BOC-L-Asparagine

Product Name: BOC-L-Asparagine
CAS No.: 7536-55-2
Chemical Name: BOC-L-Asparagine
Synonyms: BOC-ASN;NαBOC-L-ASN;BOC-ASN-OH;15381_FLUKA;-Boc-Nω-Boc-N-βBOC-L-ASN-OH;Nα-BOC-L-Asn;-Fmoc-N-&beta
CBNumber: CB3375413
Molecular Formula: C9H16N2O5
Formula Weight: 232.23
MOL File: 7536-55-2.mol

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BOC-L-Asparagine Property

Melting point:: 175 °C (dec.)(lit.)
Boiling point:: 374.39°C (rough estimate)
Density: 1.2896 (rough estimate)
refractive index: -7 ° (C=1, DMF)
Flash point:: 245°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: almost transparency in N,N-DMF
form: Powder or Crystalline Powder
pka: 3.79±0.10(Predicted)
color: White
optical activity: [α]20/D 7.8±0.5°, c = 2% in DMF
BRN: 1977963
InChI: InChI=1S/C9H16N2O5/c1-9(2,3)16-8(15)11-5(7(13)14)4-6(10)12/h5H,4H2,1-3H3,(H2,10,12)(H,11,15)(H,13,14)/t5-/m0/s1
InChIKey: FYYSQDHBALBGHX-YFKPBYRVSA-N
SMILES: C(O)(=O)[C@H](CC(N)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference: 7536-55-2(CAS DataBase Reference)
EPA Substance Registry System: L-Asparagine, N2-[(1,1-dimethylethoxy)carbonyl]- (7536-55-2)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
TSCA: Yes
HS Code: 2924 19 00
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53039
Product name: Boc-Asn-OH
Purity: Novabiochem?
Packaging: 25g
Price: $52.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53039
Product name: Boc-Asn-OH
Purity: Novabiochem?
Packaging: 100g
Price: $433
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15381
Product name: Boc-Asn-OH
Purity: ≥98.5% (T)
Packaging: 25g
Price: $73.3
Updated: 2025/07/31

TCI Chemical

Product number: B1627
Product name: Nalpha-(tert-Butoxycarbonyl)-L-asparagine
Purity: >98.0%(HPLC)(T)
Packaging: 10g
Price: $23
Updated: 2025/07/31

TRC

Product number: B622005
Product name: Nα-Boc-L-asparagine
Packaging: 25g
Price: $55
Updated: 2021/12/16

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BOC-L-Asparagine Chemical Properties,Usage,Production

Chemical Properties

WHITE AMORPHOUS POWDER

Uses

Nα-Boc-L-asparagine is an N-Boc-protected form of L-Asparagine (A790005). L-Asparagine was first isolated by Robiquet and Vauquelin from asparagus juice (a high source of L-asparagine). L-Asparagine is often incorporated into proteins, and is a basis for some cancer therapies as certain cancerous cells require L-asparagine for growth.

Definition

ChEBI: The Nalpha-t-butoxycarbonyl derivative of L-asparagine

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

70-47-3

24424-99-5

7536-55-2

L-asparagine (15 g, 0.113 mol, 1.0 eq.) and sodium carbonate (12 g, 0.113 mol, 1.0 eq.) were dissolved in a solvent mixture of water (225 mL) and 1,4-dioxane (225 mL) at room temperature. To this solution was slowly added di-tert-butyl dicarbonate (30 g, 0.137 mol, 1.2 eq.) and the reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, 1,4-dioxane was removed by distillation under reduced pressure. Subsequently, the pH of the solution was adjusted to 2 with 37% hydrochloric acid, at which point a white solid precipitated. The solid product was collected by filtration, washed with water and dried under appropriate conditions. Finally, 24 g of BOC-L-asparagine was obtained in 91% yield. The product characterization data were as follows: melting point 175°C-180°C (literature value 175°C); 1H NMR (DMSO-D6) δ 12.5 (1H, br); 7.31 (1H, br); 6.91 (1H, br); 6.87 (1H, d, J=8.4 Hz); 4.23 (1H, q, J=7.7 Hz); 2.56- 2.36 (2H, m); 1.38 (9H, s).

References

[1] Patent: WO2005/21558, 2005, A2. Location in patent: Page/Page column 214
[2] Patent: US2006/189806, 2006, A1. Location in patent: Page/Page column 38
[3] Bioorganic and Medicinal Chemistry, 1998, vol. 6, # 8, p. 1185 - 1208
[4] Angewandte Chemie - International Edition, 2007, vol. 46, # 14, p. 2470 - 2477
[5] Organic Syntheses, 1985, vol. 63, p. 160 - 160

BOC-L-Asparagine Preparation Products And Raw materials

Raw materials

L-Asparagine

Preparation Products

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BOC-L-Asparagine Suppliers

Americas 1 China 308 Europe 4 France 2 Germany 6 Hungary 1 India 24 Italy 2 Japan 8 Switzerland 5 United Kingdom 12 United States 56 Global 429

