4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE
- Product Name
- 4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE
- CAS No.
- 162641-16-9
- Chemical Name
- 4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE
- Synonyms
- CS-620;HQL-97;HQL-79;HQL 79;HQL79;4-benzhydryloxy-1-[3-(2H-tetrazol-5-yl)propyl]piperidine;1-(3-(1H-Tetrazol-5-yl)propyl)-4-(benzhydryloxy)piperidine;4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine;4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE;Piperidine, 4-(diphenylmethoxy)-1-[3-(2H-tetrazol-5-yl)propyl]-
- CBNumber
- CB3399336
- Molecular Formula
- C22H27N5O
- Formula Weight
- 377.48
- MOL File
- 162641-16-9.mol
4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE Property
- Boiling point:
- 553.6±60.0 °C(Predicted)
- Density
- 1.21
- storage temp.
- Store at RT
- solubility
- DMSO: soluble2mg/mL, clear (warmed)
- form
- powder
- pka
- 4.85±0.10(Predicted)
- color
- white to beige
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0857
- Product name
- HQL 79
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $97.6
- Updated
- 2024/03/01
- Product number
- SML0857
- Product name
- HQL 79
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $478
- Updated
- 2024/03/01
- Product number
- 10134
- Product name
- HQL 79
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 10134
- Product name
- HQL 79
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 10134
- Product name
- HQL 79
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $146
- Updated
- 2024/03/01
4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE Chemical Properties,Usage,Production
Uses
HQL-79 is a selective PGE synthase inhibitor.
Biological Activity
HQL 79 is an orally active anti-allergic agent th at acts as an antagonist for histamine H1 receptors (H1R), eliciting anti-asthmatic effects. It interacts with prostaglandin (PG) D synthase (H-PGDS) in the catalytic region. It may be potential lead due to its H-PGDS inhibition to tre at allergies.', 'HQL-79 is a selective inhibtor of hematopoietic prostaglandin D (PGD) synthase, one of two synthases involved in the production of Prostaglandin D2 (PGD2) from arachidonic acid. PGD2 is a lipid signaling molecule, which activates two receptors, DP1 involved in centrally mediated processes such as sleep and pain and DP2 involved and inflammation. The two PGD synthases involved in its synthesis are lipocalin-type (L-PGDS) and hematopoietic (H-PDGS), which acts to form PGD2 in mast cells, Th2 cells, microglia, and other inflammatory cells/tissues. HQL-79 selectively inhibited the activity of recombinant H-PGDS with an IC50 of 6 μM and had almost no effect on COX-1, COX-2, m-PGES, or L-PGDS up to 300 μM. HQL-79 has anti-inflammatory activity in vitro and in vivo.
storage
Store at RT
4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE Suppliers
- Tel
- --
- Fax
- --
- alexis-ch@alexis-corp.com
- Country
- Switzerland
- ProdList
- 1104
- Advantage
- 80
View Lastest Price from 4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE manufacturers
- Product
- 4-(DIPHENYLMETHOXY)-1-[3-(1H-TETRAZOL-5-YL)PROPYL]-PIPERIDINE 162641-16-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-13