ChemicalBook > CAS DataBase List > 2-Methoxypyridine

2-Methoxypyridine

Product Name
2-Methoxypyridine
CAS No.
1628-89-3
Chemical Name
2-Methoxypyridine
Synonyms
2-METHOXYPYRIDINE;2-Methoxyl pyridine;2-Methoxypyridine>2-Methoxypyridine98%;2-Methoxypyridine 99%;2-Pyridol methyl ether;METHYL 2-PYRIDYL ETHER;Methyl pyridin-2-yl ether;2-METHOXY PYRIDINE FEMA NO.--------;2-Methoxypyridine ISO 9001：2015 REACH
CBNumber
CB3396719
Molecular Formula
C6H7NO
Formula Weight
109.13
MOL File
1628-89-3.mol
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2-Methoxypyridine Property

Boiling point:
142 °C (lit.)
Density 
1.038 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.503(lit.)
FEMA 
4639 | 2-METHOXYPYRIDINE
Flash point:
90 °F
storage temp. 
Inert atmosphere,Room Temperature
form 
Liquid
pka
3.28(at 20℃)
color 
Clear colorless to slightly yellow
Odor
at 0.10?%?in?propylene glycol. green fermented tea
Appearance
Colorless to Light yellow clear liquid
Water Solubility 
INSOLUBLE
JECFA Number
2156
BRN 
108189
InChIKey
IWTFOFMTUOBLHG-UHFFFAOYSA-N
LogP
1.32
CAS DataBase Reference
1628-89-3(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2-methoxy-(1628-89-3)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
10-36/37/38
Safety Statements 
26-36-16
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
HazardClass 
3
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W463901
Product name
2-Methoxypyridine
Purity
≥98%
Packaging
100G
Price
$109
Updated
2025/07/31
Sigma-Aldrich
Product number
W463901
Product name
2-Methoxypyridine
Purity
≥98%
Packaging
1 unit
Price
$174
Updated
2025/07/31
Sigma-Aldrich
Product number
W463901
Product name
2-Methoxypyridine
Purity
≥98%
Packaging
1 unit
Price
$174
Updated
2025/07/31
Sigma-Aldrich
Product number
W463901
Product name
2-Methoxypyridine
Purity
≥98%
Packaging
1KG
Price
$428
Updated
2025/07/31
Sigma-Aldrich
Product number
M25406
Product name
2-Methoxypyridine
Purity
98%
Packaging
25g
Price
$41.9
Updated
2025/07/31
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2-Methoxypyridine Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

2-Methoxypyridine can be used as an intermediate to synthesize 2-methoxy-3-pyridinesulfonyl chloride which is patented as a reactant used to prepare erythromycin macrolide antibiotics as antibacterial and antiprotozoal agents. It can also be used to prepare bicyclic iminopyrimidinones as Beta Amyloid Cleaving Enzyme-1 (BACE1) inhibitors.

Synthesis

CsSO4F may be used to fluorinate pyridine directly, but the reaction is very sensitive to the solvents employed. When solvents such as pentane and diethyl ether were used, 2-fluoropyridine was the major product, but use of nucleophilic solvents, such as methanol gave 2-methoxypyridine.

References

[1] DAI W, LIU S, ZHANG Z, et al. Conformational preferences and isomerization upon excitation/ionization of 2-methoxypyridine and 2-N-methylaminopyridine†[J]. Physical Chemistry Chemical Physics, 2018, 9: 6211-6226. DOI:10.1039/C7CP07854D.
[2] Singh, Avtar, et al. "Synthesis of C-6 and C-3 substituted chalcogen derivatives of 2-methoxypyridine through lithiation of 2-methoxypyridine: An experimental and quantum chemical study." Inorganica Chimica Acta 432 (2015): 109-114.
[3] Trécourt, F., et al. "Catalyzed metalation applied to 2-methoxypyridine." The Journal of Organic Chemistry 53.7 (1988): 1367-1371.
[4] Ahipa, T. N., and Airody Vasudeva Adhikari. "2-Methoxypyridine derivatives: synthesis, liquid crystalline and photo-physical properties." New Journal of Chemistry 38.10 (2014): 5018-5029.
[5] WANYING CHENG . Conformation and bonding of 2-methoxypyridine and its monohydrate from rotational spectra[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 239: Article 118434. DOI:10.1016/j.saa.2020.118434.

2-Methoxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyridinol-1-oxide 6-Methoxynicotinaldehyde 7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE 2-Methoxypyridine-3-boronic acid 2-METHOXY-3-PYRIDINECARBOXALDEHYDE 4-Amino-2-methoxypyridine
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2-Methoxypyridine Suppliers

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View Lastest Price from 2-Methoxypyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Methoxypyridine 1628-89-3
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%min
Supply Ability
1000kg
Release date
2025-09-09
Shanghai Yongzeng Technology Co.,Ltd
Product
2-methoxypyridine 1628-89-3
Price
US $0.00/gm
Min. Order
100gm
Purity
99%min
Supply Ability
100kgs
Release date
2024-09-04
JINING XINHE CHEMICAL CO., LTD
Product
2-Methoxypyridine 1628-89-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10ton
Release date
2024-07-17

1628-89-3, 2-MethoxypyridineRelated Search:

2,6-Dimethoxypyridine 2-Methoxy-3-nitropyridine 6-Chloro-2-methoxypyridine 2-PHENOXYNICOTINONITRILE 3-AMINO-2,6-DIMETHOXYPYRIDINE MONOHYDROCHLORIDE 2-Methoxypyridine 2-PHENOXYNICOTINIC ACID 2-ALLYLOXYPYRIDINE 2-N-BUTOXYPYRIDINE 2-CHLORO-6-ETHOXYPYRIDINE 2-Ethoxypyridine 2-Methoxy-5-nitropyridine Pyridine,3,4-dimethoxy-(9CI) 5-FLUORO-2-METHOXYPYRIDINE 6-METHOXYPYRIDINE-2-CARBOXYLIC ACID 2-(2-FORMYL-1H-PYRROL-1-YL)-4-METHOXYNICOTINONITRILE 5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE 6-methoxypyridine-2,3-diamine dihydrochloride

  • METHYL 2-PYRIDYL ETHER
  • 2-METHOXYPYRIDINE
  • 2-Methoxypyridine98%
  • 2-Methoxypyridine 99%
  • Methyl pyridin-2-yl ether
  • 2-Methoxyl pyridine
  • 2-Pyridol methyl ether
  • 2-METHOXY PYRIDINE FEMA NO.--------
  • 2-Methoxypyridine&gt
  • 2-Methoxypyridine ISO 9001：2015 REACH
  • 1628-89-3
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyridines
  • C6
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridines derivates
  • Pyridines
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Miscellaneous Compounds
  • Heterocyclic Building Blocks
  • Pyridine
  • bc0001
  • C6