ChemicalBook > CAS DataBase List > 4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE

4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE

Product Name
4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE
CAS No.
162641-16-9
Chemical Name
4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE
Synonyms
CS-620;HQL-97;HQL-79;HQL 79;HQL79;4-benzhydryloxy-1-[3-(2H-tetrazol-5-yl)propyl]piperidine;1-(3-(1H-Tetrazol-5-yl)propyl)-4-(benzhydryloxy)piperidine;4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine;4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE;Piperidine, 4-(diphenylmethoxy)-1-[3-(2H-tetrazol-5-yl)propyl]-
CBNumber
CB3399336
Molecular Formula
C22H27N5O
Formula Weight
377.48
MOL File
162641-16-9.mol
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4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE Property

Boiling point:
553.6±60.0 °C(Predicted)
Density 
1.21
storage temp. 
Store at RT
solubility 
DMSO: soluble2mg/mL, clear (warmed)
form 
powder
pka
4.85±0.10(Predicted)
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0857
Product name
HQL 79
Purity
≥98% (HPLC)
Packaging
5mg
Price
$72.5
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0857
Product name
HQL 79
Purity
≥98% (HPLC)
Packaging
25mg
Price
$417
Updated
2025/07/31
Cayman Chemical
Product number
10134
Product name
HQL 79
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
10134
Product name
HQL 79
Purity
≥98%
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
10134
Product name
HQL 79
Purity
≥98%
Packaging
10mg
Price
$146
Updated
2024/03/01
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4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE Chemical Properties,Usage,Production

Uses

HQL-79 is a selective PGE synthase inhibitor.

Biological Activity

HQL 79 is an orally active anti-allergic agent th at acts as an antagonist for histamine H1 receptors (H1R), eliciting anti-asthmatic effects. It interacts with prostaglandin (PG) D synthase (H-PGDS) in the catalytic region. It may be potential lead due to its H-PGDS inhibition to tre at allergies.', 'HQL-79 is a selective inhibtor of hematopoietic prostaglandin D (PGD) synthase, one of two synthases involved in the production of Prostaglandin D2 (PGD2) from arachidonic acid. PGD2 is a lipid signaling molecule, which activates two receptors, DP1 involved in centrally mediated processes such as sleep and pain and DP2 involved and inflammation. The two PGD synthases involved in its synthesis are lipocalin-type (L-PGDS) and hematopoietic (H-PDGS), which acts to form PGD2 in mast cells, Th2 cells, microglia, and other inflammatory cells/tissues. HQL-79 selectively inhibited the activity of recombinant H-PGDS with an IC50 of 6 μM and had almost no effect on COX-1, COX-2, m-PGES, or L-PGDS up to 300 μM. HQL-79 has anti-inflammatory activity in vitro and in vivo.

storage

Store at RT

4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE manufacturers

Career Henan Chemical Co
Product
4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE 162641-16-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-13

162641-16-9, 4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINERelated Search:


  • HQL-79
  • 4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine
  • HQL-97
  • 4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE
  • CS-620
  • HQL 79;HQL79
  • Piperidine, 4-(diphenylmethoxy)-1-[3-(2H-tetrazol-5-yl)propyl]-
  • 1-(3-(1H-Tetrazol-5-yl)propyl)-4-(benzhydryloxy)piperidine
  • 4-benzhydryloxy-1-[3-(2H-tetrazol-5-yl)propyl]piperidine
  • 162641-16-9
  • C22H27N5O