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BAPTA

Product Name
BAPTA
CAS No.
85233-19-8
Chemical Name
BAPTA
Synonyms
BAPTA;CS-2002;BAPTA,97%;BAPTA, >=98%;BAPTA, Free Acid;1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'- TETRAACETI;ETHYLENEDIOXYBIS(O-PHENYLENENITRILO)TETRAACETIC ACID;Ethylenebis(oxy-2,1-phenylenenitrilo)tetraacetic acid;1,2-Bis-(2-amino-phenoxy)ethane N,N,N',N'-tetraacetic;1,2-Bis-(2-Aminophenoxy) Ethane-N,N,N,-Tetra Acetic Acid
CBNumber
CB3406887
Molecular Formula
C22H24N2O10
Formula Weight
476.43
MOL File
85233-19-8.mol
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BAPTA Property

Melting point:
177-179 °C
Boiling point:
575.89°C (rough estimate)
Density 
1.4482 (rough estimate)
refractive index 
1.6500 (estimate)
RTECS 
MC0423000
storage temp. 
2-8°C
solubility 
Soluble in dimethyl sulfoxide
form 
Powder
pka
1.40±0.10(Predicted)
color 
White to off-white
Water Solubility 
Soluble in water and sodium bicarbonate.
λmax
209 nm, 254 nm, 203 nm, 274 nm
Merck 
14,957
BRN 
5192406
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Biological Applications
Calcium indicators; zinc indicators; treating acute cell death,cerebral infarction,myocardial infarction,hepatonecrosis,kidney ischemic necrosis,necrotizing pancreatitis,amyloidosis,atherosclerosis,diseases characteriz
InChIKey
FTEDXVNDVHYDQW-UHFFFAOYSA-N
CAS DataBase Reference
85233-19-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
14510
Product name
1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid
Purity
≥96.0% (HPLC)
Packaging
100MG
Price
$34.56
Updated
2024/03/01
Sigma-Aldrich
Product number
14510
Product name
1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid
Purity
≥96.0% (HPLC)
Packaging
250MG
Price
$82
Updated
2024/03/01
Sigma-Aldrich
Product number
14510
Product name
1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid
Purity
≥96.0% (HPLC)
Packaging
1G
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
14510
Product name
1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid
Purity
≥96.0% (HPLC)
Packaging
50G
Price
$3510
Updated
2024/03/01
TCI Chemical
Product number
B3895
Product name
1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid
Purity
>97.0%(HPLC)
Packaging
1g
Price
$134
Updated
2024/03/01
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BAPTA Chemical Properties,Usage,Production

Description

BAPTA free acid (85233-19-8) is a selective extracellular Ca2+ chelator. It is a widely used calcium sponge for chelating Ca2+?outside of intact cells.1 It’s a useful tool to probe the involvement of extracellular Ca2+ in cellular signaling.2,3 Non-cell-permeable.

Chemical Properties

White Solid

Uses

Highly selective calcium chelating reagent. Suitable for the spectrophotometric monitoring of Ca2+ levels.

Uses

BAPTA is a highly selective calcium chelating reagent. Lipophilic diesters of the chelating agent 1,2-Bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) are used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE.

Uses

As calcium chelator; 19F labelled forms for measurement of intracellular calcium.

Definition

ChEBI: A polyamino carboxylic acid in which bis(carboxymethyl)nitrilo groups are bonded to C-2 and C-2' of 1,1'-[ethane-1,2-diylbis(oxy)]dibenzene.

General Description

In nature 1,2-Bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetra acetic acid (BAPTA) is a main metabolic product of BAPTA -AM (BAPTA-tetra(actoxymethyl ester), a neuro protective agent in cerebral ischemia, in rats.BAPTA is an intercellular Ca2+ chelator.

Biological Activity

Selective calcium chelator.

storage

Store at +4°C

References

1) Munoz et al. (2015), Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus; PLoS One, 10(9) e0138008 2) Wozniak et al. (2017), Extracellular Ca2+ is Required for Fertilization in the African Clawed Frog, Xenopus laevis; PLoS One, 12(1) e0170405 3) Didiasova et al. (2015), STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization; J. Biol. Chem., 290 11983

BAPTA Preparation Products And Raw materials

Raw materials

Sodium dithionite Ammonium hydroxide Hydrazinium hydroxide solution Acetonitrile Ethanol N,N-Dimethylformamide 2-Nitrophenol N,N-Diisopropylethylamine Palladium Sodium iodide Ethyl bromoacetate 1,2-Dibromoethane Hydrochloric acid Hydrogen Dichloromethane Acetic acid Methanol Sodium hydroxide

