Hexamethylene bisacetamide
- Product Name
- Hexamethylene bisacetamide
- CAS No.
- 3073-59-4
- Chemical Name
- Hexamethylene bisacetamide
- Synonyms
- NSC-95580;N,N′1,6-DIACETAMIDOHEXANE;1,6-Hexanebisacetamide;Hexamethylenediacetamide;hexamethylenebisacetamide;HEXAMETHYLENE BISCETAMIDE;Hexamethylene bisacetamide;N,N'-Diacetyl-1,6-hexadiamine;N-(6-acetamidohexyl)acetamide
- CBNumber
- CB3374289
- Molecular Formula
- C10H20N2O2
- Formula Weight
- 200.28
- MOL File
- 3073-59-4.mol
Hexamethylene bisacetamide Property
- Melting point:
- 128-129 °C(lit.)
- Boiling point:
- 338.01°C (rough estimate)
- Density
- 0.974
- refractive index
- 1.4710 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- water: soluble5%, clear, colorless
- form
- A solid
- pka
- 16.20±0.46(Predicted)
- BRN
- 1775764
- InChI
- InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14)
- InChIKey
- BNQSTAOJRULKNX-UHFFFAOYSA-N
- SMILES
- C(NC(=O)C)CCCCCNC(=O)C
- CAS DataBase Reference
- 3073-59-4(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- 224235
- Product name
- N,N′-Hexamethylene bis(acetamide)
- Purity
- 98%
- Packaging
- 10g
- Price
- $32.4
- Updated
- 2023/01/07
- Product number
- 224235
- Product name
- N,N′-Hexamethylene bis(acetamide)
- Purity
- 98%
- Packaging
- 50g
- Price
- $120
- Updated
- 2023/01/07
- Product number
- B22771
- Product name
- N,N'-Diacetyl-1,6-diaminohexane
- Purity
- 96%
- Packaging
- 250g
- Price
- $194
- Updated
- 2021/12/16
- Product number
- B22771
- Product name
- N,N'-Diacetyl-1,6-diaminohexane, 96%
- Packaging
- 50g
- Price
- $49.7
- Updated
- 2021/12/16
- Product number
- H296705
- Product name
- HexamethyleneBiscetamide
- Packaging
- 25g
- Price
- $45
- Updated
- 2021/12/16
Hexamethylene bisacetamide Chemical Properties,Usage,Production
Chemical Properties
white crystalline powder or flakes
Uses
N,N′-Hexamethylene bis(acetamide) was used as an inducing agent in obtaining mononuclear cells from the peripheral blood (PB) sample by Ficoll-Hypaque gradient separation.
Definition
ChEBI: N-(6-acetamidohexyl)acetamide is a member of acetamides.
Biological Activity
Hexamethylene bisacetamide is a tumor cell-differentiating agent. It induces complete differentiation of 754A murine erythroleukemia cells when used at a concentration of 5 mM. Hexamethylene bisacetamide also induces latent HIV-1 viral production in chronically HIV-1-infected U1 cells in a concentration-dependent manner. Implantation of HT-29 colon cancer cells cultured with hexamethylene bisacetamide for seven days, but not 28, reduces tumorigenesis of those cells in mice. Hexamethylene Bisacetamide (HMBA) is a hybrid polar compound originally developed as a differentiation-inducing agent. HMBA can inhibit the activation of several NF kappaB target genes in both lung and breast cancer cell lines. Furthermore, consistent with its ability to inhibit NF kappaB function, HMBA can also sensitize cells to apoptosis. HMBA mediates inhibition of the Akt and ERK/MAPK cascade, both critical for cell survival and proliferation and are well-known regulators of NF kappaB activation[1].
References
[1] Anwesha Dey. “Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy.” Cell Cycle 7 23 (2008): 3759–67.
Hexamethylene bisacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
Hexamethylene bisacetamide Suppliers
- Tel
- --
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- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from Hexamethylene bisacetamide manufacturers
- Product
- N,N'-DIACETYL-1,6-DIAMINOHEXANE 3073-59-4
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-18