6(5H)-Phenanthridone

Product Name: 6(5H)-Phenanthridone
CAS No.: 1015-89-0
Chemical Name: 6(5H)-Phenanthridone
Synonyms: PJ 97A;NSC 11021;NSC 40943;NSC 61083;WD 99-004344;Phenantridone;PHENANTHRIDONE;PHENANTHRIDINONE;6-Phenanthridone;6-Phenanthridinol
CBNumber: CB3386736
Molecular Formula: C13H9NO
Formula Weight: 195.22
MOL File: 1015-89-0.mol

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6(5H)-Phenanthridone Property

Melting point:: 290-292 °C(lit.)
Boiling point:: 435 °C
Density: 1.230±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMF: 1mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16mg/mL
pka: 13.27±0.20(Predicted)
form: powder to crystal
color: White to Light yellow to Light orange
Water Solubility: Soluble in DMSO (5 mg/ml). Insoluble in water.
λmax: 338nm(EtOH)(lit.)
BRN: 140641
InChI: InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
InChIKey: RZFVLEJOHSLEFR-UHFFFAOYSA-N
SMILES: C1=C2C(NC(=O)C3=C2C=CC=C3)=CC=C1
CAS DataBase Reference: 1015-89-0(CAS DataBase Reference)
NIST Chemistry Reference: 6(5H)-phenanthridinone(1015-89-0)
EPA Substance Registry System: 6-Phenanthridinone (1015-89-0)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: SG0370000
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 299634
Product name: 6-(5H)-Phenanthridinone
Purity: technical grade
Packaging: 1g
Price: $62.98
Updated: 2025/07/31

TCI Chemical

Product number: P1998
Product name: 6(5H)-Phenanthridinone
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: P1998
Product name: 6(5H)-Phenanthridinone
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $104
Updated: 2025/07/31

Cayman Chemical

Product number: 28730
Product name: 6(5H)-Phenanthridinone
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 28730
Product name: 6(5H)-Phenanthridinone
Packaging: 25mg
Price: $510
Updated: 2024/03/01

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6(5H)-Phenanthridone Chemical Properties,Usage,Production

Uses

6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation.

Uses

6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.

Definition

ChEBI: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.

Synthesis Reference(s)

Canadian Journal of Chemistry, 35, p. 180, 1957 DOI: 10.1139/v57-027
Journal of the American Chemical Society, 79, p. 1245, 1957 DOI: 10.1021/ja01562a054

General Description

6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.

6(5H)-Phenanthridone Preparation Products And Raw materials

Raw materials

Preparation Products

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6(5H)-Phenanthridone Suppliers

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View Lastest Price from 6(5H)-Phenanthridone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 6(5H)-Phenanthridone 1015-89-0
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Shanghai UCHEM Inc.

Product: 6(5H)-Phenanthridone 1015-89-0
Price: US $44.00-593.00/g
Min. Order: 25g
Purity: 0.98
Supply Ability: 25kg
Release date: 2023-12-11

Hebei Chuanghai Biotechnology Co,.LTD

Product: 6(5H)-Phenanthridone 1015-89-0
Price: US $10.70/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

1015-89-0, 6(5H)-PhenanthridoneRelated Search:

2,8-DICHLORO-QUINOLINE-3-CARBALDEHYDE 2-Chloro-5-fluorobenzonitrile N-PHENYLETHYLENEDIAMINE Isoquinoline, 6-chloro- (6CI,9CI) Norethindrone Phenanthridine Fanthridone PJ-34 6(5H)-Phenanthridone ISOMETAMIDIUM N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N DIMETHYLACETAMIDE HYDROCHLORIDE HYDRATE 4H-CYCLOPENTA[LMN]PHENANTHRIDINE 5,9-DIONE 6(5H)-PHENANTHRIDINONE, 1,3,8,9-TETRAMETHOXY- 6(5H)-PHENANTHRIDINONE, 1,3,8,9-TETRAMETHOXY-5-METHYL- 6(5H)-PHENANTHRIDINONE, 8,9-DIMETHOXY- 2,3-DIMETHOXY-12-METHYL-12H-[1,3]DIOXOLO-[4',5':4,5]BENZO[1,2-C]PHENANTHRIDIN-13-ONE 6(5H)-PHENANTHRIDINONE, 3,8,9-TRIMETHOXY- 6(5H)-PHENANTHRIDINONE, 3,8,9-TRIMETHOXY-5-METHYL-

PHENANTHRIDINONE

PHENANTHRIDONE

6(5H)-Phenantridinone

6-Phenanthridinol

6-Phenanthridone

Phenantridone

2H-BENZ[C]ISOQUINOLIN-1-ONE

phenanthridin-6(5H)-one

3,7-DIAMINO-2-METHOXYFLUOREN 98%

6(5H)-PHENANTHRIDINONE 97%

6-PHENANTHRIDINONE

5,6-Dihydrophenanthridin-6-one

5,6-Dihydrophenanthridine-6-one

Benzo[c]quinoline-6(5H)-one

5H-phenanthridin-6-one

NSC 11021

NSC 40943

NSC 61083

PJ 97A

WD 99-004344

phenantridine-6(5H)-one

Phenanthridone (misnomer)

6(5H)-PHENANTHRIDINONE

6(5H)-PHENANTHRIDONE

6-(5H)-Phenanthridinone, 97%+

6(5H)-Phenanthridinone&gt

Quetiapine Impurity 56

Phenanthridine ketone

6-(5<i>H</i>)-Phenanthridinone

6(5H)-Phenanthridinone - [P72055]

6(5H)-Phenthridinone

1015-89-0

Building Blocks

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Pyrazoles

Heterocyclic Building Blocks

N-Containing

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Heterocyclic Building Blocks