2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
- Product Name
- 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
- CAS No.
- 209256-42-8
- Chemical Name
- 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
- Synonyms
- Tasimelteon INT;Tasimelteon intermediate;2,3-DIHYDRO-BENZOFURAN-4-CARBALDEHYDE;2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE;2,3-dihydro-1-benzofuran-4-carbaldehyde;4-Benzofurancarboxaldehyde, 2,3-dihydro-;4-Benzofurancarboxaldehyde, 2,3-dihydro- (9CI)
- CBNumber
- CB3368204
- Molecular Formula
- C9H8O2
- Formula Weight
- 148.16
- MOL File
- 209256-42-8.mol
2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Property
- Boiling point:
- 276℃
- Density
- 1.222
- Flash point:
- 132℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D446965
- Product name
- 2,3-Dihydrobenzofuran-4-carbaldehyde
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 0701AB
- Product name
- 2,3-Dihydrobenzofuran-4-carbaldehyde
- Packaging
- 250mg
- Price
- $143
- Updated
- 2021/12/16
- Product number
- FD139110
- Product name
- 2,3-Dihydro-4-benzofurancarboxaldehyde
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FD139110
- Product name
- 2,3-Dihydro-4-benzofurancarboxaldehyde
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 0701AB
- Product name
- 2,3-Dihydrobenzofuran-4-carbaldehyde
- Packaging
- 100mg
- Price
- $126
- Updated
- 2021/12/16
2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Chemical Properties,Usage,Production
Uses
2,3-Dihydrobenzofuran-4-carbaldehyde is used in the synthesis of macroline derivatives as inhibitors of mycobacterium tuberculosis protein tyrosine phosphatase B.
Synthesis
209256-41-7
209256-42-8
The general procedure for the synthesis of 2,3-dihydrobenzofuran-4-carbaldehyde from 4-hydroxymethyl-benzodihydrofuran was as follows: a dichloromethane solution (40 mL, 2 M) of oxalyl chloride was stirred at -78 °C and DMSO (8.10 mL, 114 mmol) was slowly added. Subsequently, a dichloromethane solution (35 mL) of 4-hydroxymethyl-benzodihydrofuran (8.53 g, 56.9 mmol) was added dropwise and stirring was continued for 30 min at -78 °C. Upon completion of the reaction, triethylamine (33 mL, 228 mmol) was carefully added to quench the reaction. The resulting suspension was stirred at room temperature for 30 min and then diluted with dichloromethane (100 mL). The organic layer was washed three times with water and twice with brine sequentially, and finally concentrated by vacuum to give 2,3-dihydrobenzofuran-4-carbaldehyde as an oil (8.42 g, 100%), which could be used for subsequent reactions without further purification.
References
[1] Patent: EP1041980, 2005, B1. Location in patent: Page 17
[2] Patent: EP1027043, 2004, B1. Location in patent: Page/Page column 17
2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE manufacturers
- Product
- Tasimelteon INT 209256-42-8
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 95%
- Supply Ability
- Inquiry
- Release date
- 2023-03-30
- Product
- 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE 209256-42-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02