TYRPHOSTIN AG 126

ChemicalBook > CAS DataBase List > TYRPHOSTIN AG 126

Product Name: TYRPHOSTIN AG 126
CAS No.: 118409-62-4
Chemical Name: TYRPHOSTIN AG 126
Synonyms: ag127;AG 126;A -126;TYRPHOSTIN A10;Tyrphostin 126;TYRPHOSTIN AG 126;RARECHEM AL BX 0673;AG126, 10 mM in DMSO;AG 126; AG126; AG-126;TYRPHOSTIN AG 126 USP/EP/BP
CBNumber: CB3407273
Molecular Formula: C10H5N3O3
Formula Weight: 215.16
MOL File: 118409-62-4.mol

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TYRPHOSTIN AG 126 Property

storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: ≤0.15mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
form: Yellow solid
color: Light yellow to yellow
Sensitive: Light Sensitive

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Safety

Hazard Codes: T
Risk Statements: 23/24/25
Safety Statements: 26-36-45
WGK Germany: 3
HazardClass: 6.1
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 658452
Product name: AG 126
Packaging: 5mg
Price: $187
Updated: 2024/03/01

Alfa Aesar

Product number: J67211
Product name: Tyrphostin AG-126
Packaging: 5mg
Price: $132
Updated: 2021/12/16

Cayman Chemical

Product number: 13297
Product name: AG 126
Purity: ≥95%
Packaging: 1mg
Price: $28
Updated: 2024/03/01

Cayman Chemical

Product number: 13297
Product name: AG 126
Purity: ≥95%
Packaging: 5mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 13297
Product name: AG 126
Purity: ≥95%
Packaging: 10mg
Price: $154
Updated: 2024/03/01

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TYRPHOSTIN AG 126 Chemical Properties,Usage,Production

Definition

ChEBI: 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile is a nitrophenol.

Biological Activity

ag-126 is an erk1 and erk2 inhibitor.extracellular signal-regulated kinases (erks) are widely expressed intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions. many different stimuli, such as growth factors, cytokines, transforming agents, and carcinogens, can activate the erk pathway.

in vitro

previous study found that r ag126 ould potently inhibit the pcw-evoked release and this effect was rather selective with respect to the stimulus. ag126 was found to be less potent in attenuating lps-triggered release. moreover, it was found that ag126 was able to prevent the pcw-inducible erk phosphorylation, which could relate to the ag126-mediated inhibition of pcw-evoked cytokine release [1].

in vivo

ag126 was tested in a model of pcw-induced meningitis, in which rats underwent intracisternal injection of pcw with and without ag126 pretreatment. pcw injection led to a dramatic leukocyte influx into the csf. ag126 treatment could significantly attenuate such invasion, without changing the number of circulating leukocytes. in addition, ag126 treatment showed beneficial effects on other parameters, such as intracranial pressure. furthermore, ag126 had no adverse effect on several physiological parameters including mean arterial blood pressure, arterial pao2, paco2 as well as ph [1].

IC 50

inhibits the phosphorylation of erk1 and erk2 at 25-50 μm

References

[1] hanisch, u. k.,prinz, m.,angstwurm, k., et al. the protein tyrosine kinase inhibitor ag126 prevents the massive microglial cytokine induction by pneumococcal cell walls. european journal of immunology 31, 2104-2115 (2001).

TYRPHOSTIN AG 126 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TYRPHOSTIN AG 126 manufacturers

Career Henan Chemical Co

Product: TYRPHOSTIN AG 126 118409-62-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-24

118409-62-4, TYRPHOSTIN AG 126Related Search:

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TYRPHOSTIN AG 126

ag127

AG 126

ALPHA-CYANO-(3-HYDROXY-4-NITRO)CINNAMONITRILE

[3-HYDROXY-4-NITROBENZYLIDENE]MALONONITRILE

Tyrphostin 126

AG 126 - CAS 118409-62-4 - Calbiochem

AG 126; AG126; AG-126

Propanedinitrile, 2-[(3-hydroxy-4-nitrophenyl)methylene]-

2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile

2-(3-Hydroxy-4-nitrobenzylidene)malononitrile

TYRPHOSTIN AG 126 USP/EP/BP

Extracellular signal regulated kinases,BRMECs,Tyrphostin AG 126,ERK,AG-126,Inhibitor,Tyrphostin AG-126,inhibit,AG126,ARPE-19

A -126

AG-126, Tyrosine kinase inhibitor

AG126, 10 mM in DMSO

118409-62-4

C10H5N3O3

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Kinase/Phosphatase Biology

Receptor Tyrosine Kinase Inhibitors

Tyrosine Kinase (TK)

API