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Hexamethylene bisacetamide

Product Name
Hexamethylene bisacetamide
CAS No.
3073-59-4
Chemical Name
Hexamethylene bisacetamide
Synonyms
NSC-95580;N,N′1,6-DIACETAMIDOHEXANE;1,6-Hexanebisacetamide;Hexamethylenediacetamide;hexamethylenebisacetamide;HEXAMETHYLENE BISCETAMIDE;Hexamethylene bisacetamide;N,N'-Diacetyl-1,6-hexadiamine;N-(6-acetamidohexyl)acetamide
CBNumber
CB3374289
Molecular Formula
C10H20N2O2
Formula Weight
200.28
MOL File
3073-59-4.mol
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Hexamethylene bisacetamide Property

Melting point:
128-129 °C(lit.)
Boiling point:
338.01°C (rough estimate)
Density 
0.974
refractive index 
1.4710 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
water: soluble5%, clear, colorless
form 
A solid
pka
16.20±0.46(Predicted)
BRN 
1775764
InChI
InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14)
InChIKey
BNQSTAOJRULKNX-UHFFFAOYSA-N
SMILES
C(NC(=O)C)CCCCCNC(=O)C
CAS DataBase Reference
3073-59-4(CAS DataBase Reference)
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Safety

Risk Statements 
33
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
AC2976200
HS Code 
29241990
Toxicity
human,TDLo,intravenous,4270mg/kg/10D (4270mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBLOOD: THROMBOCYTOPENIA,Cancer Research. Vol. 47, Pg. 5788, 1987.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
224235
Product name
N,N′-Hexamethylene bis(acetamide)
Purity
98%
Packaging
10g
Price
$32.4
Updated
2023/01/07
Sigma-Aldrich
Product number
224235
Product name
N,N′-Hexamethylene bis(acetamide)
Purity
98%
Packaging
50g
Price
$120
Updated
2023/01/07
Alfa Aesar
Product number
B22771
Product name
N,N'-Diacetyl-1,6-diaminohexane
Purity
96%
Packaging
250g
Price
$194
Updated
2021/12/16
Alfa Aesar
Product number
B22771
Product name
N,N'-Diacetyl-1,6-diaminohexane, 96%
Packaging
50g
Price
$49.7
Updated
2021/12/16
TRC
Product number
H296705
Product name
HexamethyleneBiscetamide
Packaging
25g
Price
$45
Updated
2021/12/16
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Hexamethylene bisacetamide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder or flakes

Uses

N,N′-Hexamethylene bis(acetamide) was used as an inducing agent in obtaining mononuclear cells from the peripheral blood (PB) sample by Ficoll-Hypaque gradient separation.

Definition

ChEBI: N-(6-acetamidohexyl)acetamide is a member of acetamides.

Biological Activity

Hexamethylene bisacetamide is a tumor cell-differentiating agent. It induces complete differentiation of 754A murine erythroleukemia cells when used at a concentration of 5 mM. Hexamethylene bisacetamide also induces latent HIV-1 viral production in chronically HIV-1-infected U1 cells in a concentration-dependent manner. Implantation of HT-29 colon cancer cells cultured with hexamethylene bisacetamide for seven days, but not 28, reduces tumorigenesis of those cells in mice. Hexamethylene Bisacetamide (HMBA) is a hybrid polar compound originally developed as a differentiation-inducing agent. HMBA can inhibit the activation of several NF kappaB target genes in both lung and breast cancer cell lines. Furthermore, consistent with its ability to inhibit NF kappaB function, HMBA can also sensitize cells to apoptosis. HMBA mediates inhibition of the Akt and ERK/MAPK cascade, both critical for cell survival and proliferation and are well-known regulators of NF kappaB activation[1].

References

[1] Anwesha Dey. “Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy.” Cell Cycle 7 23 (2008): 3759–67.

Hexamethylene bisacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Hexamethylene bisacetamide Suppliers

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View Lastest Price from Hexamethylene bisacetamide manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
N,N'-DIACETYL-1,6-DIAMINOHEXANE 3073-59-4
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-18

3073-59-4, Hexamethylene bisacetamideRelated Search:

NYLON 6/10 N,N'-DIACETYL-1,6-DIAMINOHEXANE BIOTIN HPDP N,N'-HEXAMETHYLENEBISACRYLAMIDE Nylon 6/6 Antioxidant 1098 1,6-HEXAMETHYLENE BIS-METHACRYLAMIDE N-Biotinyl-N'-(iodoacetyl)-1,6-hexanediaMine NPC-15437 DIHYDROCHLORIDE 1,6-BISMALEIMIDOHEXANE Chaetocin NYLON 6/12 HEXAMETHYLENE POLYADIPAMIDE 1-[4-AZIDOSALICYLAMIDO]-6-[BIOTINAMIDO]-HEXANE 1,1''-([4,4'-BIPIPERIDINE]-1,1'-DIYLDICARBONYL)BIS[1'-(METHOXYCARBONYL) FERROCENE] AMCA-HPDP NYLON 6/9

  • Acetamide, N,N'-1,6-hexanediylbis-
  • N,N'-HEXAMETHYLENEBISACETAMIDE
  • N,N'-DIACETYL-1,6-DIAMINOHEXANE
  • N,N'-DIACETYL-1,6-HEXANEDIAMINE
  • 1,6-Hexanebisacetamide
  • N,N'-(Hexane-1,6-diyl)diacetaMide
  • N,N'-Diacetyl-1,6-diaminohexane, 98+%
  • N,N'-Diacetyl-1,6-hexadiamine
  • N,Nμ-Diacetyl-1,6-hexanediamine, HMBA
  • N,N'-Hexamethylenebisacetamide,98%
  • N-(6-acetamidohexyl)acetamide
  • Acetamide, N,N'-hexamethylenebis-
  • Hexamethylene bisacetamide
  • hexamethylenebisacetamide
  • Hexamethylenediacetamide
  • n,n’-1,6-hexanediylbis-acetamid
  • n,n’-1,6-hexanediylbisacetamide
  • n,n’-diacetylhexamethylenediamine
  • n,n’-hexamethylenebis-acetamid
  • N,N'-Diacetylhexamethylenediamine
  • N-[6-(Acetylamino)hexyl]acetamide
  • NSC-95580
  • 1,6-DIACETAMIDOHEXANE
  • HEXAMETHYLENE BISCETAMIDE
  • Inhibitor,Hexamethylene bisacetamide,HMBA,inhibit
  • N,N'-Diacetyl-1,6-diarninohexane
  • N,N'-DIACETYL-1,6-DIAMINOHEXANE
  • N,N'-(Hexane-1,6-diyl)diacetamide
  • <I>N,N&#8242
  • 3073-59-4
  • C4H14O2N2
  • CH3CONHCH26NHCOCH3
  • Nitrogen Compounds
  • Organic Building Blocks
  • Protected Amines
  • Building Blocks