ChemicalBook > CAS DataBase List > TYRPHOSTIN AG 126

TYRPHOSTIN AG 126

Product Name
TYRPHOSTIN AG 126
CAS No.
118409-62-4
Chemical Name
TYRPHOSTIN AG 126
Synonyms
ag127;AG 126;A -126;TYRPHOSTIN A10;Tyrphostin 126;TYRPHOSTIN AG 126;RARECHEM AL BX 0673;AG126, 10 mM in DMSO;AG 126; AG126; AG-126;TYRPHOSTIN AG 126 USP/EP/BP
CBNumber
CB3407273
Molecular Formula
C10H5N3O3
Formula Weight
215.16
MOL File
118409-62-4.mol
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TYRPHOSTIN AG 126 Property

storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
≤0.15mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
form 
Yellow solid
color 
Light yellow to yellow
Sensitive 
Light Sensitive
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
26-36-45
WGK Germany 
3
HazardClass 
6.1
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
658452
Product name
AG 126
Packaging
5mg
Price
$163
Updated
2025/07/31
TCI Chemical
Product number
A3345
Product name
AG-126
Purity
min. 98.0 %
Packaging
5MG
Price
$99
Updated
2025/07/31
TCI Chemical
Product number
A3345
Product name
AG-126
Purity
min. 98.0 %
Packaging
25MG
Price
$298
Updated
2025/07/31
Cayman Chemical
Product number
13297
Product name
AG 126
Purity
≥95%
Packaging
1mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
13297
Product name
AG 126
Purity
≥95%
Packaging
5mg
Price
$84
Updated
2024/03/01
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TYRPHOSTIN AG 126 Chemical Properties,Usage,Production

Uses

AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research[1][2][3][4].

Definition

ChEBI: 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile is a nitrophenol.

Biological Activity

ag-126 is an erk1 and erk2 inhibitor.extracellular signal-regulated kinases (erks) are widely expressed intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions. many different stimuli, such as growth factors, cytokines, transforming agents, and carcinogens, can activate the erk pathway.

in vitro

previous study found that r ag126 ould potently inhibit the pcw-evoked release and this effect was rather selective with respect to the stimulus. ag126 was found to be less potent in attenuating lps-triggered release. moreover, it was found that ag126 was able to prevent the pcw-inducible erk phosphorylation, which could relate to the ag126-mediated inhibition of pcw-evoked cytokine release [1].

in vivo

ag126 was tested in a model of pcw-induced meningitis, in which rats underwent intracisternal injection of pcw with and without ag126 pretreatment. pcw injection led to a dramatic leukocyte influx into the csf. ag126 treatment could significantly attenuate such invasion, without changing the number of circulating leukocytes. in addition, ag126 treatment showed beneficial effects on other parameters, such as intracranial pressure. furthermore, ag126 had no adverse effect on several physiological parameters including mean arterial blood pressure, arterial pao2, paco2 as well as ph [1].

IC 50

inhibits the phosphorylation of erk1 and erk2 at 25-50 μm

References

[1] hanisch, u. k.,prinz, m.,angstwurm, k., et al. the protein tyrosine kinase inhibitor ag126 prevents the massive microglial cytokine induction by pneumococcal cell walls. european journal of immunology 31, 2104-2115 (2001).

TYRPHOSTIN AG 126 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN AG 126 Suppliers

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Spectrum Chemical Manufacturing Corp.
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View Lastest Price from TYRPHOSTIN AG 126 manufacturers

Career Henan Chemical Co
Product
TYRPHOSTIN AG 126 118409-62-4
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-24

118409-62-4, TYRPHOSTIN AG 126Related Search:

AG 99 TYRPHOSTIN AG 835 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) TYRPHOSTIN A63 TYRPHOSTIN A51 TYRPHOSTIN AG 1288 TYRPHOSTIN A9 TYRPHOSTIN A25 AG 18 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Arbutin TYRPHOSTIN A1 1,1-DICYANO-2-(-P-NITROPHENYL)-ETHENE 5-Methyl-2-nitrophenol TYRPHOSTIN AG 126 AG 490 TYRPHOSTIN AG 528

  • RARECHEM AL BX 0673
  • TYRPHOSTIN A10
  • TYRPHOSTIN AG 126
  • ag127
  • AG 126
  • ALPHA-CYANO-(3-HYDROXY-4-NITRO)CINNAMONITRILE
  • [3-HYDROXY-4-NITROBENZYLIDENE]MALONONITRILE
  • Tyrphostin 126
  • AG 126 - CAS 118409-62-4 - Calbiochem
  • AG 126; AG126; AG-126
  • Propanedinitrile, 2-[(3-hydroxy-4-nitrophenyl)methylene]-
  • 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile
  • 2-(3-Hydroxy-4-nitrobenzylidene)malononitrile
  • TYRPHOSTIN AG 126 USP/EP/BP
  • Extracellular signal regulated kinases,BRMECs,Tyrphostin AG 126,ERK,AG-126,Inhibitor,Tyrphostin AG-126,inhibit,AG126,ARPE-19
  • A -126
  • AG-126, Tyrosine kinase inhibitor
  • AG126, 10 mM in DMSO
  • 118409-62-4
  • C10H5N3O3
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Kinase/Phosphatase Biology
  • Receptor Tyrosine Kinase Inhibitors
  • Tyrosine Kinase (TK)
  • API