Anhui Dexinjia Biopharm Co., Ltd

Tel: 0531-82375892 15553111391
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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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future industrial shanghai co., ltd

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Email: sales@jonln.com
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Alfa Aesar

Tel: 400-6106006
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TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
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Email: Sales-CN@TCIchemicals.com
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ProdList: 24529
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ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
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View Lastest Price from BOC-L-Asparagine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Asn-OH 7536-55-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-20

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Boc-L-Asn-OH 7536-55-2
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-02

Anhui Dexinjia Biopharm Co., Ltd

Product: BOC-L-Asparagine 7536-55-2
Price: US $15.00-50.00/kg
Min. Order: 1kg
Purity: NLT98%
Supply Ability: 5 ton per month
Release date: 2024-07-09

7536-55-2, BOC-L-AsparagineRelated Search:

L-Asparagine ASPARAGINASE D-(-)-Asparagine monohydrate Di-tert-butyl dicarbonate PYRAZOPHOS 2-Chloro-2-methylpropane 1,1'-Carbonyldiimidazole FMOC-ASN(TRT)-OPFP DI-TERT-BUTYL ETHER Carbonyl iron powder NICKEL CARBONYL N-BOC-L-ASPARAGINE(XANTHYL) BOC-L-ASPARAGINE(TRITYL) BOC-ASP-OH NALPHA-BOC-D-ASPARAGINE,N-ALPHA-T-BOC-D-ASPARAGINE,BOC-D-ASPARAGINE,N-BOC-D-ASPARAGINE,NA-T-BOC-D-ASPARAGINE DDZ-ASN-OH BOC-L-ASPARAGINE BENZYL ESTER BOC-L-ASPARAGINE N-HYDROXYSUCCINIMIDE ESTER

T-BUTYLOXYCARBONYL-L-ASPARAGINE

TBOC-L-ASPARAGINE

N-TERT-BUTOXYCARBONYL-L-ASPARAGINE

N-T-BUTOXYCARBONYL-L-ASPARAGINE

N-T-BOC-L-ASPARAGINE

N2-[(1,1-Dimethylethoxy)carbonyl]-L-asparagine

NALPHA-BOC-L-ASPARAGINE

N-ALPHA-T-BOC-L-ASPARAGINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-ASPARAGINE

N-(ALPHA)-TERT-BUTOXYCARBONYL-L-ASPARAGINE

N-ALPHA-T-BUTOXYCARBONYL-L-ASPARAGINE

N-BOC-L-ASPARAGINE

-Boc-N&omega

-Boc-L-Ornithine Tert-butyl Ester Hydrochloride

-Dimethyl-1,4-cyclohexadiene-1-ethanamine

-Boc-N-&beta

-bromoacetyl-L-2,3-diaminopropionic Acid

-Methylphenethyl)-gluconamide

-(4-Methylphenyl)sulfonyl)benzyl]diphenylphosphinic Amide

-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic Acid

-Fmoc-N-&beta

n2-[(1,1-dimethylethoxy)carbonyl]-l-asparagin

BOC-ASN-OH

BOC-ASN

BOC-ASPARAGINE

BOC-L-ASN

BOC-L-ASPARAGINE

BOC-L-ASN-OH

BOC-L-ASPARAGINE-OH

N-(a)-Boc-L-asparagine

NA-T-BOC-L-ASPARAGINE

N(ALPHA)-BOC-L-ASPARAGINE 99+%

N-BOC-L-ASN-OH

N-(-tert-Butoxycarbonyl-L-asparagine, 98+%

(S)-4-aMino-2-((tert-butoxycarbonyl)aMino)-4-oxobutanoic acid

L-2-tert-ButoxycarbonylaMino-succinaMicacid

-(Tert-Butoxycarbonyl)-L-Asparagine

N&alpha

N<SUB>α</SUB>-(tert-Butoxycarbonyl)-L-asparagine

N2-[(tert-butoxy)carbonyl]-L-asparagine

Boc-L-aspaD23-Ragine

Boc-Asn-OH >=98.5% (T)

(2S)-4-amino-2-(tert-butoxycarbonylamino)-4-keto-butyric acid

(2S)-4-amino-2-(tert-butoxycarbonylamino)-4-oxo-butanoic acid

(2S)-4-amino-2-[(tert-butoxy-oxomethyl)amino]-4-oxobutanoic acid

15381_FLUKA

EINECS 231-405-2

(Tert-Butoxy)Carbonyl Asn-OH

Boc-(S)-2-aminosuccinic acid 4-amide monohydrate

Nα-Boc-L-asparagine≥ 98.5% (HPLC)

-Dimethyl-3-pyridineethanamine

-Benzoyl-DL-arginine &beta

-Naphthylamide Hydrochloride

-Bis(ethoxycarbonylethyl)-L-lysine Methyl Ester

Boc-Asn-OH, BR

-Diethylphenethylamine Hydrochloride

-Boc-L-arginine Hydrochloride

-Diethylphenethylamine-d5 Hydrochloride