PINOCEMBRIN
- Product Name
- PINOCEMBRIN
- CAS No.
- 480-39-7
- Chemical Name
- PINOCEMBRIN
- Synonyms
- Picembrin;PINOCEMBRIN;pinocemberin;dihydrochrysin;Pinocembrin-RM;PINOCEMBRIN(RG);(+)-Pinocembrin;galanginflavanone;5,7-DIHYDROXYFLAVANONE;Pinocembrin, 10 mM in DMSO
- CBNumber
- CB3378883
- Molecular Formula
- C15H12O4
- Formula Weight
- 256.25
- MOL File
- 480-39-7.mol
PINOCEMBRIN Property
- Melting point:
- 202 °C
- Boiling point:
- 511.1±50.0 °C(Predicted)
- Density
- 1.386±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in ethanol and methan
- form
- powder
- pka
- 7.50±0.40(Predicted)
- color
- White
- LogP
- 3.225 (est)
- EPA Substance Registry System
- 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)- (480-39-7)
Safety
- Safety Statements
- 24/25
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P5239
- Product name
- Pinocembrin
- Purity
- analytical standard, ≥95.0% (HPLC), solid
- Packaging
- 50 mg
- Price
- $292.5
- Updated
- 2025/07/31
- Product number
- 29852
- Product name
- Pinocembrin
- Packaging
- 10mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 29852
- Product name
- Pinocembrin
- Packaging
- 250mg
- Price
- $796
- Updated
- 2024/03/01
- Product number
- 29852
- Product name
- Pinocembrin
- Packaging
- 50mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 29852
- Product name
- Pinocembrin
- Packaging
- 100mg
- Price
- $363
- Updated
- 2024/03/01
PINOCEMBRIN Chemical Properties,Usage,Production
Description
Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities. It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 μM. Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH). It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy. Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.
Chemical Properties
Solid
Uses
Pinocembrin is a flavanoid with antioxidant activity found in damiana, honey, and propolis. Recent studies show that Pinocembrin maybe be a therapeutic option in reducing cerebral ischemia/reperfusion injury as a result of its anti-oxidative and anti-apoptotic effects. Pinocembrin displayed neuroprotective effects in glutamate injury model partly by inhibiting p53 expression causing a lower Bax-Bcl-2 ratio and by inhibiting the release of cytochrome c.
Definition
ChEBI: Pinocembrin is a dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea. It has a role as an antioxidant, an antineoplastic agent, a vasodilator agent, a neuroprotective agent and a metabolite. It is a dihydroxyflavanone and a (2S)-flavan-4-one.
References
[1] AZHAR RASUL. Pinocembrin: a novel natural compound with versatile pharmacological and biological activities.[J]. BioMed Research International, 2013: 379850. DOI: 10.1155/2013/379850
[2] JUN GAO . Pinocembrin inhibits the proliferation and migration and promotes the apoptosis of ovarian cancer cells through down-regulating the mRNA levels of N-cadherin and GABAB receptor[J]. Biomedicine & Pharmacotherapy, 2019, 120: Article 109505. DOI: 10.1016/j.biopha.2019.109505
[3] XI LAN. Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia[J]. Brain, Behavior, and Immunity, 2017, 61: Pages 326-339. DOI: 10.1016/j.bbi.2016.12.012
[4] JESSICA GRANADOS-PINEDA. Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy.[J]. Molecules, 2018, 23 4. DOI: 10.3390/molecules23040852
[5] LANAN WASSY SOROMOU . In vitro and in vivo protection provided by pinocembrin against lipopolysaccharide-induced inflammatory responses[J]. International immunopharmacology, 2012, 14 1: Pages 66-74. DOI: 10.1016/j.intimp.2012.06.009
PINOCEMBRIN Preparation Products And Raw materials
Raw materials
Preparation Products
PINOCEMBRIN Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
View Lastest Price from PINOCEMBRIN manufacturers
- Product
- Pinocembrin 480-39-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2025-04-30
- Product
- Pinocembrin / Herb cardamom extract 480-39-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000
- Release date
- 2025-04-16
- Product
- PINOCEMBRIN 480-39-7
- Price
- US $1.00-2.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-08-09