4-Formyl-2-methylthiazole
- Product Name
- 4-Formyl-2-methylthiazole
- CAS No.
- 20949-84-2
- Chemical Name
- 4-Formyl-2-methylthiazole
- Synonyms
- IFLAB-BB F2124-0689;4-FORMYL-2-METHYLTHIAZOLE;2-Methyl-4-forMylthiazole;4-Formyl-2-methyl-1,3-thiazole;2-Methyl-4-thiazolecarbaldehyde;2-Methylthiazole-4-carboxaldehyde;2-Methyl-4-thiazolecarboxaldehyde;4-THIAZOLECARBOXALDEHYDE, 2-METHYL-;2-METHYL-1,3-THIAZOLE-4-CARBALDEHYDE;2-Methyl-1,3-thiazole-4-carboxaldehyde
- CBNumber
- CB3378469
- Molecular Formula
- C5H5NOS
- Formula Weight
- 127.16
- MOL File
- 20949-84-2.mol
4-Formyl-2-methylthiazole Property
- Melting point:
- 56-58
- Boiling point:
- 219.0±13.0 °C(Predicted)
- Density
- 1.270±0.06 g/cm3(Predicted)
- Flash point:
- 110℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 1.22±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C5H5NOS/c1-4-6-5(2-7)3-8-4/h2-3H,1H3
- InChIKey
- AEHWVNPVEUVPMT-UHFFFAOYSA-N
- SMILES
- S1C=C(C=O)N=C1C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 717231
- Product name
- 2-Methylthiazole-4-carboxaldehyde
- Purity
- 97%
- Packaging
- 500mg
- Price
- $124
- Updated
- 2023/06/20
- Product number
- F701245
- Product name
- 4-Formyl-2-methylthiazole
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- OR5201
- Product name
- 2-Methyl-1,3-thiazole-4-carboxaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 8H15-1-X1
- Product name
- 2-Methyl-1,3-thiazole-4-carboxaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $28
- Updated
- 2021/12/16
- Product number
- OR5201
- Product name
- 2-Methyl-1,3-thiazole-4-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
4-Formyl-2-methylthiazole Chemical Properties,Usage,Production
Chemical Properties
Yellow Powder
Synthesis
6436-59-5
20949-84-2
The general procedure for the synthesis of 2-methyl-4-thiazolecarboxaldehyde using ethyl 2-methylthiazole-4-carboxylate as starting material was as follows: to a solution of ethyl 2-methylthiazole-4-carboxylate (1.00 g, 5.8 mmol) in toluene (18 mL) was slowly added dropwise to a solution of diisobutylaluminum hydroxide in dichloromethane (11.1 mL, 1 M) at -78 °C. After the dropwise addition was completed, the reaction system was kept at -78 °C and stirring was continued for 4 hours. Subsequently, the reaction was quenched by the addition of acetic acid (0.46 mL) and concentrated by slowly warming the reaction mixture to 25 °C. The concentrated residue was treated with dichloromethane and Rochelle's salt with vigorous stirring until a clarified two-phase solution was formed (about 10 min). The organic and aqueous layers were separated, and the organic layer was washed sequentially with 10% NaHCO3 solution and saturated saline, then dried with anhydrous Na2SO4, filtered and concentrated. Finally, the residue was purified by silica gel column chromatography, using 14% ethyl acetate in hexane solution as eluent, to obtain the target product 2-methyl-4-thiazolecarboxaldehyde (0.28 g, 38% yield).
References
[1] Organic Letters, 2008, vol. 10, # 8, p. 1565 - 1568
[2] Angewandte Chemie - International Edition in English, 1997, vol. 36, # 1-2, p. 166 - 168
[3] Journal of the American Chemical Society, 1997, vol. 119, # 34, p. 7974 - 7991
[4] Organic Letters, 2012, vol. 14, # 24, p. 6354 - 6357
[5] Angewandte Chemie - International Edition, 2000, vol. 39, # 1, p. 209 - 213
4-Formyl-2-methylthiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Formyl-2-methylthiazole manufacturers
- Product
- 4-FORMYL-2-METHYLTHIAZOLE 20949-84-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11