3-FLUORO-5-IODOANILINE
- Product Name
- 3-FLUORO-5-IODOANILINE
- CAS No.
- 660-49-1
- Chemical Name
- 3-FLUORO-5-IODOANILINE
- Synonyms
- 3-FLUORO-5-IODOANILINE;5-FLUORO-3-IODOANILINE;3-Fluoro-5-iodoaniline,96%;3-FLUORO-5-IODO-PHENYLAMINE;Benzenamine, 3-fluoro-5-iodo-
- CBNumber
- CB3398647
- Molecular Formula
- C6H5FIN
- Formula Weight
- 237.01
- MOL File
- 660-49-1.mol
3-FLUORO-5-IODOANILINE Property
- Boiling point:
- 279.5±25.0 °C(Predicted)
- Density
- 2.008±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.62±0.10(Predicted)
- Appearance
- Brown to reddish brown Liquid
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 660-49-1(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F592160
- Product name
- 3-Fluoro-5-iodoaniline
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- F592160
- Product name
- 3-Fluoro-5-iodoaniline
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC5888
- Product name
- 3-Fluoro-5-iodoaniline
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 3630-K-35
- Product name
- 3-Fluoro-5-iodoaniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 119140
- Product name
- 3-Fluoro-5-iodoaniline
- Purity
- 96%
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
3-FLUORO-5-IODOANILINE Chemical Properties,Usage,Production
Synthesis
3819-88-3
660-49-1
1. A suspension of 1-fluoro-3-iodo-5-nitrobenzene (0.5 g, 1.87 mmol) with SnCl2-2H2O (1.5 g, 6.64 mmol) in ethanol (10 mL) was heated to reflux for 1.5 hours. After completion of the reaction, the solvent was removed under reduced pressure and the crude product was diluted with ether and washed sequentially with 4N NaOH solution and saturated saline. The ether layer was separated, dried with anhydrous Na2SO4, filtered and concentrated to give the amine compound as a solid (0.4 g, 91% yield). The crude product can be used directly in the next step of the reaction. 2. A mixture of amine (0.4 g, 1.69 mmol), iodomethane (0.719 g, 5 mmol) and potassium carbonate (0.46 g, 3.38 mmol) obtained above in N,N-dimethylformamide (DMF; 10 mL) was stirred at room temperature for 48 hours. After completion of the reaction, water (10 mL) was added and extracted three times with ether. The organic extracts were combined, washed sequentially with water and saturated saline, dried over anhydrous Na2SO4, filtered and concentrated. The crude product was purified by column chromatography to afford 3-fluoro-5-iodo-N,N-dimethylaniline (VMY-2-119) as liquid (0.23 g, 52% yield). 1H NMR (399 MHz, CDCl3) δ: 6.69-6.63 (m, 2H), 6.22 (dt, J = 12.5, 2.3 Hz, 1H), 2.83 (s, 6H). 13C NMR (100 MHz, CDCl3) δ: 163.33 (d, JF-C = 245 Hz), 152.49 (d, J = 11 Hz), 116.91 (d, J = 2.4 Hz), 112.12 (d, J = 24 Hz), 98.73 (d, J = 26 Hz), 94.24 (d, J = 11 Hz), 40.21 (s, 3H). 40.21 (s, 3H).
References
[1] Patent: WO2013/71067, 2013, A1. Location in patent: Page/Page column 42-43
[2] Chemical and Pharmaceutical Bulletin, 2005, vol. 53, # 2, p. 153 - 163
[3] Journal of Organic Chemistry, 1960, vol. 25, p. 1342 - 1348
[4] Patent: EP1382603, 2004, A1. Location in patent: Page 170
[5] Patent: US6821980, 2004, B1. Location in patent: Page column 40-41
3-FLUORO-5-IODOANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-5-IODOANILINE manufacturers
- Product
- 3-FLUORO-5-IODOANILINE 660-49-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-13
- Product
- 3-FLUORO-5-IODOANILINE 660-49-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 200kg
- Release date
- 2020-03-06