ChemicalBook > CAS DataBase List > Boc-3-(2-Naphthyl)-L-alanine

Boc-3-(2-Naphthyl)-L-alanine

Product Name
Boc-3-(2-Naphthyl)-L-alanine
CAS No.
58438-04-3
Chemical Name
Boc-3-(2-Naphthyl)-L-alanine
Synonyms
BOC-2-NAL-OH;BOC-NAL(2)-OH;BOC-L-2-NAL-OH;BOC-D-BETA-NAL-OH;BOC-ALA(2-NAPH)-OH;RARECHEM BK PT 0098;BOC-ALA(2-NAPHTHYL)-OH;BOC-2-L-NAPHTHYLALANINE;BOC-(2-naphthyl)alanine;BOC-L-2-NAPHTHYLALANINE
CBNumber
CB3375448
Molecular Formula
C18H21NO4
Formula Weight
315.36
MOL File
58438-04-3.mol
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Boc-3-(2-Naphthyl)-L-alanine Property

Melting point:
92-95 °C(lit.)
Boiling point:
454.92°C (rough estimate)
Density 
1.2164 (rough estimate)
refractive index 
1.5740 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Ethanol
form 
Solid
pka
3.88±0.30(Predicted)
color 
Off-white
optical activity
[α]20/D +45±2°, c = 1% in ethanol
BRN 
4326467
CAS DataBase Reference
58438-04-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Safety Statements 
22-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15483
Product name
Boc-2-Nal-OH
Purity
≥97.0% (HPLC)
Packaging
1g
Price
$103
Updated
2025/07/31
TCI Chemical
Product number
B3617
Product name
N-(tert-Butoxycarbonyl)-3-(2-naphthyl)-L-alanine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$98
Updated
2025/07/31
TRC
Product number
B657985
Product name
N-Boc-3-(2-naphthyl)-L-alanine
Packaging
25g
Price
$385
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB47420
Product name
Boc-3-(2-naphthyl)-L-alanine
Packaging
25g
Price
$536
Updated
2021/12/16
Chem-Impex
Product number
02586
Product name
Boc-3-(2-naphthyl)-L-alanine,99.5%(ChiralHPLC)
Purity
99.5%(ChiralHPLC)
Packaging
25G
Price
$548.8
Updated
2021/12/16
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Boc-3-(2-Naphthyl)-L-alanine Chemical Properties,Usage,Production

Chemical Properties

beige to light brown powder

Uses

N-Boc-3-(2-naphthyl)-L-alanine Functions as a reagent for the synthesis of dipeptidyl nitriles as potent and reversible inhibitors of Cathepsin C

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

6960-34-5

74651-77-7

56583-58-5

The general procedure for the synthesis of 2-((tert-butoxycarbonyl)amino)-3-(naphthalen-2-yl)propanoic acid from the compound (CAS: 6960-34-5) and (E)-N-((tert-butoxycarbonyl)oxy)benzylidene cyanocyanide was as follows: 1. N-Butoxycarbonyl-L-3-(2-naphthalenyl)alanine (0.43 g, 2.0 mmol) was dissolved in a solvent mixture of dioxane (8 mL), water (8 mL) and triethylamine (4 mL). 2. BOC-ON (0.49 g, 2.0 mmol) was added and the reaction mixture was stirred overnight at room temperature under argon protection. 3. Upon completion of the reaction, the mixture was diluted with water (30 mL) and extracted with ethyl acetate (3 x 20 mL). 4. The aqueous layer was acidified to pH=4 with 10% citric acid solution and extracted with ethyl acetate (3 x 20 mL). 5. The organic phases were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give a colorless oily product (0.52 g, 82% yield). 6. The product was characterized by 1H NMR (DMSO-d6): δ 7.8 (3H, m), 7.7 (1H, s), 7.4 (3H, m), 7.15 (1H, d), 4.2 (1H, m), 3.2 (1H, m), 2.9 (1H, m), 1.3 (9H, s).

References

[1] Patent: US5486597, 1996, A

Boc-3-(2-Naphthyl)-L-alanine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-3-(2-Naphthyl)-L-alanine Suppliers

Americas 1 Belgium 1 China 164 Europe 2 Germany 6 India 3 Japan 4 Switzerland 5 United Kingdom 9 United States 48 Global 243
Gaolai (Shanghai) Pharmaceutical Technology Co., Ltd.
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18862951601
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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Shanghai HC Biotech Co., Ltd
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021-20227858
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+86-21-20227857
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Alfa Aesar
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021-67582001/03/05
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Sichuan Tongsheng Amino acids Co.,Ltd.
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TCI (Shanghai) Development Co., Ltd.
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Energy Chemical
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021-58436166
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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86-027-87531808
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sales@chemwish.com
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GL Biochem (Shanghai) Ltd
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21-61263452 13641803416
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86-21-61263399
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ymbetter@glbiochem.com
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View Lastest Price from Boc-3-(2-Naphthyl)-L-alanine manufacturers

Career Henan Chemical Co
Product
Boc-3-(2-Naphthyl)-L-alanine 58438-04-3
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

58438-04-3, Boc-3-(2-Naphthyl)-L-alanineRelated Search:

