ChemicalBook > CAS DataBase List > PINOCEMBRIN

PINOCEMBRIN

Product Name
PINOCEMBRIN
CAS No.
480-39-7
Chemical Name
PINOCEMBRIN
Synonyms
Picembrin;PINOCEMBRIN;pinocemberin;dihydrochrysin;PINOCEMBRIN(RG);(+)-Pinocembrin;galanginflavanone;5,7-DIHYDROXYFLAVANONE;4H-1-BENZOPYRAN-4-ONE,2,3-DIH;5,7-DIHYDROXY-3'4'5'-FLAVANONE
CBNumber
CB3378883
Molecular Formula
C15H12O4
Formula Weight
256.25
MOL File
480-39-7.mol
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PINOCEMBRIN Property

Melting point:
202 °C
Boiling point:
511.1±50.0 °C(Predicted)
Density 
1.386±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in ethanol and methan
form 
powder
pka
7.50±0.40(Predicted)
color 
White
LogP
3.225 (est)
EPA Substance Registry System
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)- (480-39-7)
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Safety

Safety Statements 
24/25
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29852
Product name
Pinocembrin
Packaging
10mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
29852
Product name
Pinocembrin
Packaging
250mg
Price
$796
Updated
2024/03/01
Cayman Chemical
Product number
29852
Product name
Pinocembrin
Packaging
50mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
29852
Product name
Pinocembrin
Packaging
100mg
Price
$363
Updated
2024/03/01
Biosynth Carbosynth
Product number
XP162085
Product name
(+)-Pinocembrin
Packaging
1g
Price
$550
Updated
2021/12/16
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PINOCEMBRIN Chemical Properties,Usage,Production

Description

Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities. It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 μM. Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH). It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy. Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.

Chemical Properties

Solid

Uses

Pinocembrin is a flavanoid with antioxidant activity found in damiana, honey, and propolis. Recent studies show that Pinocembrin maybe be a therapeutic option in reducing cerebral ischemia/reperfusion injury as a result of its anti-oxidative and anti-apoptotic effects. Pinocembrin displayed neuroprotective effects in glutamate injury model partly by inhibiting p53 expression causing a lower Bax-Bcl-2 ratio and by inhibiting the release of cytochrome c.

Definition

ChEBI: Pinocembrin is a dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea. It has a role as an antioxidant, an antineoplastic agent, a vasodilator agent, a neuroprotective agent and a metabolite. It is a dihydroxyflavanone and a (2S)-flavan-4-one.

PINOCEMBRIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PINOCEMBRIN Suppliers

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View Lastest Price from PINOCEMBRIN manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Pinocembrin 480-39-7
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-12-25
Career Henan Chemical Co
Product
PINOCEMBRIN 480-39-7
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24
Career Henan Chemical Co
Product
PINOCEMBRIN 480-39-7
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

480-39-7, PINOCEMBRINRelated Search:

Naringenin NARIRUTIN PONCIRIN ERIODICTYOL-7-GLUCOSIDE 5,7-DIHYDROXY-3',4',5'-TRIMETHOXYFLAVANONE Pinostrobin HESPERETIN ERIOCITRIN PINOCEMBRIN ISOSAKURANETIN 6,8-DIMETHYL-4',5,7-TRIHYDROXYFLAVANONE Neohesperidin PINOCEMBRIN PINOCEMBRIN DIMETHYL ETHER PINOCEMBRIN-7-METHYLETHER(RG),PINOCEMBRIN-7-METHYL ETHER PINOCEMBRIN DIMETHYL ETHER FLAVANONE (+/-)-TAXIFOLIN

  • 5,7-DIHYDROXYFLAVANONE
  • 5,7-DIHYDROXY-3'4'5'-FLAVANONE
  • 5,7-DIHYDROXY-2-PHENYL-CHROMAN-4-ONE
  • PINOCEMBRIN
  • (s)-2,3-dihydro-5,7-dihydroxy-2-phenyl-4h-1-benzopyran-4-one
  • 3-dihydro-5,7-dihydroxy-2-phenyl-(s)-4h-1-benzopyran-4-on
  • dihydrochrysin
  • galanginflavanone
  • PINOCEMBRIN(RG)
  • 4H-1-BENZOPYRAN-4-ONE,2,3-DIH
  • PinoceMbrin, froM Pinus cerebra
  • (2S)-2-Phenyl-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one
  • (2S)-2α-Phenyl-5,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
  • Picembrin
  • (2S)-5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
  • 5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
  • Pinocembrin, 98%, from Pinus cerebra
  • (2S)-5,7-Dihydroxy-2-phenylchroman-4-one
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)-
  • (S)-5,7-Dihydroxy-2-Phenylchroman-4-One
  • pinocemberin
  • (+)-Pinocembrin
  • Inhibitor,Bacterial,Autophagy,Reactive Oxygen Species,(+)-Pinocoembrin,inhibit,Pinocembrin
  • 480-39-7
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Flavanones