
- ≥98.5% (N)
- Packaging
- 5g
- Price
- $75.6
- Updated
- 2025/07/31
- Product number
- 264806
- Product name
- Boc-L-valine N-hydroxysuccinimide ester
- Packaging
- 25g
- Price
- $366
- Updated
- 2021/12/16
- Product number
- BAA6040
- Product name
- Boc-L-Val-OSu
- Packaging
- 100g
- Price
- $371.25
- Updated
- 2021/12/16
- Product number
- FB47750
- Product name
- Boc-L-valine N-hydroxysuccinimide ester
- Packaging
- 250g
- Price
- $430
- Updated
- 2021/12/16
- Product number
- 03675
- Product name
- Boc-L-valineN-hydroxysuccinimideester,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 250G
- Price
- $526.68
- Updated
- 2021/12/16
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
peptide synthesis
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
6066-82-6
13734-41-3
3392-12-9
Step A: Boc-L-valine (1.03 g, 4.74 mmol), N-hydroxysuccinimide (1.22 g, 10.6 mmol), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 1.60 g, 8.35 mmol) were sequentially added to a dry round-bottom flask. The above reagents were dissolved in anhydrous dichloromethane (30 mL), and the reaction system was sealed through a rubber septum and displaced three times with argon to exclude oxygen. Subsequently, the reaction mixture was stirred at room temperature.After 3 days, thin layer chromatography (TLC) detection (ninhydrin color development) confirmed that the Boc-L-valine was fully reacted. The reaction solution was washed sequentially with water, saturated aqueous sodium bicarbonate, and the aqueous phase was back-extracted with dichloromethane. The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and dried under vacuum to obtain white solid Boc-L-valine hydroxysuccinimide ester (1.52 g, 100% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 4.98 (broad peak, 1H), 4.58 (double peak, 1H), 2.82 (multiple peaks, 4H), 2.27 (multiple peaks, 1H), 1.44 (single peak, 9H), 1.03 (double peaks, 6H).
References
[1] Patent: WO2016/160615, 2016, A1. Location in patent: Paragraph 0444; 0445
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 14, p. 2461 - 2480
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2852 - 2857
[4] Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984, p. 2305 - 2308
[5] Journal of Organic Chemistry, 1986, vol. 51, # 24, p. 4580 - 4585
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Suppliers
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View Lastest Price from tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester manufacturers
- Product
- tert-Butoxycarbonyl-L-valine 3392-12-9
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-19
- Product
- tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester 3392-12-9
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-15
- Product
- tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester 3392-12-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-15