PINOCEMBRIN

Product Name: PINOCEMBRIN
CAS No.: 480-39-7
Chemical Name: PINOCEMBRIN
Synonyms: Picembrin;PINOCEMBRIN;pinocemberin;dihydrochrysin;Pinocembrin-RM;PINOCEMBRIN(RG);(+)-Pinocembrin;galanginflavanone;5,7-DIHYDROXYFLAVANONE;Pinocembrin, 10 mM in DMSO
CBNumber: CB3378883
Molecular Formula: C15H12O4
Formula Weight: 256.25
MOL File: 480-39-7.mol

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PINOCEMBRIN Property

Melting point:: 202 °C
Boiling point:: 511.1±50.0 °C(Predicted)
Density: 1.386±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in ethanol and methan
form: powder
pka: 7.50±0.40(Predicted)
color: White
LogP: 3.225 (est)
EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)- (480-39-7)

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Safety

Safety Statements: 24/25
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P5239
Product name: Pinocembrin
Purity: analytical standard, ≥95.0% (HPLC), solid
Packaging: 50 mg
Price: $292.5
Updated: 2025/07/31

Cayman Chemical

Product number: 29852
Product name: Pinocembrin
Packaging: 10mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 29852
Product name: Pinocembrin
Packaging: 250mg
Price: $796
Updated: 2024/03/01

Cayman Chemical

Product number: 29852
Product name: Pinocembrin
Packaging: 50mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 29852
Product name: Pinocembrin
Packaging: 100mg
Price: $363
Updated: 2024/03/01

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PINOCEMBRIN Chemical Properties,Usage,Production

Description

Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities. It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 μM. Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH). It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy. Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.

Chemical Properties

Solid

Uses

Pinocembrin is a flavanoid with antioxidant activity found in damiana, honey, and propolis. Recent studies show that Pinocembrin maybe be a therapeutic option in reducing cerebral ischemia/reperfusion injury as a result of its anti-oxidative and anti-apoptotic effects. Pinocembrin displayed neuroprotective effects in glutamate injury model partly by inhibiting p53 expression causing a lower Bax-Bcl-2 ratio and by inhibiting the release of cytochrome c.

Definition

ChEBI: Pinocembrin is a dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea. It has a role as an antioxidant, an antineoplastic agent, a vasodilator agent, a neuroprotective agent and a metabolite. It is a dihydroxyflavanone and a (2S)-flavan-4-one.

References

[1] AZHAR RASUL. Pinocembrin: a novel natural compound with versatile pharmacological and biological activities.[J]. BioMed Research International, 2013: 379850. DOI: 10.1155/2013/379850
[2] JUN GAO . Pinocembrin inhibits the proliferation and migration and promotes the apoptosis of ovarian cancer cells through down-regulating the mRNA levels of N-cadherin and GABAB receptor[J]. Biomedicine & Pharmacotherapy, 2019, 120: Article 109505. DOI: 10.1016/j.biopha.2019.109505
[3] XI LAN. Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia[J]. Brain, Behavior, and Immunity, 2017, 61: Pages 326-339. DOI: 10.1016/j.bbi.2016.12.012
[4] JESSICA GRANADOS-PINEDA. Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy.[J]. Molecules, 2018, 23 4. DOI: 10.3390/molecules23040852
[5] LANAN WASSY SOROMOU . In vitro and in vivo protection provided by pinocembrin against lipopolysaccharide-induced inflammatory responses[J]. International immunopharmacology, 2012, 14 1: Pages 66-74. DOI: 10.1016/j.intimp.2012.06.009

PINOCEMBRIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PINOCEMBRIN Suppliers

Canada 1 China 247 Germany 2 India 2 Japan 1 United Kingdom 5 United States 18 USA 1 Global 277

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 021-38218169 13341702378
Fax: QQ：190129269
Email: winherb@126.com
Country: China
ProdList: 1245
Advantage: 58

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

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View Lastest Price from PINOCEMBRIN manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Pinocembrin 480-39-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-30

Xi an Biohorlden Industry Trade Co Ltd

Product: Pinocembrin / Herb cardamom extract 480-39-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000
Release date: 2025-04-16

Shaanxi Dideu Medichem Co. Ltd

Product: PINOCEMBRIN 480-39-7
Price: US $1.00-2.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20000KG
Release date: 2024-08-09

480-39-7, PINOCEMBRINRelated Search:

Naringenin NARIRUTIN PONCIRIN ERIODICTYOL-7-GLUCOSIDE 5,7-DIHYDROXY-3',4',5'-TRIMETHOXYFLAVANONE Pinostrobin HESPERETIN ERIOCITRIN PINOCEMBRIN ISOSAKURANETIN 6,8-DIMETHYL-4',5,7-TRIHYDROXYFLAVANONE Neohesperidin PINOCEMBRIN PINOCEMBRIN DIMETHYL ETHER PINOCEMBRIN-7-METHYLETHER(RG),PINOCEMBRIN-7-METHYL ETHER PINOCEMBRIN DIMETHYL ETHER FLAVANONE (+/-)-TAXIFOLIN

5,7-DIHYDROXYFLAVANONE

5,7-DIHYDROXY-3'4'5'-FLAVANONE

5,7-DIHYDROXY-2-PHENYL-CHROMAN-4-ONE

PINOCEMBRIN

(s)-2,3-dihydro-5,7-dihydroxy-2-phenyl-4h-1-benzopyran-4-one

3-dihydro-5,7-dihydroxy-2-phenyl-(s)-4h-1-benzopyran-4-on

dihydrochrysin

galanginflavanone

PINOCEMBRIN(RG)

4H-1-BENZOPYRAN-4-ONE,2,3-DIH

PinoceMbrin, froM Pinus cerebra

(2S)-2-Phenyl-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one

(2S)-2α-Phenyl-5,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one

Picembrin

(2S)-5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one

5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one

Pinocembrin, 98%, from Pinus cerebra

(2S)-5,7-Dihydroxy-2-phenylchroman-4-one

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)-

(S)-5,7-Dihydroxy-2-Phenylchroman-4-One

pinocemberin

(+)-Pinocembrin

Inhibitor,Bacterial,Autophagy,Reactive Oxygen Species,(+)-Pinocoembrin,inhibit,Pinocembrin

Pinocembrin-RM

Pinocembrin, 10 mM in DMSO

Pinocembrin / Herb cardamom extract

480-39-7

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Flavanones