Phenprobamate N-Carbobenzyloxyglycine D-Alanine EC 2.6.1.2 L-Alanine 1-(1-NAPHTHYL)-2-THIOUREA tert-Butanol Boc-3-(2-Naphthyl)-D-alanine BOC-BETA-(1-NAPHTHYL)-L-ALANINE,N-ALPHA-T-BOC-BETA-(1-NAPHTHYL)-L-ALANINE,BOC-3-(1-NAPHTHYL)-L-ALANINE BOC-3-(1-NAPHTHYL)-D-ALANINE,BOC-BETA-(1-NAPHTHYL)-D-ALANINE,N-ALPHA-T-BOC-BETA-(1-NAPHTHYL)-D-ALANINE (R)-3-(Boc-amino)-3-(2-naphthyl)propionic acid, L-Boc-3-(2-naphthyl)-β-alanine 3-(2-Naphthyl)-L-alanine 3-(2-NAPHTHYL)-L-ALANINE HYDROCHLORIDE BOC-3-(2-NAPHTHYL)-L-ALANINE MERRIFIELD RESIN D-BOC-3-(2-NAPHTHYL)-BETA-ALANINE BOC-3-(1-PYRENYL)-L-ALANINE L-Alanine BOC-(S)-ALPHA-(2-NAPHTHALENYLMETHYL)-PROLINE

  • BOC-ALA(2-NAPH)-OH
  • BOC-ALA(2-NAPHTHYL)-OH
  • BOC-ALA-BETA-(2-NAPHTHYL)-OH
  • BOC-2-NAL-OH
  • BOC-2-L-NAPHTHYLALANINE
  • BOC-3-(2-NAPHTHYL)-ALANINE
  • BOC-(2-naphthyl)alanine
  • (S)-N-Boc-2-naphthylalanine, 95%, ee:98%
  • (S)-N-BOC-2-Naphthylalanine,95%,98% ee
  • 2-Naphthalenepropanoicacid, a-[[(1,1-diMethylethoxy)carbonyl]aMi
  • N-Boc-3-(2-naphthyl)-L-alanine (S)-alpha-tert-Butoxycarbonylamino-2-naphthalenepropionic Acid (S)-alpha-(Boc-amino)-2-naphthalenepropionic Acid
  • (2S)-2-[(tert-butoxycarbonyl)aMino]-3-(2-naphthyl)propanoic acid
  • Boc-3-(2-naphthyl)-L-alanine, Boc-Ala(2-naphthyl)-OH
  • Boc-3-(2-naphthyl)-L-alanine99%
  • Boc-L-Ala(2-naphthyl)-OH
  • (Tert-Butoxy)Carbonyl 2-Nal-OH
  • BOC-3-(2-NAPHTHYL)-L-ALANINE
  • N-BOC-3-(2-NAPHTHYL)-L-ALANINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-3-(2-NAPHTHYL)-ALANINE
  • N-ALPHA-(TERT-BUTYLOXYCARBONYL)-3-(2-NAPHTHYL)-L-ALANINE
  • N-ALPHA-T-BOC-BETA-(2-NAPHTHYL)-L-ALANINE
  • N-ALPHA-T-BUTOXYCARBONYL-3-(2-NAPHTHYL)-L-ALANINE
  • N-(TERT-BUTOXYCARBONYL)-3-(2-NAPHTHYL)-L-ALANINE
  • N-TERT-BUTOXYCARBONYL-2-NAPHTHYL-L-ALANINE
  • (S)-N-BOC-2-NAPHTHYLALANINE
  • RARECHEM BK PT 0098
  • (S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(NAPHTHALEN-2-YL)PROPANOIC ACID
  • (S)-2-TERT-BUTOXYCARBONYLAMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID
  • N-T-BOC-L-3-(2-NAPHTHYL)ALANINE
  • N-(TERT-BUTOXYCARBONYL)-3-(2-NAPHTHYL)-&
  • (S)-BOC-3-(2-NAPHTHYL)-L-ALANINE
  • N-alpha-tert-Butoxycarbonyl-3-(2-naphthyl)-L-alanin
  • (S)-N-BOC-2-Naphthylalanine, 98% ee, 95%
  • N-ALPHA-(T-BUTYLOXYCARBONYL)-3-(2-NAPHTHYL)-L-ALANINE
  • 3-Naphth-2-yl-L-alanine, N-BOC protected
  • BOC-D-BETA-NAL-OH
  • BOC-L-3-(2-NAPHTYL)-ALANINE
  • BOC-NAL(2)-OH
  • BOC-L-2-NAL-OH
  • BOC-L-2-NAPHTHYLALANINE
  • BOC-L-3-(2-NAPHTHYL)-ALANINE
  • BOC-BETA-(2-NAPHTHYL)-L-ALANINE
  • (2S)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-3-(2-naphthalenyl)propanoic acid
  • N-(tert-Butoxycarbonyl)-3-(2-naphthyl)-L-alanine &gt
  • 2-Naphthalenepropanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αS)-
  • (S)-alpha-(Boc-amino)-2-naphthalenepropionic Acid
  • (S)-alpha-tert-Butoxycarbonylamino-2-naphthalenepropionic Acid
  • Boc-3-(2-Naphthyl)-L-alanine USP/EP/BP
  • Boc-3-3(Naphthyl)-L-Alanine
  • Boc-3-(2-Naphthyl)-L-Ala
  • 58438-04-3
  • C18H221NO4
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • Alanine Derivatives
  • a-amino
  • Alanine [Ala, A]