Preparation Products

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BAPTA Suppliers

Americas 1 Belgium 1 Canada 1 China 115 Europe 2 Germany 2 India 7 Japan 3 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 7 United States 27 Global 171
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
CMS Chemicals Limited
Tel
--
Fax
--
Email
cms.marketing@cms-chemicals.com
Country
United Kingdom
ProdList
3708
Advantage
60
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
MOLEKULA Ltd.
Tel
--
Fax
--
Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
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View Lastest Price from BAPTA manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1,2-Bis(2-Aminophenoxy)ethane-N,N,N",N"-tetraacetic acid 98% 85233-19-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
BAPTA 85233-19-8
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

85233-19-8, BAPTARelated Search:

RHOD-2, AM BAPTA BAPTA-AM Fura 2-AM Fluo 3-AM BAPTA TETRASODIUM SALT HYDRATE, 98+%,BAPTA-NA4,BAPTA, TETRASODIUM SALT BAPTA, 5,5'-DIBROMO-, TETRASODIUM SALT,5,5'-DIBROMO-BAPTA BAPTA POTASSIUM,BAPTA TETRAPOTASSIUM SALT,BAPTA(K+ SALT),BAPTA 4K BAPTA TETRAETHYL ESTER,BAPTA TETRAETHYL ESTER, 98+% FURA 2 PENTAPOTASSIUM SALT FURA 2 1-[2-(5-CARBOXYOXAZOL-2-YL)-6-AMINOBENZOFURAN-5-OXY]-2-(2'-AMINO-5'-METHYLPHENOXY)-ETHANE-N,N,N',N'-TETRAACETIC ACID, 5NA FLUO 3 INDO 1-AM NITR 5/AM INDO 1 PENTAPOTASSIUM SALT BAPTA, TETRACESIUM SALT BAPTA-TMFM

  • BAPTA
  • ETHYLENEDIOXYBIS(O-PHENYLENENITRILO)TETRAACETIC ACID
  • 1,2-BIS-(O-AMINOPHENOXY)-ETHANE-N,N,N',N'-TETRAACETIC ACID
  • 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID
  • BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid, 2,2μ-(Ethylenedioxy)dianiline-N,N,Nμ,Nμ-tetraacetic acid
  • BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid
  • 1,2-BIS(2-AMINOPHENOXY)-ETHANE-N,N,N',N'- TETRAACETIC ACID 97%
  • 2,2',2'',2'''-[Ethylenebisoxybis(2,1-phenylenenitrilo)]tetrakisacetic acid
  • Ethylenebis(oxy-2,1-phenylenenitrilo)tetraacetic acid
  • 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'- TETRAACETI
  • 1,2-Bis-(2-Aminophenoxy) Ethane-N,N,N,-Tetra Acetic Acid
  • BAPTA (1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N'',N'' -TETRAACETIC ACID)
  • CS-2002
  • N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxyMethyl)glycine
  • Glycine, N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxyMethyl)-
  • 1,2-Bis(2-aMinophenoxy)ethane-N,N,N',N'-tetraacetic acid >=96.0% (HPLC)
  • 2,2',2'',2'''-(((ETHANE-1,2-DIYLBIS(OXY))BIS(2,1-PHENYLENE))BIS(AZANETRIYL))TETRAACETIC ACID
  • BAPTA, >=98%
  • 2,2'-((2-(2-(3-(Bis(carboxymethyl)amino)phenoxy)-ethoxy)phenyl)azanediyl)diacetic acid
  • 1,2-bis(2-aminophenoxy)ethane-n,n,n0, n0-tetraacetic Acid
  • 1,2-bis(o-aminophenoxy)ethane-n,n, n0,n0-tetraacetic Acid
  • 2,20-(ethylenedioxy)dianiline-n,n,n0, n0-tetraacetic Acid
  • BAPTA, Free Acid
  • 1,2-Bis(2-aminophenoxy)-ethane-N,N,N'N'-tetraacetic acid,97%
  • BAPTA,97%
  • 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid &gt
  • 1,2-Bis-(2-amino-phenoxy)ethane N,N,N',N'-tetraacetic
  • 2-[2-[2-[2-[bis(carboxymethyl)amino]phenoxy]ethoxy]-N-(carboxymethyl)anilino]acetic acid
  • 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid
  • 2,2',2'',2'''-(((Ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(azanetriyl))tetraacetic acid
  • Glycine,N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)-
  • 85233-19-8
  • C22H24N2O10
  • C22H20N2O10
  • Detection
  • Fluorescent Probes, Labels, Particles and Stains
  • Intracellular Calcium Signaling
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Calcium Chelators
  • Calcium Signaling Research Tools
  • BioChemical
  • Biochemicals and Reagents
  • Aromatic
  • Amines
  • Aromatics
  • Chelating Agents & Ligands
  • Fluorescent Labels & Indicators